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Publications Equipe ARChE        

Publications Equipe ARChE

Équipe 3 - ADN Répété, Chromatine, Evolution

Articles dans des revues internationales ou nationales avec comité de lecture


  1. Lancrey A, Joubert A, Boulé JB. Locus specific engineering of tandem DNA repeats in the genome of Saccharomyces cerevisiae using CRISPR/Cas9 and overlapping oligonucleotides. Scientific reports. (2018) 8(1):7127

  1. Nozeret K, Loll F, Mouta Cardoso G, Escudé C, Boutorine AS. Interaction of fluorescently labeled pyrrole-imidazole polyamideprobes with fixed and living murine and human cells. Biochimie. 2017; in revision.
  2. Solé A, Delagoutte E, Ciudad CJ, Noé V, Alberti P. (2017) Polypurine reverse-Hoogsteen(PPRH) oligonucleotides can form triplexes with their targetsequences even under conditions where they fold into G-quadruplexes. Sci Rep. 7:39898.
  3. Cacheux L, Ponger L, Gerbault-Seureau M, Loll F, Gey D, Richard FA, Escudé C. The targeted sequencing of alpha satellite DNA in Cercopithecus pogonias provides new insight into the diversity and dynamics of centromeric repeats in Old World monkeys. Submitted


  1. Cacheux, L. , Ponger, L. , Gerbault-Seureau, M. , Richard, F. A. and Escudé, C. (2016) Diversity and distribution of alpha satellite DNA in thegenome of an Old World monkey: Cercopithecus solatus . BMC Genomics17:916.
  2. Mendoza O, Bourdoncle A, Boulé JB, Brosh RM Jr, Mergny JL. (2016) G-quadruplexes and helicases. Nucleic Acids Res. 44:1989-2006.
  3. Borghi N, Farge E, Lavelle C. (2016) Experimental approaches in mechanotransduction: Frommolecules to pathology. Methods. 94:1-3.
  4. Safa L, Gueddouda NM, Thiébaut F, Delagoutte E, Petruseva I, Lavrik O, Mendoza O, Bourdoncle A, Alberti P, Riou JF, Saintomé C. (2016) 5' to 3' Unfolding Directionality of DNASecondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES. J Biol Chem. 291:21246-21256.
  5. Thouvenot P, Fourrière L, Dardillac E, Ben Yamin B, Lescure A, Lejour V, Heiligenstein X, Boulé JB, Romao M, Raposo-Benedetti G, Lopez BS, Nicolas A, Millot GA. (2016)Yeast cells reveal the misfolding and the cellular mislocalizationof the human BRCA1 protein. J Cell Sci. 129:4366-4378.
  6. Vasilyeva SV, Filichev VV, Boutorine AS. (2016) Application of Cu(I)-catalyzed azide-alkyne cycloaddition forthe design and synthesis of sequence specific probes targetingdouble-stranded DNA. Beilstein J Org Chem. 12:1348-60.
  7. Qiao Q, Le Manach S, Huet H, Duvernois-Berthet E, Chaouch S, Duval C, Sotton B, Ponger L, Marie A, Mathéron L, Lennon S, Bolbach G, Djediat C, Bernard C, Edery M, Marie B. (2016) An integrated omic analysis of hepaticalteration in medaka fish chronically exposed to cyanotoxins withpossible mechanisms of reproductive toxicity. Environ Pollut. 219:119-131.
  8. Qiao Q, Le Manach S, Sotton B, Huet H, Duvernois-Berthet E, Paris A, Duval C, Ponger L, Marie A, Blond A, Mathéron L, Vinh J, Bolbach G, Djediat C, Bernard C, Edery M, Marie B. (2016) Deep sexual dimorphism in adult medakafish liver highlighted by multi-omic approach. Sci Rep. 6:32459.
  9. Cortini R, Barbi M, Caré BR, Lavelle C, Lesne A, Mozziconacci J, Victor J.-M. (2016). The physics of epigenetics. Reviews of Modern Physics 88, 025002.
  10. Lavelle C. (2016). Epigenetics Goes Physical. Biophys. J. 110, 67a.
  11. Lavelle C. (2016). Delicious Biophysics. Biophys. J. 3, 172a-173a.



  1. Gaillard, C, Strauss, F(2015) Construction of DNA hemicatenanes from two small circular DNAmolecules. PLo S One 10:e0119368.
  2. Jiang K, Zhang C, Guttula D, Liu F, van Kan JA, Lavelle C, Kubiak K, Malabirade A, Lapp A, Arluison V, van der Maarel JR. (2015) Effects of Hfq on the conformation and compaction of DNA. Nucleic Acids Res. 43: 4332-4341.
  3. Mendoza O. , Gueddouda N. M. , Boulé J. -B. , Bourdoncle A. , Mergny J. -L. (2015) Afluorescence-based helicase assay: application to the screening of G-quadruplex ligands. Nucleic Acids Res. 43:e71.
  4. Ménoret S, De Cian A, Tesson L, Remy S, Usal C, Boulé JB, Boix C, Fontanière S, Crénéguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I. (2015) Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins. Sci Rep. 5:14410.
  5. Millet A, Strauss F, Delagoutte E(2015) Useof double-stranded DNA mini-circles to characterize the covalent topoisomerase-DNA complex. Sci. Rep. 5:13154.
  6. Nozeret K. , Loll F. , Escudé C. and Boutorine A. S. (2015) Polyamide Fluorescent Probes for Visualization of Repeated DNA Sequences in Living Cells. Chembiochem, 16, 549-554.
  7. Nozeret K, Bonan M, Yarmoluk SM, Novopashina DS, BoutorineAS. (2015) Synthesis of mouse centromere-targeted polyamides andphysico-chemical studies of their interaction with the targetdouble-stranded DNA. Bioorg Med Chem. 23:5932-5945.
  8. Ollion J, Loll F, Cochennec J, Boudier T, Escudé C(2015) Proliferation-dependent positioning of individual centromeres in the interphase nucleus ofjuman lymphoblastoid cell lines. Mol Biol Cell 26-2550-2560.
  9. Ollion J, Cochennec J, Loll F, Escudé C, Boudier T (2015). Analysis of nuclear organization with TANGO, software for high throughput quantitative analysis of 3D fluorescence microscopy images. Methods Mol Biol. 1228:203-222.
  10. Chung L. , Onyango D. , Guo Z, Jia P. , Dai H. , Liu S. , Zhou M. , Lin W. , Pang I. , Li H. , Yuan Y-C. , Huang Q. , Zheng L. , Lopes J. , Nicolas A. , Chai W. , Raz D. , Reckamp K. L. and Shen B. (2015). The FEN1 E359K germline mutation disrupts the FEN1–WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. Oncogene, 34:902-911
  11. Piazza A. , Adrian M. , Samazan F. , Heddi B. , Hamon F. , Serero A. , Lopes J. , Teulade-Fichou M-P. , Phan A. T. and Nicolas A. (2015) Shortloop-length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites. EMBO J. 34, 1718-1734.


  1. Hégarat N, Novopashina D, Fokina AA, BoutorineAS, Venyaminova AG, Praseuth D, François JC. (2014) Monitoring DNAtriplex formation using multicolor fluorescence and application toinsulin-like growth factor I promoter downregulation. FEBS J. 281:1417-1431.
  2. Huet, S. , Lavelle, C. , Ranchon, H. , Carrivain, P. , Victor, J. M. and Bancaud, A. (2014). Relevance and limitations of crowding, fractal, and polymer modelsto describe nuclear architecture: is a unified picture out of reach?Int Rev Cell Mol Biol, 307:443-479.
  3. Lavelle, C. and Foray, N. (2014). Chromatin structure and radiation-induced DNA damage: from structural biology to radiobiology. Int J Biochem Cell Biol, 49:84-97.
  4. Nelissen EC, Dumoulin JC, Busato F, Ponger L, Eijssen LM, Evers JL, Tost J, van Montfoort AP5. (2014) Altered gene expression in human placentas after IVF/ICSI. Hum Reprod. 29:2821-2831.
  5. Novopashina, D. , Fokina, A. A. , Boutorine, A. S. , Venyaminova, A. G. , Praseuth, D. and François J. -C. (2014). Monitoring DNA triplex formation using multicolor fluorescence and application to insulin-like growth factor I promoter down regulation. FEBS J, 281, 1417–1431.
  6. Rakkaa, T. , Escudé, C. , Giet, R. , Magnaghi-Jaulin, L. and Jaulin, C. (2014) CDK11p58 kinase activity is required to protect sister chromatid cohesion atcentromeres in mitosis. Chromosome Research, 22, 267-276.
  7. Safa L, Delagoutte E, Petruseva I, Alberti P, Lavrik O, Riou JF, Saintomé C. (2014)Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability. Biochimie 103:80-88.


  1. Cazaux B. , Catalan J. , Justy F. , Escudé C. , Desmarais E. and Britton-Davidian J. (2013). Evolution of the structure and composition of house mouse satellite DNA sequences in the subgenus Mus (Rodentia: Muridea): a cytogenomic approach. Chromosoma, 122: 209.
  2. Lease R, Arluison V. and Lavelle C. (2013). Twins, quadruplexes and more: functional aspects of native and engineered RNA self-assembly in vivo. Frontiers in Life Sciences, 1: 19.
  3. Ollion J. , Cochennec J. , Loll F. , Escudé C. , and Boudier T. (2013). TANGO: A Generic Tool for High-throughput 3DImage Analysis for Studying Nuclear Organization. Bioinformatics, 29: 1840.
  4. Ruigrok V. J. , Westra E. R. , Brouns S. J. , Escudé C. , Smidt H. and Van der Oost J. (2013). A capture approach forsupercoiled plasmid DNA using a triplex-forming oligonucleotide. Nucleic Acids Research, 41: e111.
  5. Boutorine, A. S. , Novopashina, D. S. , Krasheninina, O. A. , Nozeret, K. and Venyaminova, A. G. (2013). Fluorescent Probes for Nucleic Acid Visualization in Fixed and Live Cells. Molecules, 18, 15357-15397.
  6. Novopashina, D. S. , Sinyakov, A. N. , Ryabinin, V. A. , Boutorine, A. S. , Perrouault, L. , Giovannangeli, C. and Venyaminova, A. G. (2013). Oligo(2'-O-methylribonucleotides) andtheir Derivatives: IV. Conjugates of Oligo(2'-O-methylribonucleotides) with Minor Groove Binders and Intercalators: Synthesis, Properties, and Application. Russ. J. Bioorg. Chem, 39, 138–152.


  1. Barbi, M. , Mozziconacci, J. , Victor, J. M. , Wong, H. and Lavelle, C. (2012). On the Topology of Chromatin Fibers. Interface Focus, 2: 546-54.
  2. Carrivain, P. , Cournac, A. , Lavelle, C. , Lesne, A. , Mozziconacci, J. , Paillusson, F. , Signon, L. , Victor, J. M. and Barbi, M. (2012). Electrostatics of DNA Compaction in Viruses, Bacteria and Eukaryotes: Functional Insights and Evoultionary Perspective. Soft Matter, 36: 9285-301.
  3. De Cian, A. , Praly, E. , Ding, F. , Singh, V. , Lavelle, C. , Le Cam, E. , Croquette, V. , Bensimon, D. and Pietrement, O. (2012). ATP Independent Cooperative Binding of Yeast Isw1a to Bare and Nucleosomal DNA. PLo S One, 7, 2:e31845.
  4. Bancaud, A. , Lavelle, C. , Huet, S. and Ellenberg, J. (2012). A fractal model for nuclearorganization: current evidence and biological implications. Nucleic Acids Res, 40:8783-8792.




Autres publications



  1. Delagoutte E. (2012) DNA polymerases: mechanistic insight from biochemical andbiophysical studies. Front Biosci. 17:509-44.
  2. Lavelle, C. (2014). Pack, unpack, bend, twist, pull, push: the physical side ofgene expression. Curr Opin Genet Dev, 25:74-84.
  3. Boulé JB, Mozziconacci J, Lavelle C. (2015) The polymorphisms of the chromatin fiber. J Phys Condens Matter. 27:033101.


  1. Ollion J, Cochennec J, Loll F, Escudé C, Boudier T (2015) Analysis of nuclear organization with TANGO, software for high throughput quantitative analysis of 3Dfluorescence microscopy images. Methods Mol Biol. 1228:203-222.
  2. Lavelle C, Busi F, Arluison V. (2015) Multiple approaches for the investigationof bacterial small regulatory RNAs self-assembly. Methods Mol Biol. 1297:21-42.
  3. Uriot K and Lavelle C. (2016). Les protéines végétales : un nouvel eldorado nutritionnel. In L'alimentation de demain. Les essentiels Hermès. Pp 181-196.
  4. Lavelle C. (2016). Gastronomie et cuisine moléculaires: entre science et art culinaires. Actes des congrès nationaux des sociétés historiques et scientifiques pp 95-106.
  5. Lavelle C. (2015). Epigénétique et physique. Proceedings from the OPECST public audition on Epigenetics.
  6. Lavelle C. (2015). Products, science and culinary art. Proceedings Geographical Indications Conference, Bhoutan.
  7. Barbot P, Gutrin N, Martin D. and Lavelle C. (2014). De la Science à l'art culinaire. In Science Culinaire (ed Lavelle, C.), Belin pp 297-313.


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