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Publications Equipe GE2R        

Publications Equipe GE2R

Équipe 1 – Genome Editing, DNA double-strand break Repair and cellular Responses (GE2R)

Articles dans des revues internationales ou nationales avec comité de lecture

  1. Mannioui A, Vauzanges Q, Fini JB, Henriet E, Sekizar S, Azoyan L, Thomas JL, Du Pasquier D, Giovannangeli C, 
 Demeneix B, Lubetzki C , Zalc B. The Xenopus tadpole:An in vivo model to screen drugs favoring remyelination. Multiple Sclerosis Journal, 2017 (in press)
  2. Phillips AF, Millet AR, Tigano M, Dubois SM, Crimmins H, Babin L, Charpentier M, Piganeau M, Brunet E, Sfeir A. Single-Molecule Analysis of mt DNA Replication Uncovers the Basis of the Common Deletion. Mol Cell. 2017;65(3):527-538 e526.
  3. Salama A, Mosser M, Leveque X, Perota A, Judor JP, Danna C, Pogu S, Moure A, Jegou D, Gaide N, Abadie J, Gauthier O, Concordet JP, Le Bas-Bernardet S, Riochet D, Le Berre L, Hervouet J, Minault D, Weiss P, Guicheux J, Brouard S, Bosch S, Lagutina I, Duchi R, Lazzari G, Cozzi E, Blancho G, Conchon S, Galli C, Soulillou JP, Bach JM. Neu5Gc and alpha1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs. Diabetes.2017;66(4):987-993.
  4. Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, Jasin M. CRISPR-Cas9-guided oncogenic chromosomal translocationswith conditional fusion protein expression in human mesenchymalcells. Proc Natl Acad Sci U S A. 2017.


  1. Berthelot V, Mouta-Cardoso G, Hegarat N, Guillonneau F, Francois JC, Giovannangeli C, Praseuth D, Rusconi F. The human DNA ends proteome uncovers an unexpected entanglement offunctional pathways. Nucleic Acids Res. 2016;44(10):4721-4733.
  2. Bohm UL, Prendergast A, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C. CSF-contacting neurons regulatelocomotion by relaying mechanical stimuli to spinal circuits. Nat Commun. 2016;7:10866.
  3. Di Donato V, De Santis F, Auer TO, Testa N, Sanchez-Iranzo H, Mercader N, Concordet JP, Del Bene F. 2C-Cas9: a versatile tool for clonal analysis of genefunction. Genome Res. 2016;26(5):681-692.
  4. Eckenfelder A, Segeral E, Pinzon N, Ulveling D, Amadori C, Charpentier M, Nidelet S, Concordet JP, Zagury JF, Paillart JC, Berlioz-Torrent C, Seitz H, Emiliani S, Gallois-Montbrun S. Argonaute proteins regulate HIV-1 multiplyspliced RNA and viral production in a Dicer independent manner. Nucleic Acids Res. 2016.
  5. Gammage PA, Gaude E, Van Haute L, Rebelo-Guiomar P, Jackson CB, Rorbach J, Pekalski ML, Robinson AJ, Charpentier M, Concordet JP, Frezza C, Minczuk M. Near-complete elimination of mutant mt DNA byiterative or dynamic dose-controlled treatment with mt ZFNs. Nucleic Acids Res. 2016;44(16):7804-7816.
  6. Haeussler M, Schonig K, Eckert H, Eschstruth A, Mianne J, Renaud JB, Schneider-Maunoury S, Shkumatava A, Teboul L, Kent J, Joly JS, Concordet JP. Evaluation of off-target and on-target scoring algorithms andintegration into the guide RNA selection tool CRISPOR. Genome Biol. 2016;17(1):148.
  7. Koutroumpa FA, Monsempes C, Francois MC, de Cian A, Royer C, Concordet JP, Jacquin-Joly E. Heritable genome editing with CRISPR/Cas9 inducesanosmia in a crop pest moth. Sci Rep. 2016;6:29620.
  8. Kovar H, Amatruda J, Brunet E, Burdach S, Cidre-Aranaz F, de Alava E, Dirksen U, van der Ent W, Grohar P, Grunewald TG, Helman L, Houghton P, Iljin K, Korsching E, Ladanyi M, Lawlor E, Lessnick S, Ludwig J, Meltzer P, Metzler M, Mora J, Moriggl R, Nakamura T, Papamarkou T, Radic Sarikas B, Redini F, Richter GH, Rossig C, Schadler K, Schafer BW, Scotlandi K, Sheffield NC, Shelat A, Snaar-Jagalska E, Sorensen P, Stegmaier K, Stewart E, Sweet-Cordero A, Szuhai K, Tirado OM, Tirode F, Toretsky J, Tsafou K, Uren A, Zinovyev A, Delattre O. The second Europeaninterdisciplinary Ewing sarcoma research summit--A joint effort todeconstructing the multiple layers of a complex disease. Oncotarget. 2016;7(8):8613-8624.
  9. Perota A, Lagutina I, Quadalti C, Duchi R, Turini P, Crotti G, Colleoni S, Conchon S, Concordet JP, Lazzari G, Soulillou JP, Galli C. 203 Single-Step Gene Editing of 3Xenoantigens in Porcine Fibroblasts Using Programmable Nucleases. Reprod Fertil Dev. 2016;29(1):210-211.
  10. Piganeau M, Renouf B, Ghezraoui H, Brunet E. TALEN-Induced Translocations in Human Cells. Methods Mol Biol. 2016;1338:99-117.
  11. Renaud JB, Boix C, Charpentier M, De Cian A, Cochennec J, Duvernois-Berthet E, Perrouault L, Tesson L, Edouard J, Thinard R, Cherifi Y, Menoret S, Fontaniere S, de Croze N, Fraichard A, Sohm F, Anegon I, Concordet JP, Giovannangeli C. Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases. Cell Rep. 2016;14(9):2263-2272.
  12. Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P. Myo D reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis. Nucleic Acids Res. 2016;44(18):8621-8640.
  13. Steed E, Faggianelli N, Roth S, Ramspacher C, Concordet JP, Vermot J. klf2a couples mechanotransduction and zebrafish valvemorphogenesis through fibronectin synthesis. Nat Commun. 2016;7:11646.
  14. Tesson L, Remy S, Menoret S, Usal C, Thinard R, Savignard C, De Cian A, Giovannangeli C, Concordet JP, Anegon I. Genome Editing in Rats Using TALE Nucleases. Methods Mol Biol. 2016;1338:245-259.


  1. Blasimme A, Anegon I, Concordet JP, De Vos J, Dubart-Kupperschmitt A, Fellous M, Fouchet P, Frydman N, Giovannangeli C, Jouannet P, Serre JL, Steffann J, Rial-Sebbag E, Thomsen M, Cambon-Thomsen A. Genome Editing and Dialogic Responsibility:"What's in a Name?". Am J Bioeth. 2015;15(12):54-57.
  2. Menoret S, De Cian A, Tesson L, Remy S, Usal C, Boule JB, Boix C, Fontaniere S, Creneguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I. Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins. Sci Rep. 2015;5:14410.
  3. Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez-Morales JR, Wittbrodt J. Sox2, Tlx, Gli3, and Her9 convergeon Rx2 to define retinal stem cells in vivo. EMBO J. 2015;34(11):1572-1588.
  4. Auer TO, Xiao T, Bercier V, Gebhardt C, Duroure K, Concordet JP, Wyart C, Suster M, Kawakami K, Wittbrodt J, Baier H, Del Bene F. Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. Elife. 2015;4.


  1. Auer TO, Duroure K, Concordet JP, Del Bene F. CRISPR/Cas9-mediated conversion of e GFP- into Gal4-transgenic lines in zebrafish. Nat Protoc. 2014;9(12):2823-2840.
  2. Auer TO, Duroure K, De Cian A, Concordet JP, Del Bene F. Highly efficient CRISPR/Cas9-mediated knock-in inzebrafish by homology-independent DNA repair. Genome Res. 2014;24(1):142-153.
  3. Ghezraoui H, Piganeau M, Renouf B, Renaud JB, Sallmyr A, Ruis B, Oh S, Tomkinson AE, Hendrickson EA, Giovannangeli C, Jasin M, Brunet E. Chromosomal translocations in human cells are generated by canonicalnonhomologous end-joining. Mol Cell. 2014;55(6):829-842.
  4. Cordier C, Boutimah F, Bourdeloux M, Dupuy F, Met E, Alberti P, Loll F, Chassaing G, Burlina F, Saison-Behmoaras TE. Delivery of antisense peptide nucleic acids to cells by conjugationwith small arginine-rich cell-penetrating peptide (R/W)9. PLo S One. 2014;9(8):e104999.
  5. Hegarat N, Novopashina D, Fokina AA, Boutorine AS, Venyaminova AG, Praseuth D, Francois JC. Monitoring DNA triplex formation using multicolor fluorescence and applicationto insulin-like growth factor I promoter downregulation. FEBS J. 2014;281(5):1417-1431.
  6. Moison C, Assemat F, Daunay A, Tost J, Guieysse-Peugeot AL, Arimondo PB. Synergistic chromatin repression of the tumorsuppressor gene RARB in human prostate cancers. Epigenetics. 2014;9(4):477-482.
  7. Larcher T, Lafoux A, Tesson L, Remy S, Thepenier V, Francois V, Le Guiner C, Goubin H, Dutilleul M, Guigand L, Toumaniantz G, De Cian A, Boix C, Renaud JB, Cherel Y, Giovannangeli C, Concordet JP, Anegon I, Huchet C. Characterization of dystrophin deficient rats: a newmodel for Duchenne muscular dystrophy. PLo S One. 2014;9(10):e110371.
  8. Menoret S, Tesson L, Remy S, Usal C, Thepenier V, Thinard R, Ouisse LH, De Cian A, Giovannangeli C, Concordet JP, Anegon I. Gene targeting in rats using transcription activator-likeeffector nucleases. Methods. 2014;69(1):102-107.
  9. Remy S, Tesson L, Menoret S, Usal C, De Cian A, Thepenier V, Thinard R, Baron D, Charpentier M, Renaud JB, Buelow R, Cost GJ, Giovannangeli C, Fraichard A, Concordet JP, Anegon I. Efficient gene targeting by homology-directed repair inrat zygotes using TALE nucleases. Genome Res. 2014;24(8):1371-1383.
  10. Renouf B, Piganeau M, Ghezraoui H, Jasin M, Brunet E. Creating cancer translocations in human cells using Cas9 DSBs andn Cas9 paired nicks. Methods Enzymol. 2014;546:251-271.


  1. Moison C, Senamaud-Beaufort C, Fourriere L, Champion C, Ceccaldi A, Lacomme S, Daunay A, Tost J, Arimondo PB, Guieysse-Peugeot AL. DNA methylation associated with polycomb repression in retinoic acidreceptor beta silencing. FASEB J. 2013;27(4):1468-1478.
  2. Novopashina DS, Siniakov AN, Riabinin VA, Perrouault L, Giovannangeli C, Venyaminova AG, Boutorin AS. Oligo(2'-O-Methylribonucleotides) and their derivatives: IV. Conjugates of oligo (2'-O-methylribonucleotides) with minor groovebinders and intercalators: synthesis, properties and application. Bioorg Khim. 2013;39(2):159-174.
  3. Piganeau M, Ghezraoui H, De Cian A, Guittat L, Tomishima M, Perrouault L, Rene O, Katibah GE, Zhang L, Holmes MC, Doyon Y, Concordet JP, Giovannangeli C, Jasin M, Brunet E. Cancer translocations in human cells induced by zinc finger and TALEnucleases. Genome Res. 2013;23(7):1182-1193.


  1. Durfort, T., Tkach, M., Meschaninova, M. I., Rivas, M. A., Elizalde, P. V., Venyaminova, A. G., Schillaci, R. & François, J. C. (2012). Small Interfering RNA Targeted to IGF-IR Delays Tumor Growth and Induces Proinflammatory Cytokines in a Mouse Breast Cancer Model. PLoS One, 7, 1: e29213. (IF: 4,54)
  2. Fokina, A. A., Meschaninova, M. I., Durfort, T., Venyaminova, A. G. & François, J. C. (2012). Targeting Insulin-Like Growth Factor I with 10-23 DNAzymes: 2'-O-Methyl Modifications in the Catalytic Core Enhance mRNA Cleavage. Biochemistry, 51, 11: 2181-91. (IF: 3,25)
  3. Halby, L., Champion, C., Senamaud-Beaufort, C., Ajjan, S., Drujon, T., Rajavelu, A., Ceccaldi, A., Jurkowska, R., Lequin, O., Nelson, W. G., Guy, A., Jeltsch, A., Guianvarc'h, D., Ferroud, C. & Arimondo, P. B. (2012). Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide. ChemBioChem, 13, 1: 157-65. (IF: 3,72)
  4. Marlin, F., Simon, P., Bonneau, S, Alberti, P, Cordier, C, Boix, C, Perrouault, L, Fossey, A, Saison-Behmoaras, T., Fontecave, M & Giovannangeli, C. (2012). Flavin conjugates for delivery of peptide nucleic acids. ChemBioChem, DOI: 10.1002/cbic.201200505. (IF: 3,72)
  5. Massoni-Laporte, A., Perrot, M., Ponger, L., Boucherie, H. & Guieysse-Peugeot, A. L. (2012). Proteome Analysis of a CTR9 Deficient Yeast Strain Suggests That Ctr9 Has Function(s) Independent of the Paf1 Complex. Biochim Biophys Acta - - Proteins and Proteomics, 1824, 5: 759-68. (IF: 3,64)
  6. Vekhoff, P., Duca, M., Guianvarc'h, D., Benhida, R. & Arimondo, P. B. (2012). Sequence-Specific Base Pair Mimics Are Efficient Topoisomerase Ib Inhibitors. Biochemistry, 51, 1: 43-51. (IF: 3,25)
  7. Bensasson, R. V., Zoete, V., Jossang, A., Bodo, B., Arimondo, P. B. & Land, E. J. (2011). Potency of Inhibition of Human DNA Topoisomerase I by Flavones Assessed through Physicochemical Parameters. Free Radic Biol Med, 51, 7: 1406-10. (IF: 5,77)
  8. Ceccaldi, A., Rajavelu, A., Champion, C., Rampon, C., Jurkowska, R., Jankevicius, G., Senamaud-Beaufort, C., Ponger, L., Gagey, N., Ali, H. D., Tost, J., Vriz, S., Ros, S., Dauzonne, D., Jeltsch, A., Guianvarc'h, D. & Arimondo, P. B. (2011). C5-DNA Methyltransferase Inhibitors: From Screening to Effects on Zebrafish Embryo Development. ChemBioChem, 12, 9: 1337-45. (IF: 3,72)
  9. Concordet, J. P. & Giovannangeli, C. (2011). Engineered Nucleases for Targeted Genome Modification. Curr Gene Ther, 11, 1: 1. (IF: 4,09)
  10. Doluca, O., Boutorine, A. S. & Filichev, V. V. (2011). Triplex-Forming Twisted Intercalating Nucleic Acids (TINAas): Design Rules, Stabilization of Antiparallel DNA Triplexes and Inhibition of G-Quartet-Dependent Self-Association. ChemBioChem, 12, 15: 2365-74. (IF: 3,72)
  11. Jurkowska, R. Z., Ceccaldi, A., Zhang, Y., Arimondo, P. B. & Jeltsch, A. (2011). DNA Methyltransferase Assays. Methods Mol Biol, 791: 157-77. (IF: 13,9)
  12. Kanhoush, R., Praseuth, D., Perrin, C., Chardard, D., Vinh, J. & Penrad-Mobayed, M. (2011). Differential RNA-Binding Activity of the hnRNP G Protein Correlated with the Sex Genotype in the Amphibian Oocyte. Nucleic Acids Res, 39, 10: 4109-21. (IF: 7,42)
  13. Le Breton, C., Hennion, M., Arimondo, P. B. & Hyrien, O. (2011). Replication-Fork Stalling and Processing at a Single Psoralen Interstrand Crosslink in Xenopus Egg Extracts. PLoS One, 6, 4: e18554. (IF: 4,54)
  14. Lecosnier, S., Cordier, C., Simon, P., François, J. C. & Saison-Behmoaras, T. E. (2011). A Steric Blocker of Translation Elongation Inhibits IGF-IR Expression and Cell Transformation. Faseb J, 25, 7: 2201-10. (IF: 6,34)
  15. Mazzoccoli, G., Tarquini, R., Durfort, T. & François, J. C. (2011). Chronodisruption in Lung Cancer and Possible Therapeutic Approaches. Biomed Pharmacother, 65, 7: 500-8. (IF: 2,34)
  16. Moison, C., Arimondo, P. B. & Guieysse-Peugeot, A. L. (2011). Commercial Reverse Transcriptase as Source of False-Positive Strand-Specific RNA Detection in Human Cells. Biochimie, 93, 10: 1731-7. (IF: 3,42)
  17. Nakanishi, K., Cavallo, F., Perrouault, L., Giovannangeli, C., Moynahan, M. E., Barchi, M., Brunet, E. & Jasin, M. (2011). Homology-Directed Fanconi Anemia Pathway Cross-Link Repair Is Dependent on DNA Replication. Nat Struct Mol Biol, 18, 4: 500-3. (IF: 12,11)
  18. Pitts, S. L., Jablonksy, M. J., Duca, M., Dauzonne, D., Monneret, C., Arimondo, P. B., Anklin, C., Graves, D. E. & Osheroff, N. (2011). Contributions of the D-Ring to the Activity of Etoposide against Human Topoisomerase II alpha: Potential Interactions with DNA in the Ternary Enzyme-Drug-DNA Complex. Biochemistry, 50, 22: 5058-66. (IF: 3,25)
  19. Riva, C., Binelli, A., Rusconi, F., Colombo, G., Pedriali, A., Zippel, R. & Provini, A. (2011). A Proteomic Study Using Zebra Mussels (D. Polymorpha) Exposed to Benzo(Alpha)Pyrene: The Role of Gender and Exposure Concentrations. Aquat Toxicol, 104, 39478: 14-22. (IF: 4,23)
  20. Simsek# , D., Brunet# , E., Wong, S. Y., Katyal, S., Gao, Y., McKinnon, P. J., Lou, J., Zhang, L., Li, J., Rebar, E. J., Gregory, P. D., Holmes, M. C. & Jasin, M. (2011). DNA Ligase III Promotes Alternative Nonhomologous End-Joining During Chromosomal Translocation Formation. PLoS Genet, 7, 6: e1002080. (IF: 9,17)
  21. Alvarez, L., Levin, C. H., Merola, F., Bizouarn, T., Pasquier, H., Baciou, L., Rusconi, F. & Erard, M. (2010). Are the Fluorescent Properties of the Cyan Fluorescent Protein Sensitive to Conditions of Oxidative Stress? Photochem Photobiol, 86, 1: 55-61. (IF: 2,64)
  22. Ayel, E. & Escude, C. (2010). In Vitro Selection of Oligonucleotides That Bind Double-Stranded DNA in the Presence of Triplex-Stabilizing Agents. Nucleic Acids Res, 38, 5: e31. (IF: 7,42)
  23. Braslau, A., van Noort, J. & Arimondo, P. B. (2010). "Introduction "DNA and Chromosomes: Physical and Biological Approaches". Biochimie, 92, 12: v-vi. (IF: 3,42)
  24. Champion, C., Guianvarc'h, D., Senamaud-Beaufort, C., Jurkowska, R. Z., Jeltsch, A., Ponger, L., Arimondo, P. B. & Guieysse-Peugeot, A. L. (2010). Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine. PLoS One, 5, 8: e12388. (IF: 4,54)
  25. Marlin, F., Simon, P., Saison-Behmoaras, T. & Giovannangeli, C. (2010). Delivery of Oligonucleotides and Analogues: The Oligonucleotide Conjugate-Based Approach. ChemBioChem, 11, 11: 1493-500. (IF: 3,72)
  26. Miroglio, A., Jammes, H., Tost, J., Ponger, L., Gut, I. G., El Abdalaoui, H., Coste, J., Chaussade, S., Arimondo, P. B., Lamarque, D. & Dandolo, L. (2010). Specific Hypomethylated CpGs at the IGF2 Locus Act as an Epigenetic Biomarker for Familial Adenomatous Polyposis Colorectal Cancer. Epigenomics, 2, 3: 365-75. (IF: 2,38)
  27. Oussedik, K., François, J. C., Halby, L., Senamaud-Beaufort, C., Toutirais, G., Dallavalle, S., Pommier, Y., Pisano, C. & Arimondo, P. B. (2010). Sequence-Specific Targeting of IGF-I and IGF-IR Genes by Camptothecins. Faseb J, 24, 7: 2235-44. (IF: 6,34)
  28. Trojan, J., Ly, A., Wei, M. X., Bierwagen, M., Kopinski, P., Pan, Y., Ardourel, M. Y., Dufour, T., Shevelev, A., Trojan, L. A., François, J. C., Andres, C., Popiela, T., Chatel, M., Kasprzak, H., Anthony, D. D. & Duc, H. T. (2010). Antisense Anti IGF-I Cellular Therapy of Malignant Tumours: Immune Response in Cancer Patients. Biomed Pharmacother, 64, 8: 576-8. (IF: 2,34)
  29. Alvarez, L. A., Merola, F., Erard, M. & Rusconi, F. (2009). Mass Spectrometry-Based Structural Dissection of Fluorescent Proteins. Biochemistry, 48, 18: 3810-2. (IF: 3,25)
  30. Biebricher, A., Wende, W., Escude, C., Pingoud, A. & Desbiolles, P. (2009). Tracking of Single Quantum Dot Labeled EcoRV Sliding Along DNA Manipulated by Double Optical Tweezers. Biophys J, 96, 8: L50-2. (IF: 4,14)
  31. Boutorine, A. S., Doluca, O. & Filichev, V. V. (2009). Optimization of the Sequence of Twisted Intercalating Nucleic Acids (TINA) Forming Triple Helix with the Polypurine Tract of the Proviral HIV DNA. Nucleic Acids Symp Ser (Oxf), 53: 139-40.
  32. Buchmann, W., Boutorine, A., Halby, L., Tortajada, J. & De Pauw, E. (2009). A New Method for the Determination of the Relative Affinity of a Ligand against Various DNA Sequences by Electrospray Ionization Mass Spectrometry. Application to a Polyamide Minor Groove Binder. J Mass Spectrom, 44, 8: 1171-81. (IF: 3,3)
  33. Escude, C., Geron-Landre, B., Crut, A. & Desbiolles, P. (2009). Multicolor Detection of Combed DNA Molecules Using Quantum Dots. Methods Mol Biol, 544: 357-66. (IF: 13,9)
  34. Lyonnais, S., Chung, C. L., Goux-Capes, L., Escude, C., Pietrement, O., Baconnais, S., Le Cam, E., Bourgoin, J. P. & Filoramo, A. (2009). A Three-Branched DNA Template for Carbon Nanotube Self-Assembly into Nanodevice Configuration. Chem Commun (Camb), 6: 683-5. (IF: 6,08)
  35. Malecot, M., Mezhoud, K., Marie, A., Praseuth, D., Puiseux-Dao, S. & Edery, M. (2009). Proteomic Study of the Effects of Microcystin-LR on Organelle and Membrane Proteins in Medaka Fish Liver. Aquat Toxicol, 94, 2: 153-61. (IF: 4,23)
  36. Quanz, M., Chassoux, D., Berthault, N., Agrario, C., Sun, J. S. & Dutreix, M. (2009). Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response. PLoS One, 4, 7: e6298. (IF: 4,54)
  37. Rusconi, F. (2009). Massxpert 2: A Cross-Platform Software Environment for Polymer Chemistry Modelling and Simulation; Analysis of Mass Spectrometric Data. Bioinformatics, 25, 20: 2741-2. (IF: 6,05)
  38. Vekhoff, P., Halby, L., Oussedik, K., Dallavalle, S., Merlini, L., Mahieu, C., Lansiaux, A., Bailly, C., Boutorine, A., Pisano, C., Giannini, G., Alloatti, D. & Arimondo, P. B. (2009). Optimized Synthesis and Enhanced Efficacy of Novel Triplex-Forming Camptothecin Derivatives Based on Gimatecan. Bioconjug Chem, 20, 4: 666-72. (IF: 5,22)
  39. Bonnet, I., Biebricher, A., Porte, P. L., Loverdo, C., Benichou, O., Voituriez, R., Escude, C., Wende, W., Pingoud, A. & Desbiolles, P. (2008). Sliding and Jumping of Single EcoRV Restriction Enzymes on Non-Cognate DNA. Nucleic Acids Res, 36, 12: 4118-27. (IF: 7,42)
  40. Boutorine, A. S., Buchmann, W., Halby, L. & De Pauw, E. (2008). Studies of Sequence-Specific Recognition and Interaction of Bis-Hairpin Polyamide Minor Groove Binders with Target DNA Duplexes. Nucleic Acids Symp Ser (Oxf), 52: 105-6.
  41. Coolen, M., Menuet, A., Chassoux, D., Compagnucci, C., Henry, S., Leveque, L., Da Silva, C., Gavory, F., Samain, S., Wincker, P., Thermes, C., D'Aubenton-Carafa, Y., Rodriguez-Moldes, I., Naylor, G., Depew, M., Sourdaine, P. & Mazan, S. (2008). The Dogfish Scyliorhinus Canicula: A Reference in Jawed Vertebrates. CSH Protoc, 2008: doi:10.1101/pdb.emo111.
  42. Duca, M., Vekhoff, P., Oussedik, K., Halby, L. & Arimondo, P. B. (2008). The Triple Helix: 50 Years Later, the Outcome. Nucleic Acids Res, 36, 16: 5123-38. (IF: 7,42)
  43. Fokina, A., Novopashina, D., Meschaninova, M., François, J.C. & Venyaminova, A. (2008). 3'-Modified Oligo(2'-O-Methylribonucleotides) Improve Cleavage of Long Structured RNA by DNAzyme 10-23. Chemistry of Nucleic Acid Components., 10: 420-2.
  44. Fokina, A., Novopashina, D., Meschaninova, M., Vorobjeva, M., Zenkova, M., Francois, J.C & Venyaminova, A. (2008). Effective Cleavage of Structured RNAs by Tandems of 10-23 DNAzymes with 3'-Modified Oligo(2'-O-Methylribonucleotide)-Effectors. Nucleic Acids Symp Ser (Oxf). 52: 525-6.
  45. Giovannangeli, C. & Saison-Behmoras, T. (2008). Therapeutic Oligonucleotides. ChemBioChem, 9, 18: 3087-8. (IF: 3,72)
  46. Hegarat, N., François, J. C. & Praseuth, D. (2008). Modern Tools for Identification of Nucleic Acid-Binding Proteins. Biochimie, 90, 9: 1265-72. (IF: 3,42)
  47. Kamashev, D., Balandina, A., Mazur, A. K., Arimondo, P. B. & Rouvière-Yaniv, J. (2008). HU Binds and Folds Single-Stranded DNA. Nucleic Acids Res, 36, 3: 1026-36. (IF: 7,42)
  48. Koster, D. A., Czerwinski, F., Halby, L., Crut, A., Vekhoff, P., Palle, K., Arimondo, P. B. & Dekker, N. H. (2008). Single-Molecule Observations of Topotecan-Mediated TopIB Activity at a Unique DNA Sequence. Nucleic Acids Res, 36, 7: 2301-10. (IF: 7,42)
  49. Lyonnais, S., Goux-Capes, L., Escude, C., Cote, D., Filoramo, A. & Bourgoin, J. P. (2008). DNA-Carbon Nanotube Conjugates Prepared by a Versatile Method Using Streptavidin-Biotin Recognition. Small, 4, 4: 442-6. (IF: 8,26)
  50. Mezhoud, K., Bauchet, A. L., Chateau-Joubert, S., Praseuth, D., Marie, A., François, J. C., Fontaine, J. J., Jaeg, J. P., Cravedi, J. P., Puiseux-Dao, S. & Edery, M. (2008). Proteomic and Phosphoproteomic Analysis of Cellular Responses in Medaka Fish (Oryzias Latipes) Following Oral Gavage with Microcystin-LR. Toxicon, 51, 8: 1431-9. (IF: 2,48)
  51. Mezhoud, K., Praseuth, D., François, J. C., Bernard, C. & Edery, M. (2008). Global Quantitative Analysis of Protein Phosphorylation Status in Fish Exposed to Microcystin. Adv Exp Med Biol, 617: 419-26. (IF: 1,37)
  52. Mezhoud, K., Praseuth, D., Puiseux-Dao, S., François, J. C., Bernard, C. & Edery, M. (2008). Global Quantitative Analysis of Protein Expression and Phosphorylation Status in the Liver of the Medaka Fish (Oryzias Latipes) Exposed to Microcystin-LR I. Balneation Study. Aquat Toxicol, 86, 2: 166-75. (IF: 4,23)
  53. Oussedik, K., Durfort, T., Halby, L., Senamaud-Beaufort, C., François, J. & Arimondo, P. (2008). Specific Targeting of IGF-I and IGF-IR Genes by Antigene Nucleic Acids. Growth Hormone & IGF Research, 18: S28. (IF: 2,13)
  54. Simon, P., Cannata, F., Concordet, J. P. & Giovannangeli, C. (2008). Targeting DNA with Triplex-Forming Oligonucleotides to Modify Gene Sequence. Biochimie, 90, 8: 1109-16. (IF: 3,42)
  55. Simon, P., Cnnata, F., Perrouault, L., Halby, L., Concordet, J. P., Boutorine, A., Ryabinin, V., Sinyakov, A. & Giovannangeli, C. (2008). Sequence-Specific DNA Cleavage Mediated by Bipyridine Polyamide Conjugates. Nucleic Acids Res, 36, 11: 3531-8. (IF: 7,42)
  56. Stierle, V., Duca, M., Halby, L., Senamaud-Beaufort, C., Capobianco, M. L., Laigle, A., Jolles, B. & Arimondo, P. B. (2008). Targeting MDR1 Gene: Synthesis and Cellular Study of Modified Daunomycin-Triplex-Forming Oligonucleotide Conjugates Able to Inhibit Gene Expression in Resistant Cell Lines. Mol Pharmacol, 73, 5: 1568-77. (IF: 4,58)
  57. Vekhoff, P., Ceccaldi, A., Polverari, D., Pylouster, J., Pisano, C. & Arimondo, P. B. (2008). Triplex Formation on DNA Targets: How to Choose the Oligonucleotide. Biochemistry, 47, 47: 12277-89. (IF: 3,25)
  58. Walser, J. C., Ponger, L. & Furano, A. V. (2008). CpG Dinucleotides and the Mutation Rate of Non-CpG DNA. Genome Res, 18, 9: 1403-14. (IF: 12,49)
  59. Absalon, S., Kohl, L., Branche, C., Blisnick, T., Toutirais, G., Rusconi, F., Cosson, J., Bonhivers, M., Robinson, D. & Bastin, P. (2007). Basal Body Positioning Is Controlled by Flagellum Formation in Trypanosoma Brucei. PLoS One, 2, 5: e437. (IF: 4,54)
  60. Blouquit, Y., Duchambon, P., Brun, E., Marco, S., Rusconi, F. & Sicard-Roselli, C. (2007). High Sensitivity of Human Centrin 2 toward Radiolytical Oxidation: C-Terminal Tyrosinyl Residue as the Main Target. Free Radic Biol Med, 43, 2: 216-28. (IF: 5,77)
  61. Boutimah-Hamoudi, F., Leforestier, E., Senamaud-Beaufort, C., Nielsen, P. E., Giovannangeli, C. & Saison-Behmoaras, T. E. (2007). Cellular Antisense Activity of Peptide Nucleic Acid (PNAs) Targeted to HIV-1 Polypurine Tract (PPT) Containing RNA. Nucleic Acids Res, 35, 12: 3907-17. (IF: 7,42)
  62. Boutorine, A. S., Halby, L., Simon, P., Perrouault, L., Giovannangeli, C., Gursky, G. V., Surovaya, A. N., Grokhovsky, S. L., Ryabinin, V. A. & Sinyakov, A. N. (2007). Sequence-Specific Recognition of Double-Stranded DNA by Synthetic Minor Groove Binder Conjugates. Toward the Construction of Artificial Site-Specific Deoxyribonucleases. Nucleosides Nucleotides Nucleic Acids, 26, 10-12: 1559-63. (IF: 0,78)
  63. Escude, C., Roulon, T., Lyonnais, S. & Le Cam, E. (2007). Multiple Topological Labeling for Imaging Single Plasmids. Anal Biochem, 362, 1: 55-62. (IF: 3,25)
  64. Halby, L., Ryabinin, V. A., Sinyakov, A. N., Novopashina, D. S., Venyaminova, A. G., Grokhovsky, S. L., Surovaya, A. N., Gursky, G. V. & Boutorine, A. S. (2007). Head-to-Head Bis-Hairpin Polyamide Minor Groove Binders and Their Conjugates with Triplex-Forming Oligonucleotides: Studies of Interaction with Target Double-Stranded DNA. J Biomol Struct Dyn, 25, 1: 61-76. (IF: 4,99)
  65. Hassani, Z., François, J. C., Alfama, G., Dubois, G. M., Paris, M., Giovannangeli, C. & Demeneix, B. A. (2007). A Hybrid CMV-H1 Construct Improves Efficiency of PEI-Delivered shRNA in the Mouse Brain. Nucleic Acids Res, 35, 9: e65. (IF: 7,42)
  66. Hegarat, N., Cardoso, G. M., Rusconi, F., François, J. C. & Praseuth, D. (2007). Analytical Biochemistry of DNA-Protein Assemblies from Crude Cell Extracts. Nucleic Acids Res, 35, 13: e92. (IF: 7,42)
  67. Losytskyy, M. Y., Akbay, N., Kovalska, V. B., Balanda, A. O., Boutorine, A. S. & Yarmoluk, S. M. (2007). To the Studies of (p-Dimethylaminostyryl) Pyridinium Based Homodimer to dsDNA Binding Mechanism. Ukrainica Bioorganica Acta, 5, 2: 52-55. (IF: ND)
  68. Mainardi, J. L., Hugonnet, J. E., Rusconi, F., Fourgeaud, M., Dubost, L., Moumi, A. N., Delfosse, V., Mayer, C., Gutmann, L., Rice, L. B. & Arthur, M. (2007). Unexpected Inhibition of Peptidoglycan LD-Transpeptidase from Enterococcus Faecium by the Beta-Lactam Imipenem. J Biol Chem, 282, 42: 30414-22. (IF: 5,12)
  69. Mozziconacci, O., Mirkowski, J., Rusconi, F., Pernot, P., Bobrowski, K. & Houee-Levin, C. (2007). Superoxide Radical Anions Protect Enkephalin from Oxidation If the Amine Group Is Blocked. Free Radic Biol Med, 43, 2: 229-40. (IF: 5,77)
  70. Nollmann, M., Crisona, N. J. & Arimondo, P. B. (2007). Thirty Years of Escherichia Coli DNA Gyrase: From in Vivo Function to Single-Molecule Mechanism. Biochimie, 89, 4: 490-9. (IF: 3,42)
  71. Perrot, M., Guieysse-Peugeot, A. L., Massoni, A., Espagne, C., Claverol, S., Silva, R. M., Jeno, P., Santos, M., Bonneu, M. & Boucherie, H. (2007). Yeast Proteome Map (Update 2006). Proteomics, 7, 7: 1117-20. (IF: 4,43)
  72. Rossignol, J. M., Jacquet, M. & Arimondo, P. B. (2007). DNA, More Than Just a Ladder. A Tribute to Michel Duguet (1943-2005). Biochimie, 89, 4: 423-6. (IF: 3,42)



Autres publications

  1. Concordet JP. , Giovannangeli C. CRISPR/Cas systems for genome engineering and investigation. Methods. 2017;121-122.
  2. Duroux-Richard I, Giovannangeli C, Apparailly F. CRISPR-Cas9: A revolution in genome editing inrheumatic diseases. Joint Bone Spine. 2017;84(1):1-4.
  3. Haeussler M, Concordet JP. Genome Editing with CRISPR-Cas9: Can It Get Any Better? J Genet Genomics. 2016;43(5):239-250.
  4. Momose T, Concordet JP. Diving into marine genomics with CRISPR/Cas9 systems. Mar Genomics. 2016;30:55-65.
  5. Giovannangeli C, Concordet JP. Editing and investigating genomes with TALE and CRISPR/Cas systems:applications of artificial TALE and CRISPR-Cas systems. Methods. 2014;69(2):119-120.


  1. François, J. C., Giovannangeli, C. (2014). Antisense and Antigene Strategies Using Synthetic Oligonucleotides. In Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology
  2. Boutorine, A. S., Escudé, C. (2007). Biophysical Analysis of Triple-Helix Formation. In Curr Protoc Nucleic Acid Chem. pp. Unit 7 12.
  3. Rusconi, F. (2011). Manuel De Spectrométrie De Masse à L'Usage Des Biochimistes. Collection Tec & Doc.
  4. Kluza, J. A., Arimondo, P.B., David-Cordonnier, M.H., Bailly, C. (2007). Camptothecins for Drug Design, Cancer Cell Death, and Gene Targeting. In Cancer Drug Design and Discovery. (ed. S. Neidle). Elsevier Science & Technology Books.

  1. Rusconi, F. (2010). Cross-Platform Mass Spectrometry. G.I.T Laboratory Journal Europe, 14: 20-21.
  2. Rusconi, F. (2010). Massxpert V2 : Un Environnement Logiciel Multi-Plateforme pour la Modélisation de Chimies de Polymère et l'Analyse: Simulation de Données de Spectrométrie de Masse. Spectra Analyse, 273: 40-44.
  3. Giovannangeli, C. (2009). Cibler L’ADN, Pour la Compréhension du Vivant. L'Actualité Chimique: 41-57.
  4. Arimondo, P. B. & Guianvarc'h, D. (2007). Quand l’ADN Donne du Fil à Retordre aux Topoisomérases : Une Liaison Pour le Meilleur et Pour le Pire Exploitée Dans la Conception de Médicaments. L'Actualité Chimique, 311: 21-26.
  5. Herpin, T. & Escudé, C. (2008). La Course à la Prochaine Génération de Biothérapeutiques. La jaune et la rouge (revue des anciens élèves de l'Ecole Polytechnique), 642: 18-21.
  6. Terrier, P., Boutorine, A., Halby, L., De Pauw, E., Tortajada, J. & Buchmann, W. (2008). Complexes Non-Covalents ADN:Polymères et Spectrométrie de Masse. Spectra Analyse, 264: 36-40.
  7. Oussedik, K., François, J. C., Halby, L. & Arimondo, P. B. (2007). Développement des Camptothécines Spécifiques de Séquences. Prostate Tumeur, 42: 14-16.

  1. Arimondo, P., Ferroud, C., Grellier, P., Guianvarc’h, D., Halby, L., Senamaud-Beaufort, C. (2010). Dérivés D'acide Aminobenzoïque Substitués Comme Inhibiteurs De Méthyltransférases De L’ADN. Patent no. PCT/EP2011/066305.
  2. Giovannangeli, C.,Marlin, F., Simon, P., Fontecave, M.,(2010). Flavin-Nucleic Acid Ligand Conjugates. Patent no. EP10305844.
  3. Arimondo, P., Guianvarc’h D, Ceccaldi A.; Senamaud-Beaufort C., Dauzonne D., Jeltsch A., Jurkowska R. (2009). Dérivés De Flavones Et Flavanones En Tant Qu'inhibiteurs D’ADN Méthyltransférases. Patent no. PCT/EP2010/063493.# Giovannangeli, C., Kurfurst R., Bonnet-Duquennoy M., Lazou K. (2007). Nouveaux Oligonucléotides Et Utilisation D'oligonucléotides Interagissant Avec Le Gène Codant Pour La Tyrosinase Related Protein-1. Patent no. PCT/EP2007/063355.
  4. Poulain, L., Gauduchon, P., Brotin, E. & Saison-Behmoaras, T. (2007). Cancer Therapy Using Bcl-Xl-Specific siRNA. Patent no. PCT/IB2007/002762.

  1. Site web d’assistance aux expériences d’édition du génome : crispor.tefor.org (100 000 visites depuis sa création) – Jean Paul Concordet, Maximilien Haeussler
  2. Logiciel d’analyse de séquences d’expérience d’édition du génome - Carine Giovannangeli, Evelyne Duvernois-Berthet, Julien Cochennec
  3. MassXpert Logiciel de simulation et d'analyse de données de spectrométrie de masse appliqué aux polymères (bio-)synthétiques F Rusconi
  4. TANGO Logiciel d'analyse d'image automatisée (2012) J. Ollion, J. Cochennec, F. Loll, C. Escudé and T. Boudier


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