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Publications Equipe SANTE        

Publications Equipe SANTE

Équipe 2 - Structures des Acides Nucléiques, Télomères et Evolution

Articles dans des revues internationales ou nationales avec comité de lecture


  1. Nozeret K, Loll F, Mouta Cardoso G, Escudé C, Boutorine AS. Interaction of fluorescently labeledpyrrole-imidazole polyamide probes with fixed and living murine andhuman cells. Biochimie. 2017; In Revision.
  2. Lancrey A, Safa L, Chatain J, Delagoutte E, Riou JF, Alberti P, Saintomé C. The binding of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimie. 2018; 146: 68-72.
  3. Saintomé C, Alberti P, Guinot N, Lejault P, Mailliet P, Riou JF, Bugaut A. Binding properties of mono- and dimeric pyridine dicarboxamideligands to human telomeric higher-order G-quadruplex structures. Chem Comm. 2018; In revision.


  1. Solé A, Delagoutte E, Ciudad CJ, Noé V, Alberti P. Polypurinereverse-Hoogsteen (PPRH) oligonucleotides can form triplexes withtheir target sequences even under conditions where they fold into G-quadruplexes. Sci Rep. 2017; 7:39898.
  2. Jdey W, Thierry S, Russo C, Devun F, Al Abo M, Noguiez-Hellin P, Sun JS, Barillot E, Zinovyev A, Kuperstein I, Pommier Y, Dutreix M. Drug-Driven Synthetic Lethality: Bypassing Tumor Cell Genetics witha Combination of Asi DNA and PARP Inhibitors. Clin Cancer Res. 2017;23: 1001-1011.
  3. Herath NI, Devun F, Lienafa MC, Herbette A, Denys A, Sun JS, Dutreix M. Potentiationof doxorubicin efficacy in hepatocellular carcinoma by the DNArepair inhibitor DT01 in preclinical models. Eur Radiol. 2017; Apr3. doi: 10. 1007/s00330-017-4792-1.
  4. Merghoub N, El Btaouri H, Benbacer L, Gmouh S, Trentesaux C, Brassart B, Attaleb M, Madoulet C, Wenner T, Amzazi S, Morjani H, El Mzibri M. Tomentosin Induces Telomere Shortening and Caspase-Dependant Apoptosis in Cervical Cancer Cells. J Cell Biochem. 2017; 118: 1689-1698.
  5. Terrien J, Gaudubois M, Champeval D, Zaninotto V, Roger L, Riou JF, Aujard F. Metabolic and genomic adaptation to winter fattening in aprimate species, the mouse lemur (Microcebus murinus). Int J Obes. 2017; in press, doi:10. 1038/ijo. 2017. 195.
  6. Hussain T, Saha D, Purohit G, Kar A, Mukherjee AK, Sharma S, Sengupta S, Dhapola P, Maji B, Vedagopuram S, Horikoshi NT, Horikoshi N, Pandita RK, Battacharya S, Bajaj A, Riou JF, Pandita TK, Chowdhury S. transcriptional control of CDKN1A(p21/CIP1/WAF1) by TRF2 through the REST repressor complex. Sci Rep. 2017; 7: 11541.


  1. Safa L, Gueddouda NM, Thiebaut F, Delagoutte E, Petruseva I, Lavrik O, Mendoza O, Bourdoncle A, Alberti P, Riou JF, Saintome C. 5' to 3' unfolding directionality of DNA secondary structures byreplication protein A: G-quadruplexes and duplexes. J Biol Chem. 2016; 291:21246-21256.
  2. Saintomé C, Amrane S, Mergny JL, Alberti P. The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium. Nucleic Acids Res. 2016; 44:2926-35.
  3. Herath NI, Devun F, Lienafa MC, Herbette A, Denys A, Sun JS, Dutreix M. The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis. Mol Cancer Ther. 2016; 15: 15-22.
  4. Viallard C, Chezal JM, Mishellany F, Ranchon-Cole I, Pereira B, Herbette A, Besse S, Boudhraa Z, Jacquemot N, Cayre A, Miot-Noirault E, Sun JS, Dutreix M, Degoul F. Targeting DNA repair by co Dbait enhancesmelanoma targeted radionuclide therapy. Oncotarget. 2016; 7: 12927-36.
  5. Le Tourneau C, Dreno B, Kirova Y, Grob JJ, Jouary T, Dutriaux C, Thomas L, Lebbé C, Mortier L, Saiag P, Avril MF, Maubec E, Joly P, Bey P, Cosset JM, Sun JS, Asselain B, Devun F, Marty ME, Dutreix M. First-in-human phase Istudy of the DNA-repair inhibitor DT01 in combination withradiotherapy in patients with skin metastases from melanoma. Br JCancer. 2016; 114: 1199-205.
  6. Merghoub N, El Btaouri H, Benbacer L, Gmouh S, Trentesaux C, Brassart B, Terryn C, Attaleb M, Madoulet C, Benjouad A, Amzazi S, El Mzibri M, Morjani H. Inula Viscosa Extracts Induces Telomere Shortening and Apoptosis in Cancer Cells and Overcome Drug Resistance. Nutr Cancer. 2016; 68: 131-43.
  7. Berthelot V, Mouta-Cardoso G, Hégarat N, Guillonneau F, François JC, Giovannangeli C, Praseuth D, Rusconi F. The human DNA ends proteome uncovers an unexpectedentanglement of functional pathways. Nucleic Acids Res. 2016;44:4721-33.


  1. Trochet D, Mergui X, Ivkovic I, Porreca RM, Gerbault-Seureau M, Sidibe A, Richard F, Londono-Vallejo A, Perret M, Aujard, F and Riou JF. Telomere regulation during ageing and tumorigenesis of the greymouse lemur. Biochimie. 2015; 113: 100-110.
  2. Bugaut A, Alberti P. Understandingthe stability of DNA G-quadruplex units in long human telomericstrands. Biochimie. 2015; 113:125-33.
  3. Audry J, Maestroni L, Delagoutte E, Gauthier T, Nakamura TM, Gachet Y, Saintomé C, Géli V, Coulon S. (2015) RPA prevents G4 structures at laggingstrand telomeres to allow maintenance of chromosome ends. EMBOJ. 2015; 34:1942-58.
  4. Laroche B, Detraz M, Blond A, Dubost L, Mailliet P, Nay B. Ring-Closing Enyne Metathesis of Terminal Alkynes with Propargylic Hindrance. J. Org. Chem. 2015; 80: 5359-5363.
  5. Jeitany M, Pineda JR, Liu Q, Porreca RM, Hoffschir F, Desmaze C, Silvestre DC, Mailliet P, Junier MP, Londoño-Vallejo A, Ségal-Bendirdjian E, Chneiweiss H, Boussin FD. A preclinical mouse model of glioma with an alternativemechanism of telomere maintenance (ALT). Int J Cancer. 2015; 136:1546-1558.


  1. Safa L, Delagoutte, E, Petruseva, I, Alberti, P, Lavrik, O, Riou, JF, Saintomé, C. Binding polarityof RPA to telomeric sequences and influence of G-quadruplexstability. Biochimie. 2014; 103:80-88.
  2. Valton, AL, Hassan-Zadeh V, Lema I, Boggetto N, Alberti P, Saintomé C, Riou JF, Prioleau MN. G4 motifsaffect origin positioning and efficiency in two vertebratereplicators. EMBOJ. 2014; 33:732-746.
  3. Cordier C, Boutimah F, Bourdeloux M, Dupuy F, Met E, Alberti P, Loll F, Chassaing G, Burlina F, Saison-Behmoaras TE. Delivery of antisense peptide nucleic acids to cells by conjugation withsmall arginine-rich cell-penetrating peptide (R/W)9. PloS One. 2014; 9: e104999.
  4. Moison C, Assemat F, Daunay A, Tost J, Guieysse-Peugeot AL, Arimondo PB. Synergistic epigenetic silencing of a tumor suppressorgene in human prostate cancer. Epigenetics. 2014; 9: 477-82.
  5. Asgatay S, Champion C, Marloie G, Drujon T, Senamaud-Beaufort C, Ceccaldi A, Erdmann A, Rajavelu A, Schambel P, Jeltsch A, Lequin O, Karoyan P, Arimondo PB, Guianvarc'h D. Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNAmethyltransferase 1. J Med Chem. 2014; 57: 421-434.
  6. Devun F, Biau J, Huerre M, Croset A, Sun JS, Denys A, Dutreix M. Colorectal cancer metastasis: the DNA repair inhibitor Dbait increases sensitivity to hyperthermia and improvesefficacy of radiofrequency ablation. Radiology. 2014; 270: 736-46.
  7. Biau J, Devun F, Jdey W, Kotula E, Quanz M, Chautard E, Sayarath M, Sun JS, Verrelle P, Dutreix M. A preclinical study combining the DNA repairinhibitor Dbait with radiotherapy for the treatment of melanoma. Neoplasia. 2014; 16: 835-44.


  1. Vrignaud P, Semiond D, Lejeune P, Bouchard H, Calvet L, Combeau C, Riou JF, Commerçon A, Lavelle F, Bissery MC. Preclinicalantitumor activity of cabazitaxel, a semisynthetic taxane active intaxane-resistant tumors. Clin Cancer Res. 2013; 19:2973-2983.
  2. Douarre C, Mergui X, Sidibe A, Gomez D, Alberti P, Mailliet P, Trentesaux C, Riou JF. DNA damage signaling induced by the G-quadruplex ligand 12459 ismodulated by PPM1D/WIP1 phosphatase. Nucleic Acids Res. 2013; 41:3588-3599.
  3. Moison C, Senamaud-Beaufort C, Fourrière L, Champion C, Ceccaldi A, Lacomme S, Daunay A, Tost J, Arimondo PB, Guieysse-Peugeot AL. DNAmethylation associated with polycomb repression in retinoic acidreceptor beta silencing. Faseb J. 2013; 27:1468-1478.
  4. Croset A, Cordelières FP, Berthault N, Buhler C, Sun JS, Quanz M, Dutreix M. Inhibition of DNA damage repair by artificialactivation of PARP with si DNA. Nucleic Acids Res. 2013; 41: 7344-55.
  5. Kotula E, Faigle W, Berthault N, Dingli F, Loew D, Sun JS, Dutreix M, Quanz M. DNA-PK target identification reveals novel linksbetween DNA repair signaling and cytoskeletal regulation. PloS One. 2013; 8: e80313.


  1. Halder, R., Riou, J. F., Teulade-Fichou, M. P., Frickey, T. & Hartig, J. S. (2012). Bisquinolinium Compounds Induce Quadruplex-Specific Transcriptome Changes in Hela S3 Cell Line. BMC Research Note, 5: 138.
  2. Huijbregts, L., Roze, C., Bonafe, G., Houang, M., Le Bouc, Y., Carel, J. C., Leger, J., Alberti, P. & Roux, N. (2012). DNA Polymorphisms of the KISS1 3' Untranslated Region Interfere with the Folding of a G-Rich Sequence into G-Quadruplex. Mol Cell Endocrinol, 351, 2: 239-48. (IF: 3,68)
  3. Marlin, F., Simon, P., Bonneau, S., Alberti, P., Cordier, C., Boix, C., Perrouault, L., Fossey, A., Saison-Behmoaras, T., Fontecave, M. & GIovannangeli, C. (2012). Flavin Conjugates for Delivery of Peptide Nucleic Acids. ChemBioChem: in press DOI: 10.1002;cbic.201200505. (IF: 3,72)
  4. Muller, S., Sander, D. A., Di Antonio, M., Matsis, S., Riou, J. F., Rodriguez, R. & Balasubramanian, S. (2012). Pyridostatin Analogues Promote Telomere Dysfunction and Long-Term Growth Inhibition in Human Cancer Cells. Org Biomol Chem, 10: 6537-46. (IF: 3,65)
  5. Sidibe, A., Hamon, F., Largy, E., Gomez, D., Teulade-Fichou, M. P., Trentesaux, C. & Riou, J. F. (2012). Effects of a Halogenated G-Quadruplex Ligand from the Pyridine Dicarboxamide Series on the Terminal Sequence of XPYP Telomere in HT1080 Cells. Biochimie: in press PMID: 22796264. (IF: 3,42)
  6. Bertrand, H., Granzhan, A., Monchaud, D., Saettel, N., Guillot, R., Clifford, S., Guedin, A., Mergny, J. L. & Teulade-Fichou, M. P. (2011). Recognition of G-Quadruplex DNA by Triangular Star-Shaped Compounds: With or without Side Chains? Chemistry, 17, 16: 4529-39. (IF: 5,87)
  7. Hamon, F., Largy, E., Guedin-Beaurepaire, A., Rouchon-Dagois, M., Sidibe, A., Monchaud, D., Mergny, J. L., Riou, J. F., Nguyen, C. H. & Teulade-Fichou, M. P. (2011). An Acyclic Oligoheteroaryle That Discriminates Strongly between Diverse G-Quadruplex Topologies. Angew Chem Int Ed Engl, 50, 37: 8745-9. (IF: 13,2)
  8. Lacroix, L., Seosse, A. & Mergny, J. L. (2011). Fluorescence-Based Duplex-Quadruplex Competition Test to Screen for Telomerase RNA Quadruplex Ligands. Nucleic Acids Res, 39, 4: e21. (IF: 7,42)
  9. Marcel, V., Tran, P. L., Sagne, C., Martel-Planche, G., Vaslin, L., Teulade-Fichou, M. P., Hall, J., Mergny, J. L., Hainaut, P. & Van Dyck, E. (2011). G-Quadruplex Structures in Tp53 Intron 3: Role in Alternative Splicing and in Production of P53 mRNA Isoforms. Carcinogenesis, 32, 3: 271-8. (IF: 5,2)
  10. Merle, P., Evrard, B., Petitjean, A., Lehn, J. M., Teulade-Fichou, M. P., Chautard, E., De Cian, A., Guittat, L., Tran, P. L., Mergny, J. L., Verrelle, P. & Tchirkov, A. (2011). Telomere Targeting with a New G4 Ligand Enhances Radiation-Induced Killing of Human Glioblastoma Cells. Mol Cancer Ther, 10, 10: 1784-95. (IF: 5,39)
  11. Tran, P. L., Largy, E., Hamon, F., Teulade-Fichou, M. P. & Mergny, J. L. (2011). Fluorescence Intercalator Displacement Assay for Screening G4 Ligands Towards a Variety of G-Quadruplex Structures. Biochimie, 93, 8: 1288-96. (IF: 3,42)
  12. Tran, P. L., Mergny, J. L. & Alberti, P. (2011). Stability of Telomeric G-Quadruplexes. Nucleic Acids Res, 39, 8: 3282-94. (IF: 7,42)
  13. Tran, P. L., Virgilio, A., Esposito, V., Citarella, G., Mergny, J. L. & Galeone, A. (2011). Effects of 8-Methylguanine on Structure, Stability and Kinetics of Formation of Tetramolecular Quadruplexes. Biochimie, 93, 3: 399-408. (IF: 3,42)
  14. Gomez, D., Guedin, A., Mergny, J. L., Salles, B., Riou, J. F., Teulade-Fichou, M. P. & Calsou, P. (2010). A G-Quadruplex Structure within the 5'-UTR of TRF2 mRNA Represses Translation in Human Cells. Nucleic Acids Res, 38, 20: 7187-98. (IF: 7,42)
  15. Granzhan, A., Monchaud, D., Saettel, N., Guedin, A., Mergny, J. L. & Teulade-Fichou, M. P. (2010). One Ring to Bind Them All. Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles. J Nucleic Acids, 2010: 460561.
  16. Guedin, A., Gros, J., Alberti, P. & Mergny, J. L. (2010). How Long Is Too Long? Effects of Loop Size on G-Quadruplex Stability. Nucleic Acids Res, 38, 21: 7858-68. (IF: 7,42)
  17. Guedin, A., Lacroix, L. & Mergny, J. L. (2010). Thermal Melting Studies of Ligand-DNA Interactions. Methods Mol Biol, 613: 25-35. (IF: 13,9)
  18. Hampel, S. M., Sidibe, A., Gunaratnam, M., Riou, J. F. & Neidle, S. (2010). Tetrasubstituted Naphthalene Diimide Ligands with Selectivity for Telomeric G-Quadruplexes and Cancer Cells. Bioorg Med Chem Lett, 20, 22: 6459-63. (IF: 2,54)
  19. Laronze-Cochard, M., Cochard, F., Daras, E., Lansiaux, A., Brassart, B., Vanquelef, E., Prost, E., Nuzillard, J. M., Baldeyrou, B., Goosens, J. F., Lozach, O., Meijer, L., Riou, J. F., Henon, E. & Sapi, J. (2010). Synthesis and Biological Evaluation of New Penta- and Heptacyclic Indolo- and Quinolinocarbazole Ring Systems Obtained via Pd(0) Catalysed Reductive N-Heteroannulation. Org Biomol Chem, 8, 20: 4625-36. (IF: 3,65)
  20. Monchaud, D., Granzhan, A., Saettel, N., Guedin, A., Mergny, J. L. & Teulade-Fichou, M. P. (2010). One Ring to Bind Them All. Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition. J Nucleic Acids, 2010: 525862.
  21. Reinhold, W. C., Mergny, J. L., Liu, H., Ryan, M., Pfister, T. D., Kinders, R., Parchment, R., Doroshow, J., Weinstein, J. N. & Pommier, Y. (2010). Exon Array Analyses across the NCI-60 Reveal Potential Regulation of Top1 by Transcription Pausing at Guanosine Quartets in the First Intron. Cancer Res, 70, 6: 2191-203. (IF: 8,16)
  22. Trentesaux, C. & Riou, J. F. (2010). Senescence and Cellular Immortality. Bull Cancer, 97, 11: 1275-83. (IF: 0,64)
  23. Bertrand, H., Bombard, S., Monchaud, D., Talbot, E., Guedin, A., Mergny, J. L., Grunert, R., Bednarski, P. J. & Teulade-Fichou, M. P. (2009). Exclusive Platination of Loop Adenines in the Human Telomeric G-Quadruplex. Org Biomol Chem, 7, 14: 2864-71. (IF: 3,65)
  24. Cuenca, F., Moore, M. J., Johnson, K., Guyen, B., De Cian, A. & Neidle, S. (2009). Design, Synthesis and Evaluation of 4,5-Di-Substituted Acridone Ligands with High G-Quadruplex Affinity and Selectivity, Together with Low Toxicity to Normal Cells. Bioorg Med Chem Lett, 19, 17: 5109-13. (IF: 2,54)
  25. El Bakali, J., Klupsch, F., Guedin, A., Brassart, B., Fontaine, G., Farce, A., Roussel, P., Houssin, R., Bernier, J. L., Chavatte, P., Mergny, J. L., Riou, J. F. & Henichart, J. P. (2009). 2,6-Diphenylthiazolo3,2-b1,2,4Triazoles as Telomeric G-Quadruplex Stabilizers. Bioorg Med Chem Lett, 19, 13: 3434-8. (IF: 2,54)
  26. Guedin, A., Alberti, P. & Mergny, J. L. (2009). Stability of Intramolecular Quadruplexes: Sequence Effects in the Central Loop. Nucleic Acids Res, 37, 16: 5559-67. (IF: 7,42)
  27. Laronze-Cochard, M., Kim, Y. M., Brassart, B., Riou, J. F., Laronze, J. Y. & Sapi, J. (2009). Synthesis and Biological Evaluation of Novel 4,5-Bis(Dialkylaminoalkyl)-Substituted Acridines as Potent Telomeric G-Quadruplex Ligands. Eur J Med Chem, 44, 10: 3880-8. (IF: 3,51)
  28. Lim, K. W., Alberti, P., Guedin, A., Lacroix, L., Riou, J. F., Royle, N. J., Mergny, J. L. & Phan, A. T. (2009). Sequence Variant (CTAGGG)n in the Human Telomere Favors a G-Quadruplex Structure Containing a G.C.G.C Tetrad. Nucleic Acids Res, 37, 18: 6239-48. (IF: 7,42)
  29. Mendez-Bermudez, A., Hills, M., Pickett, H. A., Phan, A. T., Mergny, J. L., Riou, J. F. & Royle, N. J. (2009). Human Telomeres That Contain (CTAGGG)n Repeats Show Replication Dependent Instability in Somatic Cells and the Male Germline. Nucleic Acids Res, 37, 18: 6225-38. (IF: 7,42)
  30. Mergny, J. L. & Lacroix, L. (2009). UV Melting of G-Quadruplexes. Curr Protoc Nucleic Acid Chem, Chapter 17: Unit 17 1.
  31. Ribeyre, C., Lopes, J., Boule, J. B., Piazza, A., Guedin, A., Zakian, V. A., Mergny, J. L. & Nicolas, A. (2009). The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences in Vivo. PLoS Genet, 5, 5: e1000475. (IF: 9,17)
  32. Riou, J. F. (2009). Three Pioneers of Science Rewarded for the Beginning of the End of Chromosomes. Bull Cancer, 96, 11: 1033-34. (IF: 0,64)
  33. Stegle, O., Payet, L., Mergny, J. L., MacKay, D. J. & Leon, J. H. (2009). Predicting and Understanding the Stability of G-Quadruplexes. Bioinformatics, 25, 12: i374-82. (IF: 6,05)
  34. Temime-Smaali, N., Guittat, L., Sidibe, A., Shin-ya, K., Trentesaux, C. & Riou, J. F. (2009). The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase III-alpha to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells. PLoS One, 4, 9: e6919. (IF: 4,54)
  35. Yang, P., De Cian, A., Teulade-Fichou, M. P., Mergny, J. L. & Monchaud, D. (2009). Engineering Bisquinolinium:Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA. Angew Chem Int Ed Engl, 48, 12: 2188-91. (IF: 13,2)
  36. Amrane, S., De Cian, A., Rosu, F., Kaiser, M., De Pauw, E., Teulade-Fichou, M. P. & Mergny, J. L. (2008). Identification of Trinucleotide Repeat Ligands with a FRET Melting Assay. ChemBioChem, 9, 8: 1229-34. (IF: 3,72)
  37. Chaires, J. B. & Mergny, J. L. (2008). Targeting DNA. Biochimie, 90, 7: 973-5. (IF: 3,42)
  38. Cheng, M. K., Modi, C., Cookson, J. C., Hutchinson, I., Heald, R. A., McCarroll, A. J., Missailidis, S., Tanious, F., Wilson, W. D., Mergny, J. L., Laughton, C. A. & Stevens, M. F. (2008). Antitumor Polycyclic Acridines. 20. Search for DNA Quadruplex Binding Selectivity in a Series of 8,13-Dimethylquino4,3,2-klAcridinium Salts: Telomere-Targeted Agents. J Med Chem, 51, 4: 963-75. (IF: 5,32)
  39. De Cian, A., Grellier, P., Mouray, E., Depoix, D., Bertrand, H., Monchaud, D., Teulade-Fichou, M. P., Mergny, J. L. & Alberti, P. (2008). Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds. ChemBioChem, 9, 16: 2730-9. (IF: 3,72)
  40. De Cian, A., Gros, J., Guedin, A., Haddi, M., Lyonnais, S., Guittat, L., Riou, J. F., Trentesaux, C., Saccà, B., Lacroix, L., Alberti, P. & Mergny, J. L. (2008). DNA and RNA Quadruplex Ligands. Nucleic Acids Symp Ser (Oxf), 52: 39666.
  41. De Cian, A., Lacroix, L., Douarre, C., Temime-Smaali, N., Trentesaux, C., Riou, J. F. & Mergny, J. L. (2008). Targeting Telomeres and Telomerase. Biochimie, 90, 1: 131-55. (IF: 3,42)
  42. Gros, J., Avino, A., Lopez de la Osa, J., Gonzalez, C., Lacroix, L., Perez, A., Orozco, M., Eritja, R. & Mergny, J. L. (2008). 8-Amino Guanine Accelerates Tetramolecular G-Quadruplex Formation. Chem Commun (Camb), 25: 2926-8. (IF: 6,08)
  43. Gros, J., Guedin, A., Mergny, J. L. & Lacroix, L. (2008). G-Quadruplex Formation Interferes with P1 Helix Formation in the RNA Component of Telomerase hTERC. ChemBioChem, 9, 13: 2075-9. (IF: 3,72)
  44. Guedin, A., De Cian, A., Gros, J., Lacroix, L. & Mergny, J. L. (2008). Sequence Effects in Single-Base Loops for Quadruplexes. Biochimie, 90, 5: 686-96. (IF: 3,42)
  45. Lyonnais, S., Pietrement, O., Chepelianski, A., Gueron, S., Lacroix, L., Le Cam, E. & Mergny, J. L. (2008). Functionalization of DNA G-Wires for Patterning and Nanofabrication. Nucleic Acids Symp Ser (Oxf), 52: 689-90.
  46. Mazzucchelli, G., Gabelica, V., Smargiasso, N., Rosu, F., De Pauw-Gillet, M. C., Riou, J. F. & De Pauw, E. (2008). Proteomic Analysis of Telomerase Inhibition by Telomere Specific Ligands. Anticancer Research, 28, 5C: 3257-58. (IF: 1,55)
  47. Mazzucchelli, G. D., Gabelica, V., Smargiasso, N., Fleron, M., Ashimwe, W., Rosu, F., De Pauw-Gillet, M. C., Riou, J. F. & De Pauw, E. (2008). Proteome Alteration Induced by hTERT Transfection of Human Fibroblast Cells. Proteome Sci, 6: 12. (IF: 2,57)
  48. Mills, M., Mergny, J. L. & Klump, H. H. (2008). From Quadruplex to Helix and Back: Meta-Stable States Can Move through a Cycle of Conformational Changes. Arch Biochem Biophys, 474, 1: 40390. (IF: 2,89)
  49. Monchaud, D., Allain, C., Bertrand, H., Smargiasso, N., Rosu, F., Gabelica, V., De Cian, A., Mergny, J. L. & Teulade-Fichou, M. P. (2008). Ligands Playing Musical Chairs with G-Quadruplex DNA: A Rapid and Simple Displacement Assay for Identifying Selective G-Quadruplex Binders. Biochimie, 90, 8: 1207-23. (IF: 3,42)
  50. Monchaud, D., Yang, P., Lacroix, L., Teulade-Fichou, M. P. & Mergny, J. L. (2008). A Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity. Angew Chem Int Ed Engl, 47, 26: 4858-61. (IF: 13,2)
  51. Rodriguez, R., Muller, S., Yeoman, J. A., Trentesaux, C., Riou, J. F. & Balasubramanian, S. (2008). A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres. J Am Chem Soc, 130, 47: 15758-9. (IF: 9,77)
  52. Rosu, F., Gabelica, V., De Pauw, E., Mailliet, P. & Mergny, J. L. (2008). Cooperative 2:1 Binding of a Bisphenothiazine to Duplex DNA. ChemBioChem, 9, 6: 849-52. (IF: 3,72)
  53. Temime-Smaali, N., Guittat, L., Wenner, T., Bayart, E., Douarre, C., Gomez, D., Giraud-Panis, M. J., Londono-Vallejo, A., Gilson, E., Amor-Gueret, M. & Riou, J. F. (2008). Topoisomerase III-alpha Is Required for Normal Proliferation and Telomere Stability in Alternative Lengthening of Telomeres. EMBO J, 27, 10: 1513-24. (IF: 8,83)
  54. Arnoult, N., Saintome, C., Ourliac-Garnier, I., Riou, J. F. & Londono-Vallejo, A. (2009). Human POT1 Is Required for Efficient Telomere C-Rich Strand Replication in the Absence of WRN. Genes & Development, 23, 24: 2915-24. (IF: 12,79)
  55. Bates, P., Mergny, J. L. & Yang, D. (2007). Quartets in G-Major. The First International Meeting on Quadruplex DNA. EMBO Rep, 8, 11: 1003-10. (IF: 7,37)
  56. Bertrand, H., Monchaud, D., De Cian, A., Guillot, R., Mergny, J. L. & Teulade-Fichou, M. P. (2007). The Importance of Metal Geometry in the Recognition of G-Quadruplex-DNA by Metal-Terpyridine Complexes. Org Biomol Chem, 5, 16: 2555-9. (IF: 3,65)
  57. Brassart, B., Gomez, D., De Cian, A., Paterski, R., Montagnac, A., Qui, K. H., Temime-Smaali, N., Trentesaux, C., Mergny, J. L., Gueritte, F. & Riou, J. F. (2007). A New Steroid Derivative Stabilizes G-Quadruplexes and Induces Telomere Uncapping in Human Tumor Cells. Mol Pharmacol, 72, 3: 631-40. (IF: 4,58)
  58. Dasse, E., Bridoux, L., Baranek, T., Lambert, E., Salesse, S., Sowa, M. L., Martiny, L., Trentesaux, C. & Petitfrere, E. (2007). Tissue Inhibitor of Metalloproteinase-1 Promotes Hematopoietic Differentiation Via Caspase-3 Upstream the MEKK1:MEK6:P38-alpha Pathway. Leukemia, 21, 4: 595-603. (IF: 8,21)
  59. De Cian, A., Cristofari, G., Reichenbach, P., De Lemos, E., Monchaud, D., Teulade-Fichou, M. P., Shin-Ya, K., Lacroix, L., Lingner, J. & Mergny, J. L. (2007). Reevaluation of Telomerase Inhibition by Quadruplex Ligands and Their Mechanisms of Action. Proc Natl Acad Sci U S A, 104, 44: 17347-52. (IF: 10,47)
  60. De Cian, A., Delemos, E., Mergny, J. L., Teulade-Fichou, M. P. & Monchaud, D. (2007). Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds. J Am Chem Soc, 129, 7: 1856-7. (IF: 9,77)
  61. De Cian, A., Guittat, L., Kaiser, M., Saccà, B., Amrane, S., Bourdoncle, A., Alberti, P., Teulade-Fichou, M. P., Lacroix, L. & Mergny, J. L. (2007). Fluorescence-Based Melting Assays for Studying Quadruplex Ligands. Methods, 42, 2: 183-95. (IF: 4,48)
  62. De Cian, A. & Mergny, J. L. (2007). Quadruplex Ligands May Act as Molecular Chaperones for Tetramolecular Quadruplex Formation. Nucleic Acids Res, 35, 8: 2483-93. (IF: 7,42)
  63. Gros, J., Rosu, F., Amrane, S., De Cian, A., Gabelica, V., Lacroix, L. & Mergny, J. L. (2007). Guanines Are a Quartet's Best Friend: Impact of Base Substitutions on the Kinetics and Stability of Tetramolecular Quadruplexes. Nucleic Acids Res, 35, 9: 3064-75. (IF: 7,42)
  64. Gunaratnam, M., Greciano, O., Martins, C., Reszka, A. P., Schultes, C. M., Morjani, H., Riou, J. F. & Neidle, S. (2007). Mechanism of Acridine-Based Telomerase Inhibition and Telomere Shortening. Biochem Pharmacol, 74, 5: 679-89. (IF: 4,69)
  65. Hounsou, C., Guittat, L., Monchaud, D., Jourdan, M., Saettel, N., Mergny, J. L. & Teulade-Fichou, M. P. (2007). G-Quadruplex Recognition by Quinacridines: A SAR, NMR, and Biological Study. ChemMedChem, 2, 5: 655-66. (IF: 3,45)
  66. Mergny, J. L., Lacroix, L. & Riou, J. F. (2007). Telomerase: A Dimeric Menage a Trois. ChemBioChem, 8, 13: 1483-5. (IF: 3,72)
  67. Yatouji, S., El-Khoury, V., Trentesaux, C., Trussardi-Regnier, A., Benabid, R., Bontems, F. & Dufer, J. (2007). Differential Modulation of Nuclear Texture, Histone Acetylation, and MDR1 Gene Expression in Human Drug-Sensitive and -Resistant OV1 Cell Lines. Int J Oncol, 30, 4: 1003-9. (IF: 2,53)


Autres publications

  1. Saintomé, C. Télomères et télomérases : une diversité structurale pour un même rôle. In « Evolution et Biodiversité (Ed. Philippe Grandcolas et Marie-Christine Maurel), 2017, ISTE Editions, Londres.
  2. Bugaut, A. Biological relevance and small molecule targeting of RNA G-quadruplexes in the human genome. In Biological relevance and therapeutic applications of DNA- and RNA G-quadruplexes. (ed. D. Monchaud) 2015 ; pp118-132. Future Science Ltd.
  3. Amor-Gueret, M, Riou, JF. Topoisomerases and Carcinogenesis: Topoisomerase III-alpha and BLM. In DNA Topoisomerases and Cancer. (ed. Y. Pommier) 2012 ; chapter 8 pp. 155-74. Humana Press. ISBN 978-1-4614-0322-7.
  4. Trentesaux, C, Trochet, D, Alberti, P, Riou, JF. Le Ciblage de la Telomerase et des Telomères. In Thérapie Ciblée des Cancers : Les Cibles Nucléaires en Oncologie. (ed. A. Kahn) 2012 ; pp. 30-44. John Libbey Eurotext. ISBN 978-2-7420-0766-0.

  1. Moison C, Guieysse-Peugeot AL, Arimondo PB, DNA methylation in cancer. Atlas Genet Cytogenet Oncol Haematol. 2014; 18: 285-292.

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  2. Mailliet P, Marinetti A, Skander A. Platinum N-Heterocylic carbene derivatives, preparation thereof and therapeutic use thereof. US 8, 980, 875 B2(Mar 17, 2015).
  3. Dutreix M, Jdey W, Sun JS. Useof a combination of Dbait molecule and PARP inhibitors to treat Cancer. EP15306201. 3 (Jul 23, 2015)
  4. Rouchon-Dagois, M., Nguyen, C. H., Teulade-Fichou, M. P., Monchaud, D., Guedin, A., Mergny, J. L., Riou, J. F. & Grierson, D. S. (2008). Poly-Heteroaryl Derivatives for the Treatment of Cancer. Patent no. PCT/IB2009/054856.


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