Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
Safa Layal, Gueddouda Nassima Meriem, Thiébaut Frédéric, Delagoutte Emmanuelle, Petruseva Irina, Lavrik Olga, Mendoza Oscar, Bourdoncle Anne, Alberti Patrizia, Riou Jean-François & Saintomé Carole, 2016 — 5’ to 3’ Unfolding Directionality of DNA Secondary Structures by Replication Protein A. Journal of Biological Chemistryvol. 291, n° 40, dir. {American Society for Biochemistry and Molecular Biology}p. 21246-21256
Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, September 2021 — Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3’ toward 5’, a feature due to a 3’-end binding preference and to structuring of telomeric DNA. Nucleic Acids Researchvol. 49, , dir. {Oxford University Press}p. 10735-10746
Chatain Jean, Blond Alain, Phan Anh Tuân, Saintomé Carole & Alberti Patrizia, July 2021 — GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Research , , dir. {Oxford University Press}
Saintomé C., Alberti Patrizia, Guinot N., Lejault P., Chatain J., Mailliet P., Riou Jean-Francois & Bugaut A., 2018 — Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures. Chemical Communicationsvol. 54, n° 15, dir. {Royal Society of Chemistry}p. 1897-1900
Fernandes Carlos AH, Morea Edna Gicela O, Dos Santos Gabriel A, da Silva Vitor L, Vieira Marina Roveri, Viviescas Maria Alejandra, Chatain Jean, Vadel Aurelie, Saintome Carole, Fontes Marcos Roberto M & others, 2020 — A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis. Biochimica et Biophysica Acta (BBA)-General Subjectsvol. 1864, n° 7, p. 129607
Aklilu Behailu, Peurois François, Saintomé Carole, Culligan Kevin, Kobbe Daniela, Leasure Catherine, Chung Michael, Cattoor Morgan, Lynch Ryan, Sampson Lauren, Fatora John & Shippen Dorothy, August 2020 — Functional Diversification of Replication Protein A Paralogs and Telomere Length Maintenance in Arabidopsis. Geneticsvol. 215, n° 4, p. 989-1002
Saintomé Carole, Amrane Samir, Mergny Jean-louis & Alberti Patrizia, January 2016 — The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium. Nucleic Acids Researchvol. 44, n° 6, dir. {Oxford University Press}p. 2926-2935
Lancrey Astrid, Safa Layal, Chatain Jean, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, March 2018 — The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimievol. 146, , dir. {Elsevier}p. 68-72
Saintomé Carole & Delagoutte Emmanuelle, August 2018 — Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins. PLoS ONEvol. 13, n° 8, dir. {Public Library of Science}e0202138