Research in the "Structure and Instability of Genomes" laboratory focuses on nucleic acids, their structures, their dynamics and their interactions with different cellular partners. Our work aims to characterize, at the molecular level, the cellular functions associated with nucleic acids, in particular the molecular mechanisms of genomic instability, involved in various pathological and evolutionary processes.
The specificity of our research is to exploit our expertise at the interface between chemistry, biophysics, biochemistry and biology, by implementing multidisciplinary approaches.
Our work is carried out at different scales of integration: the single molecule, the cell (bacteria, fungi, rodents, primates, humans), as well as several original models (tardigrades, food microbial consortia). Our research is currently organized around 4 teams.