Presentation

Research in the "Structure and Instability of Genomes" laboratory focuses on nucleic acids, their structures, their dynamics and their interactions with different cellular partners. Our work aims to characterize, at the molecular level, the cellular functions associated with nucleic acids, in particular the molecular mechanisms of genomic instability, involved in various pathological and evolutionary processes.

The specificity of our research is to exploit our expertise at the interface between chemistry, biophysics, biochemistry and biology, by implementing multidisciplinary approaches.

Our work is carried out at different scales of integration: the single molecule, the cell (bacteria, fungi, rodents, primates, humans), as well as several original models (tardigrades, food microbial consortia). Our research is currently organized around 4 teams.

• GE2R - Genome Editing, DNA double-strand break Repair and cellular Responses
• SANTE - Structures des Acides Nucléiques, Télomères et Evolution
• ARChE - ADN Répété, Chromatine, Evolution
• GPA - Génomique et Physiologie de l' Adaptation

Historical : Our laboratory (under the tutelage of CNRS, INSERM and MNHN)  is part of the Biophysics laboratory of the National Museum of Natural History, created in 1961 by Charles Sadron and developed by Claude Hélène, both internationally renowned molecular biophysicists, in particular in the field of nucleic acids, and pioneers of interdisciplinarity. Its experimental approaches combine different disciplines, mainly biophysics, chemistry and biology.

Organigramme de l'unité

Organigramme UMR7196

Credits

©J.B-Boulé