SANTE

Structure of Nucleic Acids, Telomeres and Evolution
Présentation de l’équipe
Team Members:
Former Members:
Structures de l'ADN télomérique et interaction avec des protéines de liaison à l'ADN simple-brin par des approches in vitro
Régulation des fonctions télomériques par des approches cellulaires
Generalizing and improving the use of enhanced bioluminescent reporting systems
Illustrations of the different themes of the team
Main collaborations
Selected publications:
Bossaert M*, Pipier A*, Riou J-F, Noirot C, Nguyen L-T, Serre R-F, Bouchez O, Defrancq E, Calsou P, Britton S, Gomez D. Transcription-associated topoisomerase 2a (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands. eLife. 2021; 10: e65184.
Bugaut A, Alberti P. Understanding the stability of DNA G-quadruplex units in long human telomeric strands. Biochimie. 2015; 113:125-33.
Chatain J, Blond A, Phan AT, Saintomé C, Alberti P. GGGCTA repeats can fold into hairpins poorly unfolded by Replication Protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Res. 2021; in press.
Hwang IP, Mailliet P, Hossard V, Riou JF, Bugaut A, Roger L. Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA). Molecules. 2019; 24(3):577.
Lancrey A, Safa L, Chatain J, Delagoutte E, Riou JF, Alberti P, Saintomé C. The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimie. 2018; 146:68-72.
Le Berre G, Hossard V, Riou JF, Guieysse-Peugeot AL. Repression of TERRA Expression by Subtelomeric DNA Methylation Is Dependent on NRF1 Binding. Int J Mol Sci. 2019;20(11):2791.
Lejault P. Ligands de la jonction double-brin/simple-brin de l’ADN télomérique comme sondes moléculaires pour étudier la biologie des télomères. PhD Thesis, ED 227 MNHN, 20 Nov 2017.
Pipier A, Devaux A, lavergne T, Adrait A, Couté Y, Britton S, Calsou P, Riou J-F, Defrancq E, Gomez D. Constrained G4 structures unveil topology specificity of known and new G4 binding proteins. Scientific Report. 2021; 11:13469
Subecz C, Sun JS, Roger L. Effect of DNA repair inhibitor AsiDNA on the incidence of telomere fusion in crisis. Hum Mol Genet. 2021; 30(3-4):172-181.
Trochet D, Mergui X, Ivkovic I, Porreca RM, Gerbault-Seureau M, Sidibe A, Richard F, Londono-Vallejo A, Perret M, Aujard F, Riou JF. Telomere regulation during ageing and tumorigenesis of the grey mouse lemur. Biochimie. 2015; 113:100-10.