Patrizia ALBERTI
Lecturer
Affiliation entity
Équipe SANTÉ
Contact
E-mail
patrizia.alberti [at] mnhn.fr
Phone
01 40 79 37 27
Address(es)
CNRS UMR 7196 / INSERM U1154
43, rue Cuvier - Case Postale 26
75231 Paris Cedex 05, France
Responsibilities inside unit
Directrice Adjointe
Responsable du Pôle Biophysique
Teaching
Enseignement dans le cadre du Master BEE (Biodiversité, Écologie et Évolution) du Muséum :
- M2 : Participation à l’UE d’analyse scientifique et au jury de soutenance de stage de la finalité Molécules et Cibles Thérapeutiques du parcours Environnement et Santé
- M1 : Participation au jury de soutenances de stage du parcours Environnement et Santé
- M1 : Encadrement des TD de l’UE Travailler en mode projet du Tronc Commun 1 Sciences de la Nature et de l’Homme : histoire des idées et participation au jury de l’examen de validation
- M1 : Animation des TD de l’UE Développer mon Projet Professionnel et Personnel
Projects
My main research focus is the characterisation of non-canonical nucleic acid structures (such as G-quadruplexes) and how proteins interact with them. I am particularly interested in repeated sequences and in the evolution of telomeres (the nucleoprotein structures that protect the ends of eukaryotic chromosomes), a fascinating illustration of the unity and diversity of Life.
Publications
2021
- , September 2021 — Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3’ toward 5’, a feature due to a 3’-end binding preference and to structuring of telomeric DNA. Nucleic Acids Research vol. 49, , dir. {Oxford University Press} p. 10735-10746
- , July 2021 — GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Research , , dir. {Oxford University Press}
- , April 2021 — PfGBP2 is a novel G-quadruplex binding protein in Plasmodium falciparum. Cellular Microbiology vol. 23, n° 4, dir. {Wiley} e13303
- , 2021 — Folding and persistence times of intramolecular G-quadruplexes transiently embedded in a DNA duplex. Nucleic Acids Research , , dir. {Oxford University Press}
2020
- , July 2020 — Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites. PLoS Genetics vol. 16, n° 7, dir. {Public Library of Science} e1008917
2018
- , March 2018 — The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimie vol. 146, , dir. {Elsevier} p. 68-72
- , 2018 — Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures. Chemical Communications vol. 54, n° 15, dir. {Royal Society of Chemistry} p. 1897-1900
2017
- , February 2017 — Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes. Scientific Reports vol. 7, n° 1, dir. {Nature Publishing Group}
2016
- , 2016 — 5’ to 3’ Unfolding Directionality of DNA Secondary Structures by Replication Protein A. Journal of Biological Chemistry vol. 291, n° 40, dir. {American Society for Biochemistry and Molecular Biology} p. 21246-21256
- , January 2016 — The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium. Nucleic Acids Research vol. 44, n° 6, dir. {Oxford University Press} p. 2926-2935