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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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    • GE2R _ Genome Editing, DNA double-strand break Repair and cellular Responses
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Safa Layal, Gueddouda Nassima Meriem, Thiébaut Frédéric, Delagoutte Emmanuelle, Petruseva Irina, Lavrik Olga, Mendoza Oscar, et al. 2016. “5’ to 3’ Unfolding Directionality of DNA Secondary Structures by Replication Protein A”. Journal of Biological Chemistry 291 (January). {American Society for Biochemistry and Molecular Biology}: 21246-56. doi:10.1074/jbc.M115.709667.
https://dx.doi.org/10.1074/jbc.M115.709667
Marlin Fanny, Simon Philippe, Bonneau Stéphanie, Alberti Patrizia, Cordier Céline, Boix Charlotte, Perrouault Loïc, et al. 2012. “Flavin Conjugates for Delivery of Peptide Nucleic Acids”. ChemBioChem 13 (November). {Wiley-VCH Verlag}. doi:10.1002/cbic.201200505.
https://dx.doi.org/10.1002/cbic.201200505
Tran Phong Lan Thao, Mergny Jean-Louis, and Alberti Patrizia. 2011. “Stability of Telomeric G-Quadruplexes”. Nucleic Acids Research 39 (April). {Oxford University Press}: 3282-94. doi:10.1093/nar/gkq1292.
https://dx.doi.org/10.1093/nar/gkq1292
Solé Anna, Delagoutte Emmanuelle, Ciudad Carlos, Noé Véronique, and Alberti Patrizia. 2017. “Polypurine Reverse-Hoogsteen (PPRH) Oligonucleotides Can Form Triplexes With Their Target Sequences Even under Conditions Where They Fold into G-Quadruplexes”. Scientific Reports 7 (February). {Nature Publishing Group}. doi:10.1038/srep39898.
https://dx.doi.org/10.1038/srep39898
Cordier Céline, Boutimah Fatima, Bourdeloux Mathilde, Dupuy Florian, Met Elisabeth, Alberti Patrizia, Loll François, Chassaing Gérard, Burlina Fabienne, and Saison-Behmoaras Tula Ester. 2014. “Delivery of Antisense Peptide Nucleic Acids to Cells by Conjugation With Small Arginine-Rich Cell-Penetrating Peptide (R W)9”. PLoS ONE 9 (August). {Public Library of Science}: e104999. doi:10.1371/journal.pone.0104999.
https://dx.doi.org/10.1371/journal.pone.0104999
de Cian Anne, Grellier Philippe, Mouray Elisabeth, Depoix Delphine, Bertrand Hélène, Monchaud David, Teulade-Fichou Marie-Paule, Mergny Jean-Louis, and Alberti Patrizia. 2008. “Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds”. ChemBioChem 9 (November). {Wiley-VCH Verlag}: 2730-39. doi:10.1002/cbic.200800330.
https://dx.doi.org/10.1002/cbic.200800330
Tran Phong Lan Thao, Rieu Martin, Hodeib Samar, Joubert Alexandra, Ouellet Jimmy, Alberti Patrizia, Bugaut Anthony, Allemand Jean-François, Boulé Jean-Baptiste, and Croquette Vincent. 2021. “Folding and Persistence Times of Intramolecular G-Quadruplexes Transiently Embedded in a DNA Duplex”. Nucleic Acids Research, January. {Oxford University Press}. doi:10.1093/nar/gkab306.
https://dx.doi.org/10.1093/nar/gkab306
Valton Anne-Laure, Hassan-Zadeh Vahideh, Lema Ingrid, Boggetto Nicole, Alberti Patrizia, Saintomé Carole, Riou Jean-Francois, and Prioleau Marie-Noëlle. 2014. “G4 Motifs Affect Origin Positioning and Efficiency in Two Vertebrate Replicators”. EMBO Journal 33 (April). {EMBO Press}: 732-46. doi:10.1002/embj.201387506.
https://dx.doi.org/10.1002/embj.201387506
De Cian Anne, Guittat Lionel, Kaiser Markus, Saccà Barbara, Amrane Samir, Bourdoncle Anne, Alberti Patrizia, Teulade-Fichou Marie-Paule, Lacroix Laurent, and Mergny Jean-Louis. 2007. “Fluorescence-Based Melting Assays for Studying Quadruplex Ligands”. Methods 42 (June). {Elsevier}: 183-95. doi:10.1016/j.ymeth.2006.10.004.
https://dx.doi.org/10.1016/j.ymeth.2006.10.004
Bugaut Anthony, and Alberti Patrizia. 2015. “Understanding the Stability of DNA G-Quadruplex Units in Long Human Telomeric Strands”. Biochimie 113 (June). {Elsevier}: 125-33. doi:10.1016/j.biochi.2015.04.003.
https://dx.doi.org/10.1016/j.biochi.2015.04.003
Gurung Pratima, Gomes Ana Rita, Martins Rafael, Juranek Stefan, Alberti Patrizia, Mbang-Benet Diane-Ethna, Urbach S, et al. 2021. “PfGBP2 Is a Novel G-Quadruplex Binding Protein in Plasmodium Falciparum”. Cellular Microbiology 23 (April). {Wiley}: e13303. doi:10.1111/cmi.13303.
https://dx.doi.org/10.1111/cmi.13303
Saintomé C., Alberti Patrizia, Guinot N., Lejault P., Chatain J., Mailliet P., Riou Jean-Francois, and Bugaut A. 2018. “Binding Properties of Mono- and Dimeric Pyridine Dicarboxamide Ligands to Human Telomeric Higher-Order G-Quadruplex Structures”. Chemical Communications 54 (January). {Royal Society of Chemistry}: 1897-1900. doi:10.1039/c7cc07048a.
https://dx.doi.org/10.1039/c7cc07048a
Gazanion Elodie, Lacroix Laurent, Alberti Patrizia, Gurung Pratima, Wein Sharon, Cheng Mingpan, Mergny Jean-louis, Gomes Ana Rita, and Lopez‑rubio José‑juan. 2020. “Genome Wide Distribution of G-Quadruplexes and Their Impact on Gene Expression in Malaria Parasites”. PLoS Genetics 16 (July). {Public Library of Science}: e1008917. doi:10.1371/journal.pgen.1008917.
https://dx.doi.org/10.1371/journal.pgen.1008917
Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia, and Saintomé Carole. 2021. “Multiple HPOT1–TPP1 Cooperatively Unfold Contiguous Telomeric G-Quadruplexes Proceeding from 3’ Toward 5’, a Feature Due to a 3’-End Binding Preference and to Structuring of Telomeric DNA”. Nucleic Acids Research 49 (September). {Oxford University Press}: 10735-46. doi:10.1093/nar/gkab768.
https://dx.doi.org/10.1093/nar/gkab768
Chatain Jean, Blond Alain, Phan Anh Tuân, Saintomé Carole, and Alberti Patrizia. 2021. “GGGCTA Repeats Can Fold into Hairpins Poorly Unfolded by Replication Protein A: A Possible Origin of the Length-Dependent Instability of GGGCTA Variant Repeats in Human Telomeres”. Nucleic Acids Research, July. {Oxford University Press}. doi:10.1093/nar/gkab518.
https://dx.doi.org/10.1093/nar/gkab518
Safa Layal, Delagoutte Emmanuelle, Petruseva Irina, Alberti Patrizia, Lavrik Olga, Riou Jean-François, and Saintomé Carole. 2014. “Binding Polarity of RPA to Telomeric Sequences and Influence of G-Quadruplex Stability”. Biochimie 103 (August): 80-88. doi:10.1016/j.biochi.2014.04.006.
https://dx.doi.org/10.1016/j.biochi.2014.04.006
Wang Jiawei, Qiu Dehui, Zhou Jun, Mergny Jean-Louis, and Alberti Patrizia. 2026. “Guanine-Rich WGGGW Pentanucleotide Repeats, Including CANVAS AGGGA Repeats, Form a Variety of Non-Canonical Structures”. Nucleic Acids Research 54 (February). Oxford University Press. doi:10.1093/nar/gkag051.
https://dx.doi.org/10.1093/nar/gkag051
Saintomé Carole, Amrane Samir, Mergny Jean-louis, and Alberti Patrizia. 2016. “The Exception That Confirms the Rule: A Higher-Order Telomeric G-Quadruplex Structure More Stable in Sodium Than in Potassium”. Nucleic Acids Research 44 (January). {Oxford University Press}: 2926–2935. doi:10.1093/nar/gkw003.
https://dx.doi.org/10.1093/nar/gkw003
Lancrey Astrid, Safa Layal, Chatain Jean, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia, and Saintomé Carole. 2018. “The Binding Efficiency of RPA to Telomeric G-Strands Folded into Contiguous G-Quadruplexes Is Independent of the Number of G4 Units”. Biochimie 146 (March). {Elsevier}: 68-72. doi:10.1016/j.biochi.2017.11.017.
https://dx.doi.org/10.1016/j.biochi.2017.11.017
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