AASPE is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
Jean-Paul CONCORDET,
List of publications
, October 2021 — Recent Progress in Genome Editing for Gene Therapy Applications: The French Perspective. Human Gene Therapy. Vol. 32, 19-20, dir. Mary Ann Liebert, p. 1059-1075.
, December 2021 — « Tagging Proteins with Fluorescent Reporters Using the CRISPR/Cas9 System and Double-Stranded DNA Donors » in Multiprotein Complexes. P. 39-57.
, February 2021 — Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish. eLife. Vol. 10, dir. eLife Sciences Publication.
, July 2020 — Characterization of post-edited cells modified in the TFAM gene by CRISPR/Cas9 technology in the bovine model. PLoS ONE. Vol. 15, n° 7, dir. Public Library of Science, e0235856.
, January 2020 — Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion. Cell Reports. Vol. 30, n° 2, dir. Elsevier Inc, 583-597.e6.
, February 2020 — Expression analysis data of BCL11A and \gamma-globin genes in KU812 and KG-1 cell lines after CRISPR/Cas9-mediated BCL11A enhancer deletion. Data in Brief. Vol. 28, dir. Elsevier, p. 104974.
, July 2020 — Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins. Nature Communications. Vol. 11, n° 1, dir. Nature Publishing Group, p. 3778.
, February 2020 — Editing a y-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype. Science Advances. Vol. 6, n° 7, dir. American Association for the Advancement of Science (AAAS), eaay9392.
, March 2019 — Edition of TFAM gene by CRISPR/Cas9 technology in bovine model. PLoS ONE. Vol. 14, n° 3, dir. Public Library of Science, e0213376.
, November 2019 — Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9. Animal Model Exp Med / Animal models and experimental medicine. Vol. 2, n° 4, dir. [Hoboken, New Jersey] : John Wiley \\& Sons, Inc., [2018]-, p. 297-311.
, 2019 — Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells. PLoS Genetics. Vol. 15, n° 10, dir. Public Library of Science, e1008355.
, July 2019 — Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease. European Journal of Pharmacology. Vol. 854, dir. Elsevier, p. 398-405.
, August 2019 — Identification of the master sex determining gene in Northern pike (Esox lucius) reveals restricted sex chromosome differentiation. PLoS Genetics. Vol. 15, n° 8, dir. Public Library of Science, e1008013.
, December 2019 — Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. Nature Communications. Vol. 10, n° 1, dir. Nature Publishing Group, p. 1288.
, 2018 — Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models. Transplantation. Vol. 102, n° 8, dir. Lippincott, Williams \\& Wilkins, p. 1271-1278.
, December 2018 — High doses of CRISPR/Cas9 ribonucleoprotein efficiently induce gene knockout with low mosaicism in the hydrozoan Clytia hemisphaerica through microhomology-mediated deletion. Scientific Reports. Vol. 8, n° 1, dir. Nature Publishing Group.
, August 2018 — Cooperation, cis-interactions, versatility and evolutionary plasticity of multiple cis-acting elements underlie krox20 hindbrain regulation. PLoS Genetics. Vol. 14, n° 8, dir. Public Library of Science, e1007581.
, November 2017 — Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation. Scientific Reports. Vol. 7, n° 1, dir. Nature Publishing Group, p. 16554.
, April 2017 — Neu5Gc and \alpha1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs. Diabetes. Vol. 66, n° 4, dir. American Diabetes Association, 987-993..
, July 2016 — Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR.. Genome Biology. Vol. 17, n° 1, dir. BioMed Central, p. 148.