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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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    • GE2R _ Genome Editing, DNA double-strand break Repair and cellular Responses
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Remy Séverine, Tesson Laurent, Ménoret Séverine, Usal Claire, De Cian Anne, Thepenier Virginie, Thinard Reynald, Baron Daniel, Charpentier Marine, Renaud Jean-Baptiste, Buelow Roland, Cost Gregory J., Giovannangeli Carine, Fraichard Alexandre, Concordet Jean-Paul et al., August 2014 — Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases. Genome Research vol. 24, n° 8, dir. {Cold Spring Harbor Laboratory Press} p. 1371-1383
https://dx.doi.org/10.1101/gr.171538.113
Ménoret Séverine, Tesson Laurent, Rémy Severine, Usal Claire, Thépenier Virginie, Thinard Reynald, Ouisse Laure-Hélène, De Cian Anne, Giovannangeli Carine, Concordet Jean-Paul & Anegon Ignacio, August 2014 — Gene targeting in rats using transcription activator-like effector nucleases. Methods vol. 69, n° 1, dir. {Elsevier} p. 102-107
https://dx.doi.org/10.1016/j.ymeth.2014.02.027
Momose Tsuyoshi R, de Cian Anne, Shiba Kogiku, Inaba Kazuo, Giovannangeli Carine & Concordet Jean-Paul, December 2018 — High doses of CRISPR/Cas9 ribonucleoprotein efficiently induce gene knockout with low mosaicism in the hydrozoan Clytia hemisphaerica through microhomology-mediated deletion. Scientific Reports vol. 8, n° 1, dir. {Nature Publishing Group}
https://dx.doi.org/10.1038/s41598-018-30188-0
Weber Leslie, Frati Giacomo, Felix Tristan, Hardouin Giulia, Casini Antonio, Wollenschlaeger Clara, Meneghini Vasco, Masson Cecile, de Cian Anne, Chalumeau Anne, Mavilio Fulvio, Amendola Mario, Andre-Schmutz Isabelle, Cereseto Anna, El Nemer Wassim et al., February 2020 — Editing a \gamma-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype. Science Advances vol. 6, n° 7, dir. {American Association for the Advancement of Science (AAAS)} eaay9392
https://dx.doi.org/10.1126/sciadv.aay9392
Ménoret Séverine, de Cian Anne, Tesson Laurent, Remy Séverine, Usal Claire, Boulé Jean-Baptiste, Boix Charlotte, Fontanière Sandra, Crénéguy Alison, Nguyen Tuan H., Brusselle Lucas, Thinard Reynald, Gauguier Dominique, Concordet Jean-Paul, Cherifi Yacine et al., October 2015 — Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins. Scientific Reports vol. 5, , dir. {Nature Publishing Group} p. 14410
https://dx.doi.org/10.1038/srep14410
de Cian Anne, Grellier Philippe, Mouray Elisabeth, Depoix Delphine, Bertrand Hélène, Monchaud David, Teulade-Fichou Marie-Paule, Mergny Jean-Louis & Alberti Patrizia, November 2008 — Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds. ChemBioChem vol. 9, n° 16, dir. {Wiley-VCH Verlag} p. 2730-2739
https://dx.doi.org/10.1002/cbic.200800330
Bertrand Hélène, Monchaud David, de Cian Anne, Guillot Régis, Mergny Jean-Louis & Teulade-Fichou Marie-Paule, 2007 — The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes. Organic & Biomolecular Chemistry vol. 5, n° 16, dir. {Royal Society of Chemistry} p. 2555
https://dx.doi.org/10.1039/B708635K
de Cian Anne, Delemos Elsa, Mergny Jean-Louis, Teulade-Fichou Marie-Paule & Monchaud David, February 2007 — Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds. Journal of the American Chemical Society vol. 129, n° 7, dir. {American Chemical Society} p. 1856-1857
https://dx.doi.org/10.1021/ja067352b
Remy Séverine, Chenouard Vanessa, Tesson Laurent, Usal Claire, Ménoret Séverine, Brusselle Lucas, Heslan Jean-Marie, Nguyen Tuan Huan, Bellien Jeremy, Merot Jean, De Cian Anne, Giovannangeli Carine, Concordet Jean-Paul & Anegon Ignacio, November 2017 — Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation. Scientific Reports vol. 7, n° 1, dir. {Nature Publishing Group} p. 16554
https://dx.doi.org/10.1038/s41598-017-16328-y
Tesson Laurent, Remy Severine, Ménoret Séverine, Usal Claire, Thinard Reynald, Savignard Chloé, de Cian Anne, Giovannangeli Carine, Concordet Jean-Paul & Anegon Ignacio, 2016 — « Genome Editing in Rats Using TALE Nucleases » in TALENs. Methods in Molecular Biology.. , , p. 245-259
https://dx.doi.org/10.1007/978-1-4939-2932-0_18
Larcher Thibaut, Lafoux Aude, Tesson Laurent, Remy Severine, Thepenier Virginie, François Virginie, Le Guiner Caroline, Goubin Hélicia, Dutilleul Maeva, Guigand Lydie, Toumaniantz Gilles, de Cian Anne, Boix Charlotte, Renaud Jean-Baptiste, Cherel Yan et al., 2014 — Characterization of Dystrophin Deficient Rats: A New Model for Duchenne Muscular Dystrophy. PLoS ONE vol. 9, n° 10, dir. {Public Library of Science} 13 p.
https://dx.doi.org/10.1371/journal.pone.0110371
De Cian Anne, Cristofari G., Reichenbach P., De Lemos E., Monchaud David, Teulade-Fichou Marie-Paule, Shin-Ya K., Lacroix L., Lingner J. & Mergny Jean-Louis, October 2007 — Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.. Proceedings of the National Academy of Sciences of the United States of America vol. 104, n° 44, dir. {National Academy of Sciences} p. 17347-52
https://dx.doi.org/10.1073/pnas.0707365104
De Cian Anne, Guittat Lionel, Kaiser Markus, Saccà Barbara, Amrane Samir, Bourdoncle Anne, Alberti Patrizia, Teulade-Fichou Marie-Paule, Lacroix Laurent & Mergny Jean-Louis, June 2007 — Fluorescence-based melting assays for studying quadruplex ligands.. Methods vol. 42, n° 2, dir. {Elsevier} p. 183-95
https://dx.doi.org/10.1016/j.ymeth.2006.10.004
Charpentier M., Khedher A. H y, Menoret S., Brion A., Lamribet K., Dardillac E., Boix C., Perrouault L., Tesson L., Geny S., de Cian A., Itier J M, Anegon I., Lopez B., Giovannangeli C. et al., 2018 — CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair. Nature Communications vol. 9, n° 1, dir. {Nature Publishing Group}
https://dx.doi.org/10.1038/s41467-018-03475-7
Torbey Patrick, Thierion Elodie, Collombet Samuel, de Cian Anne, Desmarquet-Trin-Dinh Carole, Dura Mathilde, Concordet Jean-Paul, Charnay Patrick & Gilardi-Hebenstreit Pascale, August 2018 — Cooperation, cis-interactions, versatility and evolutionary plasticity of multiple cis-acting elements underlie krox20 hindbrain regulation. PLoS Genetics vol. 14, n° 8, dir. {Public Library of Science} e1007581
https://dx.doi.org/10.1371/journal.pgen.1007581
de Cian Anne, Praly Elise, Ding Fangyuan, Singh Vijender, Lavelle Christophe, Le Cam Eric, Croquette Vincent, Pietrement Olivier & Bensimon David, February 2012 — ATP-Independent Cooperative Binding of Yeast Isw1a to Bare and Nucleosomal DNA. PLoS ONE vol. 7, n° 2, dir. {Public Library of Science} e31845
https://dx.doi.org/10.1371/journal.pone.0031845
Bastin-Héline Lucie, de Fouchier Arthur A., Cao Song, Koutroumpa Fotini A., Caballero-Vidal Gabriela, Robakiewicz Stefania, Monsempes Christelle, Franç Marie-Christine, Ribeyre Tatiana, Maria Annick, Chertemps Thomas, de Cian Anne, Ill William B Walker, Wang Guirong, Jacquin-Joly Emmanuelle V et al., December 2019 — A novel lineage of candidate pheromone receptors for sex communication in moths. eLife vol. 8, , dir. {eLife Sciences Publication}
https://dx.doi.org/10.7554/eLife.49826
Anoud M., Delagoutte Emmanuelle, Helleu Quentin, Brion A., Duvernois-Berthet Evelyne, As M., Marques X., Lamribet K., Senamaud C., Jourdren L., Adrait A., Heinrich S., Toutirais G., Hamlaoui S., Gropplero G. et al., January 2024 — Comparative transcriptomics reveal a novel tardigrade specific DNA binding protein induced in response to ionizing radiation. eLife , ,
https://dx.doi.org/10.7554/eLife.92621.1
Babin Loélia, Darchen Alice, Robert Elie, Aid Zakia, Borry Rosalie, Soudais Claire, Piganeau Marion, de Cian Anne, Giovannangeli Carine, Bawa Olivia, Rigaud Charlotte, Scoazec Jean-Yves, Couronné Lucile, Veleanu Layla, Cieslak Agata et al., December 2022 — De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells. Molecular Cancer vol. 21, n° 1, dir. {BioMed Central} p. 65
https://dx.doi.org/10.1186/s12943-022-01520-0
Gaillard Anne-Laure, Mohamad Teddy, Quan Feng B, de Cian Anne, Mosimann Christian, Tostivint Hervé & Pézeron Guillaume, January 2023 — Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology vol. 496, , p. 36-51 working paper or preprint
https://dx.doi.org/10.1101/2022.08.09.503396
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