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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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    • GE2R _ Genome Editing, DNA double-strand break Repair and cellular Responses
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Anoud Marwan, Delagoutte Emmanuelle, Helleu Quentin, Brion Alice, Duvernois-Berthet Evelyne, As Marie, Marques Xavier, Lamribet Khadija, Senamaud-Beaufort Catherine, Jourdren Laurent & others, 2024 — Comparative transcriptomics reveal a novel tardigrade-specific DNA-binding protein induced in response to ionizing radiation. Elife vol. 13, , RP92621
Anoud M., Delagoutte Emmanuelle, Helleu Quentin, Brion A., Duvernois-Berthet Evelyne, As M., Marques X., Lamribet K., Senamaud C., Jourdren L., Adrait A., Heinrich S., Toutirais G., Hamlaoui S., Gropplero G. et al., January 2024 — Comparative transcriptomics reveal a novel tardigrade specific DNA binding protein induced in response to ionizing radiation. eLife , ,
https://dx.doi.org/10.7554/eLife.92621.1
Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, September 2021 — Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3’ toward 5’, a feature due to a 3’-end binding preference and to structuring of telomeric DNA. Nucleic Acids Research vol. 49, , dir. {Oxford University Press} p. 10735-10746
https://dx.doi.org/10.1093/nar/gkab768
Rouis Oumayma, Broussard Cedric, Guillonneau Francois, Boulé Jean-Baptiste & Delagoutte Emmanuelle, January 2020 — Identification of hemicatenane-specific binding proteins by fractionation of Hela nuclei extracts. Biochemical Journal vol. 477, n° 2, dir. {Portland Press} p. 509-524
https://dx.doi.org/10.1042/BCJ20190855
Saintomé Carole & Delagoutte Emmanuelle, August 2018 — Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins. PLoS ONE vol. 13, n° 8, dir. {Public Library of Science} e0202138
https://dx.doi.org/10.1371/journal.pone.0202138
Lancrey Astrid, Safa Layal, Chatain Jean, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, March 2018 — The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimie vol. 146, , dir. {Elsevier} p. 68-72
https://dx.doi.org/10.1016/j.biochi.2017.11.017
Solé Anna, Delagoutte Emmanuelle, Ciudad Carlos, Noé Véronique & Alberti Patrizia, March 2017 — Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes. Scientific Reports vol. 7, n° 1, dir. {Nature Publishing Group}
https://dx.doi.org/10.1038/srep39898
Safa Layal, Gueddouda Nassima Meriem, Thiébaut Frédéric, Delagoutte Emmanuelle, Petruseva Irina, Lavrik Olga, Mendoza Oscar, Bourdoncle Anne, Alberti Patrizia, Riou Jean-François & Saintomé Carole, 2016 — 5’ to 3’ Unfolding Directionality of DNA Secondary Structures by Replication Protein A. Journal of Biological Chemistry vol. 291, n° 40, dir. {American Society for Biochemistry and Molecular Biology} p. 21246-21256
https://dx.doi.org/10.1074/jbc.M115.709667
Millet Armêl, Strauss Francois & Delagoutte Emmanuelle, October 2015 — Use of double-stranded DNA mini-circles to characterize the covalent topoisomerase-DNA complex. Scientific Reports vol. 5, n° 1, dir. {Nature Publishing Group}
https://dx.doi.org/10.1038/srep13154
Audry Julien, Maestroni Laetitia, Delagoutte Emmanuelle, Gauthier Tiphaine, Nakamura Toru, Gachet Yannick, Saintomé Carole, Geli Vincent & Coulon Stephane, 2015 — RPA prevents G-rich structure formation at lagging- strand telomeres to allow maintenance of chromosome ends. EMBO Journal vol. 34, , dir. {EMBO Press} p. 1942-1958
https://dx.doi.org/10.15252/embj.201490773
Safa Layal, Delagoutte Emmanuelle, Petruseva Irina, Alberti Patrizia, Lavrik Olga, Riou Jean-François & Saintomé Carole, August 2014 — Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability. Biochimie vol. 103, , p. 80-88
https://dx.doi.org/10.1016/j.biochi.2014.04.006
Delagoutte Emmanuelle & Baldacci Giuseppe, 2011 — 5’CAG and 5’CTG Repeats Create Differential Impediment to the Progression of a Minimal Reconstituted T4 Replisome Depending on the Concentration of dNTPs.. Mol Biol Int vol. 2011, , p. 213824
https://dx.doi.org/10.4061/2011/213824
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  • Patrizia ALBERTI
  • Jean-Baptiste BOULÉ
  • Alice BRION
  • Jean-Paul CONCORDET
  • Anne DE CIAN
  • Evelyne DUVERNOIS
  • Carine GIOVANNANGELI
  • Quentin HELLEU
  • Khadija LAMRIBET
  • Xavier MARQUES
  • Loïc PONGER
  • Carole SAINTOMÉ
  • (-) Emmanuelle DELAGOUTTE

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