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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Anoud M., Delagoutte Emmanuelle, Helleu Quentin, Brion A., Duvernois-Berthet Evelyne, As M., Marques X., et al. 2024. “Comparative Transcriptomics Reveal a Novel Tardigrade Specific DNA Binding Protein Induced in Response to Ionizing Radiation”. ELife, January. eLife Sciences Publication. doi:10.7554/eLife.92621.1.
https://dx.doi.org/10.7554/eLife.92621.1
Babin Loélia, Darchen Alice, Robert Elie, Aid Zakia, Borry Rosalie, Soudais Claire, Piganeau Marion, et al. 2022. “De Novo Generation of the NPM-ALK Fusion Recapitulates the Pleiotropic Phenotypes of ALK+ ALCL Pathogenesis and Reveals the ROR2 Receptor As Target for Tumor Cells”. Molecular Cancer 21 (December). BioMed Central; {BioMed Central}: 65. doi:10.1186/s12943-022-01520-0.
https://dx.doi.org/10.1186/s12943-022-01520-0
Antoniou Panagiotis, Hardouin Giulia, Martinucci Pierre, Frati Giacomo, Felix Tristan, Chalumeau Anne, Fontana Letizia, et al. 2022. “Base-Editing-Mediated Dissection of a γ-Globin Cis-Regulatory Element for the Therapeutic Reactivation of Fetal Hemoglobin Expression”. Nature Communications 13 (November). Nature Publishing Group: 6618. doi:10.1038/s41467-022-34493-1.
https://dx.doi.org/10.1038/s41467-022-34493-1
Rosello Marion, Serafini Malo, Mignani Luca, Finazzi Dario, Giovannangeli Carine, Mione Marina C, Concordet Jean-Paul, and del Bene Filippo. 2022. “Disease Modeling by Efficient Genome Editing Using a Near PAM-Less Base Editor in Vivo”. Nature Communications 13 (June). Nature Publishing Group; {Nature Publishing Group}: 3435. doi:10.1038/s41467-022-31172-z.
https://dx.doi.org/10.1038/s41467-022-31172-z
Amendola Mario, Bedel Aurélie, Buj-Bello Ana, Carrara Mathieu, Concordet Jean-Paul, Frati Giacomo, Gilot David, et al. 2021. “Recent Progress in Genome Editing for Gene Therapy Applications: The French Perspective”. Human Gene Therapy 32 (October). {Mary Ann Liebert}: 1059-75. doi:10.1089/hum.2021.191.
https://dx.doi.org/10.1089/hum.2021.191
Sole Anna, Grossetête Sandrine, Heintzé Maxime, Babin Loelia, Zaïdi Sakina, Revy Patrick, Renouf Benjamin, et al. 2021. “Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells”. Cancer Research 81 (October). {American Association for Cancer Research}: 4994-5006. doi:10.1158/0008-5472.CAN-20-3837.
https://dx.doi.org/10.1158/0008-5472.CAN-20-3837
Weber Leslie, Frati Giacomo, Felix Tristan, Hardouin Giulia, Casini Antonio, Wollenschlaeger Clara, Meneghini Vasco, et al. 2020. “Editing a \gamma-Globin Repressor Binding Site Restores Fetal Hemoglobin Synthesis and Corrects the Sickle Cell Disease Phenotype”. Science Advances 6 (February). {American Association for the Advancement of Science (AAAS)}: eaay9392. doi:10.1126/sciadv.aay9392.
https://dx.doi.org/10.1126/sciadv.aay9392
Garcin Edwige B, Gon Stéphanie, Sullivan Meghan, Brunette Gregory J, Cian Anne De, Concordet Jean-Paul, Giovannangeli Carine, et al. 2019. “Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells”. PLoS Genetics 15 (January). {Public Library of Science}: e1008355. doi:10.1371/journal.pgen.1008355.
https://dx.doi.org/10.1371/journal.pgen.1008355
Momose Tsuyoshi R, de Cian Anne, Shiba Kogiku, Inaba Kazuo, Giovannangeli Carine, and Concordet Jean-Paul. 2018. “High Doses of CRISPR Cas9 Ribonucleoprotein Efficiently Induce Gene Knockout With Low Mosaicism in the Hydrozoan Clytia Hemisphaerica through Microhomology-Mediated Deletion”. Scientific Reports 8 (December). {Nature Publishing Group}. doi:10.1038/s41598-018-30188-0.
https://dx.doi.org/10.1038/s41598-018-30188-0
Mannioui Abdelkrim, Vauzanges Quentin, Fini Jean Baptiste, Henriet Esther, Sekizar Somya, Azoyan Loris, Thomas JeanLéon, et al. 2018. “The Xenopus Tadpole: An in Vivo Model to Screen Drugs Favoring Remyelination”. Multiple Sclerosis Journal 24 (July). {SAGE Publications}: 1421-32. doi:10.1177/1352458517721355.
https://dx.doi.org/10.1177/1352458517721355
Ménoret Séverine, Ouisse Laure-Hélène, Tesson L., Remy S., Usal Claire, Concordet J.-P., Giovannangeli C., et al. 2018. “Generation of Rag1 and Il2rg Immunodeficient Rats and Application to Humanization Studies”. https://www.hal.inserm.fr/inserm-02160389.
https://www.hal.inserm.fr/inserm-02160389
Menoret Séverine, Ouisse Laure-Hélène, Tesson Laurent, Delbos Frédéric, Garnier Delphine, Remy Severine, Usal Claire, et al. 2018. “Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models”. Transplantation 102 (January). {Lippincott, Williams \& Wilkins}: 1271-78. doi:10.1097/TP.0000000000002251.
https://dx.doi.org/10.1097/TP.0000000000002251
Babin Loelia, Piganeau Marion, Renouf Benjamin, Lamribet Khadija, Thirant Cécile, Deriano Ludovic, Mercher Thomas, Giovannangeli Carine, and Brunet Erika. 2018. “Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells”. IScience 5 (January). {Elsevier}: 19-29. doi:10.1016/j.isci.2018.06.007.
https://dx.doi.org/10.1016/j.isci.2018.06.007
Charpentier M., Khedher A. H y, Menoret S., Brion A., Lamribet K., Dardillac E., Boix C., et al. 2018. “CtIP Fusion to Cas9 Enhances Transgene Integration by Homology-Dependent Repair”. Nature Communications 9 (January). {Nature Publishing Group}. doi:10.1038/s41467-018-03475-7.
https://dx.doi.org/10.1038/s41467-018-03475-7
Remy Séverine, Chenouard Vanessa, Tesson Laurent, Usal Claire, Ménoret Séverine, Brusselle Lucas, Heslan Jean-Marie, et al. 2017. “Generation of Gene-Edited Rats by Delivery of CRISPR Cas9 Protein and Donor DNA into Intact Zygotes Using Electroporation”. Scientific Reports 7 (November). {Nature Publishing Group}: 16554. doi:10.1038/s41598-017-16328-y.
https://dx.doi.org/10.1038/s41598-017-16328-y
Duroux-Richard Isabelle, Giovannangeli Carine, and Apparailly Florence. 2017. “CRISPR-Cas9: A Revolution in Genome Editing in Rheumatic Diseases”. Joint Bone Spine 84 (January). {Elsevier Masson}: 1-4. doi:10.1016/j.jbspin.2016.09.012.
https://dx.doi.org/10.1016/j.jbspin.2016.09.012
Berthelot Vivien, Mouta-Cardoso Gildas, Hégarat Nadia, Guillonneau François, François Jean-Christophe, Giovannangeli Carine, Praseuth Danièle, and Rusconi Filippo. 2016. “The Human DNA Ends Proteome Uncovers an Unexpected Entanglement of Functional Pathways”. Nucleic Acids Research 44 (June). {Oxford University Press}: 4721-33. doi:10.1093/nar/gkw121.
https://dx.doi.org/10.1093/nar/gkw121
Renaud Jean-Baptiste, Boix Charlotte, Charpentier Marine, deCian Anne, Cochennec Julien, Duvernois-Berthet Evelyne, Perrouault Loïc, et al. 2016. “Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides With TALEN and CRISPR-Cas9 Nucleases”. Cell Reports 14 (March). {Elsevier Inc}: 2263-72. doi:10.1016/j.celrep.2016.02.018.
https://dx.doi.org/10.1016/j.celrep.2016.02.018
Tesson Laurent, Remy Severine, Ménoret Séverine, Usal Claire, Thinard Reynald, Savignard Chloé, de Cian Anne, Giovannangeli Carine, Concordet Jean-Paul, and Anegon Ignacio. 2016. “Genome Editing in Rats Using TALE Nucleases”. In TALENs. Methods in Molecular Biology, 245-59. doi:10.1007/978-1-4939-2932-0_18.
https://dx.doi.org/10.1007/978-1-4939-2932-0_18
Blasimme Alessandro, Anegon Ignacio, Concordet Jean-Paul, deVos John, Dubart-Kupperschmitt Anne, Fellous Marc, Fouchet Pierre, et al. 2015. “Genome Editing and Dialogic Responsibility: ‘What’s in a Name?’”. American Journal of Bioethics 15 (December). {Taylor \& Francis (Routledge)}: 54-57. doi:10.1080/15265161.2015.1103811.
https://dx.doi.org/10.1080/15265161.2015.1103811
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