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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Mozziconacci Julien & Laine Élodie, April 2026 — Comment l’IA apprend le langage secret de l’ADN, et ce que la recherche y gagne. , ,
https://dx.doi.org/10.64628/AAK.x45jqwerp
HAL ID
hal-05735955
Laine Élodie & Mozziconacci Julien, March 2026 — AlphaGenome, une nouvelle avancée en intelligence artificielle pour explorer les effets des mutations génétiques. , ,
https://dx.doi.org/10.64628/AAK.vc7uw5w7p
HAL ID
hal-05735945
Ganesh Gautham, Fiche Jean-Bernard, Nöllmann Marcelo & Mozziconacci Julien, November 2025 — Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes. , , working paper or preprint
https://dx.doi.org/10.1101/2025.06.20.660702
HAL ID
hal-05358669
Christophe Maxime, Altamirano-Pacheco Luis, Navarro Pablo & Mozziconacci Julien, July 2025 — Interpretable deep learning reveals sequence determinants of nucleosome positioning in mouse genome. , , Poster
https://hal.science/hal-05285046
HAL ID
hal-05285046
Meneu Léa, Chapard Christophe, Serizay Jacques, Westbrook Alex, Routhier Etienne, Ruault Myriam, Perrot Manon, Minakakis Alexandros, Girard Fabien, Bignaud Amaury, Even Antoine, Gourgues Géraldine, Libri Domenico, Lartigue Carole, Piazza Aurèle et al., March 2025 — Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus. Science vol. 387, n° 6734, eadm9466
https://dx.doi.org/10.1126/science.adm9466
HAL ID
hal-04937691
Gil José, Navarrete Emily, Rosin L.F., Chowdhury Neil, Abraham Sameer, Cornilleau Gaétan, Lei E.P., Mozziconacci Julien, Mirny L.A., Muller Héloïse & Drinnenberg I.A., July 2024 — Unique territorial and compartmental organization of chromosomes in the holocentric silkmoth. , , working paper or preprint
https://dx.doi.org/10.1101/2023.09.14.557757
HAL ID
hal-04658951
Bignaud Amaury, Cockram Charlotte, Borde Céline, Groseille Justine, Allemand Eric, Thierry Agnès, Marbouty Martial, Mozziconacci Julien, Espéli Olivier & Koszul Romain, January 2024 — Transcription-induced domains form the elementary constraining building blocks of bacterial chromosomes. Nature Structural and Molecular Biology , ,
https://dx.doi.org/10.1038/s41594-023-01178-2
Luo Jingchuan, Vale-Silva Luis A, Raghavan Adhithi R, Mercy Guillaume, Heldrich Jonna, Sun Xiaoji, Li Mingyu Kenneth, Zhang Weimin, Agmon Neta, Yang Kun, Cai Jitong, Stracquadanio Giovanni, Thierry Agnès, Zhao Yu, Coelho Camila et al., November 2023 — Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function. Cell Genomics vol. 3, n° 11, p. 100439
https://dx.doi.org/10.1016/j.xgen.2023.100439
Westbrook Alex, Routhier Etienne, Mozziconacci Julien, Koszul Romain & Boulé Jean-Baptiste, November 2023 — Nucleosome positioning in yeast: from prediction to synthetic design. , , Poster
https://mnhn.hal.science/mnhn-04344672
Carron Léoplod, Concia Lorenzo, Grob Stefan, Barneche Fredy, Carbone Alessandra & Mozziconacci Julien, November 2023 — A layer cake model for plant and metazoan chromatin. , , working paper or preprint
https://dx.doi.org/10.1101/2023.02.24.529851
Westbrook Alex, Routhier Etienne, Mozziconacci Julien, Koszul Romain & Boulé Jean-Baptiste, November 2023 — Nucleosome positioning in yeast: from prediction to synthetic design. , , Poster
https://mnhn.hal.science/mnhn-04344672
HAL ID
mnhn-04344672
Routhier Ethienne, Joubert Alexandra, Westbrook Alex, Pierre Edgar, Lancrey Astrid, Cariou Marie, Boulé Jean-Baptiste & Mozziconacci Julien, 2023 — In silico design of DNA sequences for in vivo nucleosome positioning. Nucleic Acids Research vol. 52, n° 12,
https://dx.doi.org/10.1093/nar/gkae468
Lazar-Stefanita Luciana, Luo Jingchuan, Montagne Remi, Thierry Agnes, Sun Xiaoji, Mercy Guillaume, Mozziconacci Julien, Koszul Romain & Boeke Jef D, August 2022 — Karyotype engineering reveals spatio-temporal control of replication firing and gene contacts. Cell Genomics vol. 2, n° 8, p. 100163
https://dx.doi.org/10.1016/j.xgen.2022.100163
Routhier Etienne & Mozziconacci Julien, June 2022 — Genomics enters the deep learning era. PeerJ vol. 10, , e13613
https://dx.doi.org/10.7717/peerj.13613
Lancrey Astrid, Joubert Alexandra, Duvernois-Berthet Evelyne, Routhier Etienne, Raj Saurabh, Thierry Agnès, Sigarteu Marta, Ponger Loic, Croquette Vincent, Mozziconacci Julien & Boulé Jean-Baptiste, April 2022 — Nucleosome positioning on large tandem DNA repeats of the ’601’ sequence engineered in Saccharomyces cerevisiae. Journal of Molecular Biology , ,
https://dx.doi.org/10.1016/j.jmb.2022.167497
Jablonski Kim Philipp, Carron Leopold, Mozziconacci Julien, Forné Thierry, Hütt Marc-Thorsten & Lesne Annick, January 2022 — Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study. Human Genomics vol. 16, n° 1, dir. {BioMed Central} p. 2
https://dx.doi.org/10.1186/s40246-022-00375-2
Carron Leopold, Morlot Jean-Baptiste, Lesne Annick & Mozziconacci Julien, 2022 — The 3D organization of chromatin colors in mammalian nuclei. Methods in Molecular Biology vol. 2301, , p. 317-336
https://dx.doi.org/10.1007/978-1-0716-1390-0\_17
Haschka Thomas, Baptiste Morlot Jean, Carron Leopold & Mozziconacci Julien, July 2021 — Improving distance measures between genomic tracks with mutual proximity. Briefings in Bioinformatics , , dir. {Oxford University Press (OUP)}
https://dx.doi.org/10.1093/bib/bbab266
Decombe Sheldon, Loll François, Caccianini Laura, Affannoukoué Kévin, Izeddin Ignacio, Mozziconacci Julien, Escudé Christophe & Lopes Judith, July 2021 — Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability. Epigenetics & Chromatin vol. 14, n° 1, dir. {BioMed Central}
https://dx.doi.org/10.1186/s13072-021-00410-x
Decombe Sheldon, Loll François, Caccianini Laura, Affannoukoué Kévin, Izeddin Ignacio, Mozziconacci Julien, Escudé Christophe & Lopes Judith, July 2021 — Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability. Epigenetics & Chromatin vol. 14, n° 1,
https://dx.doi.org/10.1186/s13072-021-00410-x
HAL ID
hal-03336457
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