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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Amendola Mario, Bedel Aurélie, Buj-Bello Ana, Carrara Mathieu, Concordet Jean-Paul, Frati Giacomo, Gilot David, Giovannangeli Carine, Gutierrez-Guerrero Alejandra, Laurent Marine, Miccio Annarita, Moreau-Gaudry François, Sourd Célia, Valton Julien & Verhoeyen Els, October 2021 — Recent Progress in Genome Editing for Gene Therapy Applications: The French Perspective. Human Gene Therapy vol. 32, 19-20, dir. {Mary Ann Liebert} p. 1059-1075
https://dx.doi.org/10.1089/hum.2021.191
Pavani Giulia, Fabiano Anna, Laurent Marine, Amor Fatima, Cantelli Erika, Chalumeau Anne, Maule Giulia, Tachtsidi Alexandra, Concordet Jean-Paul, Cereseto Anna, Mavilio Fulvio, Ferrari Giuliana, Miccio Annarita & Amendola Mario, March 2021 — Correction of \beta-thalassemia by CRISPR/Cas9 editing of the \alpha-globin locus in human hematopoietic stem cells. Blood Advances vol. 5, n° 5, dir. {The American Society of Hematology} p. 1137-1153
https://dx.doi.org/10.1182/bloodadvances.2020001996
Subecz Chloé, Sun Jian-Sheng & Roger Lauréline, February 2021 — Effect of DNA repair inhibitor AsiDNA on the incidence of telomere fusion in crisis. Human Molecular Genetics vol. 30, 3-4, dir. {Oxford University Press (OUP)} p. 172-181
https://dx.doi.org/10.1093/hmg/ddab008
Rosello Marion, Vougny Juliette, Czarny François, Mione Marina, Concordet Jean-Paul, Albadri Shahad & del Bene Filippo, February 2021 — Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish. eLife vol. 10, , dir. {eLife Sciences Publication}
https://dx.doi.org/10.7554/elife.65552
Geny Sylvain, Pichard Simon, Poterszman Arnaud & Concordet Jean-Paul, 2021 — Gene Tagging with the CRISPR-Cas9 System to Facilitate Macromolecular Complex Purification. Methods in molecular biology (Clifton, N.J.) vol. 2305, , p. 153-174
https://dx.doi.org/10.1007/978-1-0716-1406-8_8
Ahmed Raya, Miners Kelly, Lahoz-Beneytez Julio, Jones Rhiannon, Roger Lauréline, Baboonian Christina, Zhang Yan, Wang Eddie C.Y., Hellerstein Marc, Mccune Joseph, Baird Duncan, Price David, Macallan Derek, Asquith Becca & Ladell Kristin, December 2020 — CD57+ Memory T Cells Proliferate In Vivo. Cell Reports vol. 33, n° 11, dir. {Elsevier Inc} p. 108501
https://dx.doi.org/10.1016/j.celrep.2020.108501
de Oliveira Vanessa Cristina, Gomes Mariano Junior Clésio, Belizário José Ernesto, Krieger José Eduardo, Fernandes Bressan Fabiana, Roballo Kelly Cristine Santos, Fantinato-Neto Paulo, Meirelles Flávio Vieira, Chiaratti Marcos Roberto, Concordet Jean-Paul & Ambrósio Carlos Eduardo, July 2020 — Characterization of post-edited cells modified in the TFAM gene by CRISPR/Cas9 technology in the bovine model. PLoS ONE vol. 15, n° 7, dir. {Public Library of Science} e0235856
https://dx.doi.org/10.1371/journal.pone.0235856
Pavani Giulia, Laurent Marine, Fabiano Anna, Cantelli Erika, Sakkal Aboud, Corre Guillaume, Lenting Peter J., Concordet Jean-Paul, Toueille Magali, Miccio Annarita & Amendola Mario, July 2020 — Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins. Nature Communications vol. 11, n° 1, dir. {Nature Publishing Group} p. 3778
https://dx.doi.org/10.1038/s41467-020-17552-3
Weber Leslie, Frati Giacomo, Felix Tristan, Hardouin Giulia, Casini Antonio, Wollenschlaeger Clara, Meneghini Vasco, Masson Cecile, de Cian Anne, Chalumeau Anne, Mavilio Fulvio, Amendola Mario, Andre-Schmutz Isabelle, Cereseto Anna, El Nemer Wassim et al., February 2020 — Editing a \gamma-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype. Science Advances vol. 6, n° 7, dir. {American Association for the Advancement of Science (AAAS)} eaay9392
https://dx.doi.org/10.1126/sciadv.aay9392
Khosravi Mohammad Ali, Abbasalipour Maryam, Concordet Jean-Paul, Berg Johannes Vom, Zeinali Sirous, Arashkia Arash, Buch Thorsten & Karimipoor Morteza, February 2020 — Expression analysis data of BCL11A and \gamma-globin genes in KU812 and KG-1 cell lines after CRISPR/Cas9-mediated BCL11A enhancer deletion. Data in Brief vol. 28, , dir. {Elsevier} p. 104974
https://dx.doi.org/10.1016/j.dib.2019.104974
Yan Zheng, Martin Simon H, Gotzek Dietrich, Arsenault Samuel V, Duchen Pablo, Helleu Quentin, Riba-Grognuz Oksana, Hunt Brendan G, Salamin Nicolas, Shoemaker DeWayne & others, February 2020 — Evolution of a supergene that regulates a trans-species social polymorphism. Nature Ecology & Evolution vol. 4, n° 2, dir. {Nature} p. 240-249
https://dx.doi.org/10.1038/s41559-019-1081-1
Joutsen Jenny, da Silva Alejandro Jose, Luoto Jens Christian, Budzynski Marek Andrzej, Nylund Anna Serafia, de Thonel Aurélie, Concordet Jean-Paul, Mezger Valérie, Sabéran-Djoneidi Délara, Henriksson Eva & Sistonen Lea, January 2020 — Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion. Cell Reports vol. 30, n° 2, dir. {Elsevier Inc} 583-597.e6
https://dx.doi.org/10.1016/j.celrep.2019.12.037
Sandoz Jérémy, Nagy Zita, Catez Philippe, Caliskan Gizem, Geny Sylvain, Renaud Jean-Baptiste, Concordet Jean-Paul, Poterszman Arnaud, Tora Làszlò, Egly Jean-Marc, Le May Nicolas & Coin Frédéric, December 2019 — Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. Nature Communications vol. 10, n° 1, dir. {Nature Publishing Group} p. 1288
https://dx.doi.org/10.1038/s41467-019-09270-2
Bastin-Héline Lucie, de Fouchier Arthur A., Cao Song, Koutroumpa Fotini A., Caballero-Vidal Gabriela, Robakiewicz Stefania, Monsempes Christelle, Franç Marie-Christine, Ribeyre Tatiana, Maria Annick, Chertemps Thomas, de Cian Anne, Ill William B Walker, Wang Guirong, Jacquin-Joly Emmanuelle V et al., December 2019 — A novel lineage of candidate pheromone receptors for sex communication in moths. eLife vol. 8, , dir. {eLife Sciences Publication}
https://dx.doi.org/10.7554/eLife.49826
Dreano Elise, Bacchetta Marc, Simonin Juliette, Galmiche Louise, Usal Claire, Slimani Lotfi, Sadoine Jérémy, Tesson Laurent, Anegon Ignacio, Concordet Jean-paul, Hatton Aurélie, Vignaud Lucile, Tondelier Danielle, Sermet-gaudelus Isabelle, Chanson Marc et al., November 2019 — Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9. Animal Model Exp Med / Animal models and experimental medicine. vol. 2, n° 4, dir. {[Hoboken, New Jersey] : John Wiley \& Sons, Inc., [2018]-} p. 297-311
https://dx.doi.org/10.1002/ame2.12091
Pan Qiaowei, Feron Romain, Yano Ayaka, Guyomard René, Jouanno Elodie, Vigouroux Estelle, Wen Ming, Busnel Jean-Mickaël, Bobe Julien, Concordet Jean-Paul, Parrinello Hugues, Journot Laurent, Klopp Christophe C., Lluch Jérôme, Roques Céline et al., August 2019 — Identification of the master sex determining gene in Northern pike (Esox lucius) reveals restricted sex chromosome differentiation. PLoS Genetics vol. 15, n° 8, dir. {Public Library of Science} e1008013
https://dx.doi.org/10.1371/journal.pgen.1008013
Khosravi Mohammad Ali, Abbasalipour Maryam, Concordet Jean-Paul, Berg Johannes Vom, Zeinali Sirous, Arashkia Arash, Azadmanesh Kayhan, Buch Thorsten & Karimipoor Morteza, July 2019 — Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease. European Journal of Pharmacology vol. 854, , dir. {Elsevier} p. 398-405
https://dx.doi.org/10.1016/j.ejphar.2019.04.042
Ben Ammar Rym, Piet Marie-Hélène, Brion Alice, Telahigue Khaoula, Werheni Rim, Rousseau Marthe, El Cafsi Mhamed & Gillet Pierre, June 2019 — Induction of Osteogenic MC3T3-E1 Cell Differentiation by Nacre and Flesh Lipids of Tunisian Pinctada radiata. Lipids vol. 54, n° 8, dir. {Springer Verlag} p. 433-444
https://dx.doi.org/10.1002/lipd.12141
de Oliveira Vanessa Cristina, Moreira Gabriel Sassarão Alves, Bressan Fabiana Fernandes, Gomes Mariano Junior Clésio, Roballo Kelly Cristine Santos, Charpentier Marine, Concordet Jean-Paul, Meirelles Flávio Vieira & Ambrósio Carlos Eduardo, March 2019 — Edition of TFAM gene by CRISPR/Cas9 technology in bovine model. PLoS ONE vol. 14, n° 3, dir. {Public Library of Science} e0213376
https://dx.doi.org/10.1371/journal.pone.0213376
Kuhn Emmanuelle, Lamribet Khadija, Viengchareun Say, LeMenuet Damien, Fève Bruno & Lombès Marc, February 2019 — UCP1 transrepression in Brown Fat in vivo and mineralocorticoid receptor anti-thermogenic effects. Annales d’Endocrinologie vol. 80, n° 1, dir. {Elsevier Masson} p. 1-9
https://dx.doi.org/10.1016/j.ando.2018.04.018
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