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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Tran Phong Lan Thao, Mergny Jean-Louis & Alberti Patrizia, April 2011 — Stability of telomeric G-quadruplexes. Nucleic Acids Research vol. 39, n° 8, dir. {Oxford University Press} p. 3282-3294
https://dx.doi.org/10.1093/nar/gkq1292
de Cian Anne, Grellier Philippe, Mouray Elisabeth, Depoix Delphine, Bertrand Hélène, Monchaud David, Teulade-Fichou Marie-Paule, Mergny Jean-Louis & Alberti Patrizia, November 2008 — Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds. ChemBioChem vol. 9, n° 16, dir. {Wiley-VCH Verlag} p. 2730-2739
https://dx.doi.org/10.1002/cbic.200800330
Ahowesso C., Piccolo E., Li X. M., Dulong S., Hossard V., La Sorda R., Filipski E., Tinari N., Delaunay F., Iacobelli S. & Lévi F., February 2010 — Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice.. Toxicology Letters vol. 192, n° 3, dir. {Elsevier} p. 395-401
https://dx.doi.org/10.1016/j.toxlet.2009.11.017
Champion Christine, Guianvarc’H Dominique, Sénamaud-Beaufort Catherine, Jurkowska Renata Z, Jeltsch Albert, Ponger Loïc, Arimondo Paola B & Guieysse-Peugeot Anne-Laure, 2010 — Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.. PLoS ONE vol. 5, n° 8, dir. {Public Library of Science} e12388
https://dx.doi.org/10.1371/journal.pone.0012388
Tran Phong Lan Thao, Rieu Martin, Hodeib Samar, Joubert Alexandra, Ouellet Jimmy, Alberti Patrizia, Bugaut Anthony, Allemand Jean-François, Boulé Jean-Baptiste & Croquette Vincent, 2021 — Folding and persistence times of intramolecular G-quadruplexes transiently embedded in a DNA duplex. Nucleic Acids Research , , dir. {Oxford University Press}
https://dx.doi.org/10.1093/nar/gkab306
Subecz Chloé, Sun Jian-Sheng & Roger Lauréline, February 2021 — Effect of DNA repair inhibitor AsiDNA on the incidence of telomere fusion in crisis. Human Molecular Genetics vol. 30, 3-4, dir. {Oxford University Press (OUP)} p. 172-181
https://dx.doi.org/10.1093/hmg/ddab008
Solé Anna, Delagoutte Emmanuelle, Ciudad Carlos, Noé Véronique & Alberti Patrizia, February 2017 — Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes. Scientific Reports vol. 7, n° 1, dir. {Nature Publishing Group}
https://dx.doi.org/10.1038/srep39898
Cordier Céline, Boutimah Fatima, Bourdeloux Mathilde, Dupuy Florian, Met Elisabeth, Alberti Patrizia, Loll François, Chassaing Gérard, Burlina Fabienne & Saison-Behmoaras Tula Ester, August 2014 — Delivery of Antisense Peptide Nucleic Acids to Cells by Conjugation with Small Arginine-Rich Cell-Penetrating Peptide (R/W)9. PLoS ONE vol. 9, n° 8, dir. {Public Library of Science} e104999
https://dx.doi.org/10.1371/journal.pone.0104999
Coquery Nicolas, Pannetier Nicolas, Farion Régine, Herbette Aurélie, Azurmendi Leire, Clarencon Didier, Bauge Stéphane, Josserand Véronique, Rome Claire, Coll Jean-Luc, Sun Jian-Sheng, Barbier Emmanuel L, Dutreix Marie & Rémy ChantalC., 2012 — Distribution and radiosensitizing effect of cholesterol-coupled Dbait molecule in rat model of glioblastoma.. PLoS ONE vol. 7, n° 7, dir. {Public Library of Science} e40567
https://dx.doi.org/10.1371/journal.pone.0040567
Audry Julien, Maestroni Laetitia, Delagoutte Emmanuelle, Gauthier Tiphaine, Nakamura Toru, Gachet Yannick, Saintomé Carole, Geli Vincent & Coulon Stephane, 2015 — RPA prevents G-rich structure formation at lagging- strand telomeres to allow maintenance of chromosome ends. EMBO Journal vol. 34, , dir. {EMBO Press} p. 1942-1958
https://dx.doi.org/10.15252/embj.201490773
Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, September 2021 — Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3’ toward 5’, a feature due to a 3’-end binding preference and to structuring of telomeric DNA. Nucleic Acids Research vol. 49, , dir. {Oxford University Press} p. 10735-10746
https://dx.doi.org/10.1093/nar/gkab768
Chatain Jean, Blond Alain, Phan Anh Tuân, Saintomé Carole & Alberti Patrizia, July 2021 — GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Research , , dir. {Oxford University Press}
https://dx.doi.org/10.1093/nar/gkab518
Dorleans Audrey, Gigant Benoît, Ravelli Raimond, Mailliet Patrick, Mikol Vincent & Knossow Marcel, August 2009 — Variations in the colchicine-binding domain provide insight into the structural switch of tubulin. Proceedings of the National Academy of Sciences of the United States of America vol. 106, n° 33, dir. {National Academy of Sciences} p. 13775-13779
https://dx.doi.org/10.1073/pnas.0904223106
Douarre Céline, Gomez Dennis, Morjani Hamid, Zahm Jean-Marie, O’Donohue Marie-Françoise, Eddabra Lahcen, Mailliet Patrick, Riou Jean-Francois & Trentesaux Chantal, April 2005 — Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence. Nucleic Acids Research vol. 33, n° 7, dir. {Oxford University Press} p. 2192-2203
https://dx.doi.org/10.1093/nar/gki514
De Cian Anne, Guittat Lionel, Kaiser Markus, Saccà Barbara, Amrane Samir, Bourdoncle Anne, Alberti Patrizia, Teulade-Fichou Marie-Paule, Lacroix Laurent & Mergny Jean-Louis, June 2007 — Fluorescence-based melting assays for studying quadruplex ligands.. Methods vol. 42, n° 2, dir. {Elsevier} p. 183-95
https://dx.doi.org/10.1016/j.ymeth.2006.10.004
Bugaut Anthony & Alberti Patrizia, June 2015 — Understanding the stability of DNA G-quadruplex units in long human telomeric strands. Biochimie vol. 113, , dir. {Elsevier} p. 125-133
https://dx.doi.org/10.1016/j.biochi.2015.04.003
Gurung Pratima, Gomes Ana Rita, Martins Rafael, Juranek Stefan, Alberti Patrizia, Mbang-Benet Diane-Ethna, Urbach S, Gazanion Elodie, Guitard Vincent, Paeschke Katrin & Lopez-Rubio José Juan, April 2021 — PfGBP2 is a novel G-quadruplex binding protein in Plasmodium falciparum. Cellular Microbiology vol. 23, n° 4, dir. {Wiley} e13303
https://dx.doi.org/10.1111/cmi.13303
Saintomé C., Alberti Patrizia, Guinot N., Lejault P., Chatain J., Mailliet P., Riou Jean-Francois & Bugaut A., 2018 — Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures. Chemical Communications vol. 54, n° 15, dir. {Royal Society of Chemistry} p. 1897-1900
https://dx.doi.org/10.1039/c7cc07048a
Gazanion Elodie, Lacroix Laurent, Alberti Patrizia, Gurung Pratima, Wein Sharon, Cheng Mingpan, Mergny Jean-louis, Gomes Ana Rita & Lopez‑rubio José‑juan, July 2020 — Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites. PLoS Genetics vol. 16, n° 7, dir. {Public Library of Science} e1008917
https://dx.doi.org/10.1371/journal.pgen.1008917
Krämer Andreas, Tjaden Amelie, Ndreshkjana Benardina, Tredup Claudia, Farin Henner, Knapp Stefan, Janin Yves & Müller Susanne, 2022 — IPP/CNRS-A017: A chemical probe for human dihydroorotate dehydrogenase (hDHODH). Current Research in Chemical Biology vol. 2, , p. 100034
https://dx.doi.org/10.1016/j.crchbi.2022.100034
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