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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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    • GE2R _ Genome Editing, DNA double-strand break Repair and cellular Responses
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Anoud M., Delagoutte Emmanuelle, Helleu Quentin, Brion A., Duvernois-Berthet Evelyne, As M., Marques X., Lamribet K., Senamaud C., Jourdren L., Adrait A., Heinrich S., Toutirais G., Hamlaoui S., Gropplero G. et al., January 2024 — Comparative transcriptomics reveal a novel tardigrade specific DNA binding protein induced in response to ionizing radiation. eLife , ,
https://dx.doi.org/10.7554/eLife.92621.1
Anoud Marwan, Delagoutte Emmanuelle, Helleu Quentin, Brion Alice, Duvernois-Berthet Evelyne, As Marie, Marques Xavier, Lamribet Khadija, Senamaud-Beaufort Catherine, Jourdren Laurent & others, 2024 — Comparative transcriptomics reveal a novel tardigrade-specific DNA-binding protein induced in response to ionizing radiation. Elife vol. 13, , RP92621
Westbrook Alex, Routhier Etienne, Mozziconacci Julien, Koszul Romain & Boulé Jean-Baptiste, November 2023 — Nucleosome positioning in yeast: from prediction to synthetic design. , , Poster
https://mnhn.hal.science/mnhn-04344672
Routhier Ethienne, Joubert Alexandra, Westbrook Alex, Pierre Edgar, Lancrey Astrid, Cariou Marie, Boulé Jean-Baptiste & Mozziconacci Julien, 2023 — In silico design of DNA sequences for in vivo nucleosome positioning. Nucleic Acids Research vol. 52, n° 12,
https://dx.doi.org/10.1093/nar/gkae468
Lancrey Astrid, Joubert Alexandra, Duvernois-Berthet Evelyne, Routhier Etienne, Raj Saurabh, Thierry Agnès, Sigarteu Marta, Ponger Loic, Croquette Vincent, Mozziconacci Julien & Boulé Jean-Baptiste, April 2022 — Nucleosome positioning on large tandem DNA repeats of the ’601’ sequence engineered in Saccharomyces cerevisiae. Journal of Molecular Biology , ,
https://dx.doi.org/10.1016/j.jmb.2022.167497
Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, September 2021 — Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3’ toward 5’, a feature due to a 3’-end binding preference and to structuring of telomeric DNA. Nucleic Acids Research vol. 49, , dir. {Oxford University Press} p. 10735-10746
https://dx.doi.org/10.1093/nar/gkab768
Decombe Sheldon, Loll François, Caccianini Laura, Affannoukoué Kévin, Izeddin Ignacio, Mozziconacci Julien, Escudé Christophe & Lopes Judith, July 2021 — Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability. Epigenetics & Chromatin vol. 14, n° 1, dir. {BioMed Central}
https://dx.doi.org/10.1186/s13072-021-00410-x
Haschka Thomas, Ponger Loic, Escude Christophe & Mozziconacci Julien, June 2021 — MNHN-Tree-Tools: A toolbox for tree inference using multi-scale clustering of a set of sequences. Bioinformatics , , dir. {Oxford University Press (OUP)}
https://dx.doi.org/10.1093/bioinformatics/btab430
Tran Phong Lan Thao, Rieu Martin, Hodeib Samar, Joubert Alexandra, Ouellet Jimmy, Alberti Patrizia, Bugaut Anthony, Allemand Jean-François, Boulé Jean-Baptiste & Croquette Vincent, 2021 — Folding and persistence times of intramolecular G-quadruplexes transiently embedded in a DNA duplex. Nucleic Acids Research , , dir. {Oxford University Press}
https://dx.doi.org/10.1093/nar/gkab306
Lancrey Astrid, Safa Layal, Chatain Jean, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, March 2018 — The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimie vol. 146, , dir. {Elsevier} p. 68-72
https://dx.doi.org/10.1016/j.biochi.2017.11.017
Cacheux Lauriane, Ponger Loïc, Gerbault-Seureau Michèle, Loll François, Gey Delphine, Richard Florence Anne & Escudé Christophe, 2018 — The Targeted Sequencing of Alpha Satellite DNA in Cercopithecus pogonias Provides New Insight Into the Diversity and Dynamics of Centromeric Repeats in Old World Monkeys. Genome Biology and Evolution vol. 10, n° 7, dir. {Society for Molecular Biology and Evolution} p. 1837-1851
https://dx.doi.org/10.1093/gbe/evy109
Charpentier M., Khedher A. H y, Menoret S., Brion A., Lamribet K., Dardillac E., Boix C., Perrouault L., Tesson L., Geny S., de Cian A., Itier J M, Anegon I., Lopez B., Giovannangeli C. et al., 2018 — CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair. Nature Communications vol. 9, n° 1, dir. {Nature Publishing Group}
https://dx.doi.org/10.1038/s41467-018-03475-7
Solé Anna, Delagoutte Emmanuelle, Ciudad Carlos, Noé Véronique & Alberti Patrizia, February 2017 — Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes. Scientific Reports vol. 7, n° 1, dir. {Nature Publishing Group}
https://dx.doi.org/10.1038/srep39898
Berthelot Vivien, Mouta-Cardoso Gildas, Hégarat Nadia, Guillonneau François, François Jean-Christophe, Giovannangeli Carine, Praseuth Danièle & Rusconi Filippo, June 2016 — The human DNA ends proteome uncovers an unexpected entanglement of functional pathways. Nucleic Acids Research vol. 44, n° 10, dir. {Oxford University Press} p. 4721-4733
https://dx.doi.org/10.1093/nar/gkw121
Renaud Jean-Baptiste, Boix Charlotte, Charpentier Marine, deCian Anne, Cochennec Julien, Duvernois-Berthet Evelyne, Perrouault Loïc, Tesson Laurent, Edouard Joanne, Thinard Reynald, Cherifi Yacine, Menoret Séverine, Fontanière Sandra, de Crozé Noémie, Fraichard Alexandre et al., March 2016 — Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.. Cell Reports vol. 14, n° 9, dir. {Elsevier Inc} p. 2263-72
https://dx.doi.org/10.1016/j.celrep.2016.02.018
Safa Layal, Gueddouda Nassima Meriem, Thiébaut Frédéric, Delagoutte Emmanuelle, Petruseva Irina, Lavrik Olga, Mendoza Oscar, Bourdoncle Anne, Alberti Patrizia, Riou Jean-François & Saintomé Carole, 2016 — 5’ to 3’ Unfolding Directionality of DNA Secondary Structures by Replication Protein A. Journal of Biological Chemistry vol. 291, n° 40, dir. {American Society for Biochemistry and Molecular Biology} p. 21246-21256
https://dx.doi.org/10.1074/jbc.M115.709667
Cacheux Lauriane, Ponger Loïc, Gerbault-Seureau Michèle, Richard Florence Anne & Escudé Christophe, 2016 — Diversity and distribution of alpha satellite DNA in the genome of an Old World monkey: Cercopithecus solatus. BMC Genomics vol. 17, , dir. {BioMed Central} p. 916
https://dx.doi.org/10.1186/s12864-016-3246-5
Boulé Jean-Baptiste, Mozziconacci Julien & Lavelle Christophe, January 2015 — The Polymorphisms of the Chromatin Fiber. Journal of Physics: Condensed Matter vol. 27, n° 3, dir. {IOP Publishing}
https://dx.doi.org/10.1088/0953-8984/27/3/033101
Safa Layal, Delagoutte Emmanuelle, Petruseva Irina, Alberti Patrizia, Lavrik Olga, Riou Jean-François & Saintomé Carole, August 2014 — Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability. Biochimie vol. 103, , p. 80-88
https://dx.doi.org/10.1016/j.biochi.2014.04.006
Marlin Fanny, Simon Philippe, Bonneau Stéphanie, Alberti Patrizia, Cordier Céline, Boix Charlotte, Perrouault Loïc, Fossey Aurélie, Saison-Behmoaras Tula, Fontecave Marc & Giovannangeli Carine, November 2012 — Flavin Conjugates for Delivery of Peptide Nucleic Acids. ChemBioChem vol. 13, n° 17, dir. {Wiley-VCH Verlag}
https://dx.doi.org/10.1002/cbic.201200505
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  • Patrizia ALBERTI
  • Charlotte BOIX
  • Jean-Baptiste BOULÉ
  • Alice BRION
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  • Evelyne DUVERNOIS
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