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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Pan Qiaowei, Feron Romain, Yano Ayaka, Guyomard René, Jouanno Elodie, Vigouroux Estelle, Wen Ming, Busnel Jean-Mickaël, Bobe Julien, Concordet Jean-Paul, Parrinello Hugues, Journot Laurent, Klopp Christophe C., Lluch Jérôme, Roques Céline et al., August 2019 — Identification of the master sex determining gene in Northern pike (Esox lucius) reveals restricted sex chromosome differentiation. PLoS Genetics vol. 15, n° 8, dir. {Public Library of Science} e1008013
https://dx.doi.org/10.1371/journal.pgen.1008013
Steed Emily, Faggianelli Nathalie, Roth Stephane, Ramspacher Caroline, Concordet Jean-Paul & Vermot Julien, 2016 — klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis. Nature Communications vol. 7, , dir. {Nature Publishing Group} p. 11646
https://dx.doi.org/10.1038/ncomms11646
Hovhannisyan Yeranuhi, Li Zhenlin, Callon Domitille, Suspène Rodolphe, Batoumeni Vivien, Canette Alexis, Blanc Jocelyne, Hocini Hakim, Lefebvre Cécile, El-Jahrani Nora, Kitsara Maria, L’honoré Aurore, Kordeli Ekaterini, Fornes Paul, Concordet Jean-Paul et al., January 2024 — Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation. Stem Cell Research and Therapy vol. 15, n° 1, p. 10
https://dx.doi.org/10.1186/s13287-023-03619-7
Martin Lorenzo Sandra, Muniz Moreno Maria del Mar, Atas Helin, Pellen Marion, Nalesso Valérie, Raffelsberger Wolfgang, Prevost Geraldine, Lindner Loic, Birling Marie-Christine, Menoret Séverine, Tesson Laurent, Negroni Luc, Concordet Jean-Paul, Anegon Ignacio & Herault Yann, July 2023 — Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders. Frontiers in Neuroscience vol. 17, , p. 1148683
https://dx.doi.org/10.3389/fnins.2023.1148683
Anoud M., Delagoutte Emmanuelle, Helleu Quentin, Brion A., Duvernois-Berthet Evelyne, As M., Marques X., Lamribet K., Senamaud C., Jourdren L., Adrait A., Heinrich S., Toutirais G., Hamlaoui S., Gropplero G. et al., January 2024 — Comparative transcriptomics reveal a novel tardigrade specific DNA binding protein induced in response to ionizing radiation. eLife , ,
https://dx.doi.org/10.7554/eLife.92621.1
Le Berre Gabriel, Hossard Virginie, Riou Jean-Francois & Guieysse-Peugeot Anne-Laure, June 2019 — Repression of TERRA Expression by Subtelomeric DNA Methylation Is Dependent on NRF1 Binding. International Journal of Molecular Sciences vol. 20, n° 11, dir. {MDPI} p. 2791
https://dx.doi.org/10.3390/ijms20112791
Okyar Alper, Piccolo Enza, Ahowesso Constance, Filipski Elisabeth, Hossard Virginie, Guettier Catherine, La Sorda Rosanna, Tinari Nicola, Iacobelli Stefano & Lévi Francis, June 2011 — Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum. PLoS ONE vol. 6, n° 6, dir. {Public Library of Science} e20393
https://dx.doi.org/10.1371/journal.pone.0020393
Ahowesso Constance, Li Xiao-Mei, Zampera Sinisa, Peteri-Brunbäck Brigitta, Dulong Sandrine, Beau Jacques, Hossard Virginie, Filipski Elisabeth, Delaunay Franck, Claustrat Bruno & Lévi Francis, May 2011 — Sex and dosing-time dependencies in irinotecan-induced circadian disruption.. Chronobiology International vol. 28, n° 5, dir. {Taylor \& Francis} p. 458-70
https://dx.doi.org/10.3109/07420528.2011.569043
Le Berre Gabriel, Hossard Virginie, Riou Jean-Francois & Guieysse-Peugeot Anne-Laure, 2020 — AP-TSS: A New Method for the Analysis of RNA Expression from Particular and Challenging Transcription Start Sites. Biomolecules vol. 10, n° 6, dir. {MDPI} p. 827
https://dx.doi.org/10.3390/biom10060827
Hwang In, Mailliet Patrick, Hossard Virginie, Riou Jean-François, Bugaut Anthony & Roger Lauréline, February 2019 — Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA). Molecules vol. 24, n° 3, dir. {MDPI} p. 577
https://dx.doi.org/10.3390/molecules24030577
Geny Sylvain, Pichard Simon, Poterszman Arnaud & Concordet Jean-Paul, 2021 — Gene Tagging with the CRISPR-Cas9 System to Facilitate Macromolecular Complex Purification. Methods in molecular biology (Clifton, N.J.) vol. 2305, , p. 153-174
https://dx.doi.org/10.1007/978-1-0716-1406-8_8
Antoniou Panagiotis, Hardouin Giulia, Martinucci Pierre, Frati Giacomo, Felix Tristan, Chalumeau Anne, Fontana Letizia, Martin Jeanne, Masson Cecile, Brusson Megane, Maule Giulia, Rosello Marion, Giovannangeli Carine, Abramowski Vincent, de Villartay Jean-Pierre et al., November 2022 — Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression. Nature Communications vol. 13, n° 1, p. 6618
https://dx.doi.org/10.1038/s41467-022-34493-1
Pavani Giulia, Fabiano Anna, Laurent Marine, Amor Fatima, Cantelli Erika, Chalumeau Anne, Maule Giulia, Tachtsidi Alexandra, Concordet Jean-Paul, Cereseto Anna, Mavilio Fulvio, Ferrari Giuliana, Miccio Annarita & Amendola Mario, March 2021 — Correction of \beta-thalassemia by CRISPR/Cas9 editing of the \alpha-globin locus in human hematopoietic stem cells. Blood Advances vol. 5, n° 5, dir. {The American Society of Hematology} p. 1137-1153
https://dx.doi.org/10.1182/bloodadvances.2020001996
Babin Loélia, Darchen Alice, Robert Elie, Aid Zakia, Borry Rosalie, Soudais Claire, Piganeau Marion, de Cian Anne, Giovannangeli Carine, Bawa Olivia, Rigaud Charlotte, Scoazec Jean-Yves, Couronné Lucile, Veleanu Layla, Cieslak Agata et al., December 2022 — De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells. Molecular Cancer vol. 21, n° 1, dir. {BioMed Central} p. 65
https://dx.doi.org/10.1186/s12943-022-01520-0
Rosello Marion, Serafini Malo, Mignani Luca, Finazzi Dario, Giovannangeli Carine, Mione Marina C, Concordet Jean-Paul & del Bene Filippo, June 2022 — Disease modeling by efficient genome editing using a near PAM-less base editor in vivo. Nature Communications vol. 13, n° 1, dir. {Nature Publishing Group} p. 3435
https://dx.doi.org/10.1038/s41467-022-31172-z
Mérien Antoine, Tahraoui-Bories Julie, Cailleret Michel, Dupont Jean-Baptiste, Leteur Céline, Polentes Jérôme, Carteron Alexandre, Polvèche Hélène, Concordet Jean-Paul, Pinset Christian, Jarrige Margot, Furling Denis & Martinat Cécile, 2022 — CRISPR gene editing in pluripotent stem cells reveals the function of MBNL proteins during human in vitro myogenesis. Human Molecular Genetics vol. 31, n° 1, dir. {Oxford University Press (OUP)} p. 41-56
https://dx.doi.org/10.1093/hmg/ddab218
Gaillard Anne-Laure, Mohamad Teddy, Quan Feng B, de Cian Anne, Mosimann Christian, Tostivint Hervé & Pézeron Guillaume, January 2023 — Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology vol. 496, , p. 36-51 working paper or preprint
https://dx.doi.org/10.1101/2022.08.09.503396
Anoud Marwan, Delagoutte Emmanuelle, Helleu Quentin, Brion Alice, Duvernois-Berthet Evelyne, As Marie, Marques Xavier, Lamribet Khadija, Senamaud-Beaufort Catherine, Jourdren Laurent & others, 2024 — Comparative transcriptomics reveal a novel tardigrade-specific DNA-binding protein induced in response to ionizing radiation. Elife vol. 13, , RP92621
Pulman Juliette, Botto Catherine, Malki Hugo, Ren Duohao, Oudin Paul, De Cian Anne, As Marie, Izabelle Charlotte, Saubamea Bruno, Forster Valerie & others, 2024 — Direct delivery of Cas9 or base editor protein and guide RNA complex enables genome editing in the retina. Molecular Therapy Nucleic Acids vol. 35, n° 4,
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  • Patrizia ALBERTI
  • Charlotte BOIX
  • Jean-Baptiste BOULÉ
  • Alice BRION
  • Jean-Paul CONCORDET
  • Anne DE CIAN
  • Emmanuelle DELAGOUTTE
  • Evelyne DUVERNOIS
  • Christophe ESCUDÉ
  • Carine GIOVANNANGELI
  • Anne-Laure GUIEYSSE-PEUGEOT
  • Quentin HELLEU
  • Virginie HOSSARD
  • Khadija LAMRIBET
  • Christophe LAVELLE
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