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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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    • GE2R _ Genome Editing, DNA double-strand break Repair and cellular Responses
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Safa Layal, Gueddouda Nassima Meriem, Thiébaut Frédéric, Delagoutte Emmanuelle, Petruseva Irina, Lavrik Olga, Mendoza Oscar, et al. 2016. “5’ to 3’ Unfolding Directionality of DNA Secondary Structures by Replication Protein A”. Journal of Biological Chemistry 291 (January). {American Society for Biochemistry and Molecular Biology}: 21246-56. doi:10.1074/jbc.M115.709667.
https://dx.doi.org/10.1074/jbc.M115.709667
Solé Anna, Delagoutte Emmanuelle, Ciudad Carlos, Noé Véronique, and Alberti Patrizia. 2017. “Polypurine Reverse-Hoogsteen (PPRH) Oligonucleotides Can Form Triplexes With Their Target Sequences Even under Conditions Where They Fold into G-Quadruplexes”. Scientific Reports 7 (February). {Nature Publishing Group}. doi:10.1038/srep39898.
https://dx.doi.org/10.1038/srep39898
Audry Julien, Maestroni Laetitia, Delagoutte Emmanuelle, Gauthier Tiphaine, Nakamura Toru, Gachet Yannick, Saintomé Carole, Geli Vincent, and Coulon Stephane. 2015. “RPA Prevents G-Rich Structure Formation at Lagging- Strand Telomeres to Allow Maintenance of Chromosome Ends”. EMBO Journal 34 (January). {EMBO Press}: 1942-58. doi:10.15252/embj.201490773.
https://dx.doi.org/10.15252/embj.201490773
Rouis Oumayma, Broussard Cedric, Guillonneau Francois, Boulé Jean-Baptiste, and Delagoutte Emmanuelle. 2020. “Identification of Hemicatenane-Specific Binding Proteins by Fractionation of Hela Nuclei Extracts”. Biochemical Journal 477 (January). {Portland Press}: 509-24. doi:10.1042/BCJ20190855.
https://dx.doi.org/10.1042/BCJ20190855
Delagoutte Emmanuelle, and Baldacci Giuseppe. 2011. “5’CAG and 5’CTG Repeats Create Differential Impediment to the Progression of a Minimal Reconstituted T4 Replisome Depending on the Concentration of DNTPs”. Mol Biol Int 2011 (January): 213824. doi:10.4061/2011/213824.
https://dx.doi.org/10.4061/2011/213824
Millet Armêl, Strauss Francois, and Delagoutte Emmanuelle. 2015. “Use of Double-Stranded DNA Mini-Circles to Characterize the Covalent Topoisomerase-DNA Complex”. Scientific Reports 5 (October). {Nature Publishing Group}. doi:10.1038/srep13154.
https://dx.doi.org/10.1038/srep13154
Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia, and Saintomé Carole. 2021. “Multiple HPOT1–TPP1 Cooperatively Unfold Contiguous Telomeric G-Quadruplexes Proceeding from 3’ Toward 5’, a Feature Due to a 3’-End Binding Preference and to Structuring of Telomeric DNA”. Nucleic Acids Research 49 (September). {Oxford University Press}: 10735-46. doi:10.1093/nar/gkab768.
https://dx.doi.org/10.1093/nar/gkab768
Safa Layal, Delagoutte Emmanuelle, Petruseva Irina, Alberti Patrizia, Lavrik Olga, Riou Jean-François, and Saintomé Carole. 2014. “Binding Polarity of RPA to Telomeric Sequences and Influence of G-Quadruplex Stability”. Biochimie 103 (August): 80-88. doi:10.1016/j.biochi.2014.04.006.
https://dx.doi.org/10.1016/j.biochi.2014.04.006
Anoud Marwan, Delagoutte Emmanuelle, Helleu Quentin, Brion Alice, Duvernois-Berthet Evelyne, As Marie, Marques Xavier, et al. 2024. “Comparative Transcriptomics Reveal a Novel Tardigrade-Specific DNA-Binding Protein Induced in Response to Ionizing Radiation”. Elife 13 (January). eLife Sciences Publications Limited: RP92621.
Lancrey Astrid, Safa Layal, Chatain Jean, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia, and Saintomé Carole. 2018. “The Binding Efficiency of RPA to Telomeric G-Strands Folded into Contiguous G-Quadruplexes Is Independent of the Number of G4 Units”. Biochimie 146 (March). {Elsevier}: 68-72. doi:10.1016/j.biochi.2017.11.017.
https://dx.doi.org/10.1016/j.biochi.2017.11.017
Saintomé Carole, and Delagoutte Emmanuelle. 2018. “Probing Hyper-Negatively Supercoiled Mini-Circles With Nucleases and DNA Binding Proteins”. PLoS ONE 13 (August). {Public Library of Science}: e0202138. doi:10.1371/journal.pone.0202138.
https://dx.doi.org/10.1371/journal.pone.0202138
Anoud M., Delagoutte Emmanuelle, Helleu Quentin, Brion A., Duvernois-Berthet Evelyne, As M., Marques X., et al. 2024. “Comparative Transcriptomics Reveal a Novel Tardigrade Specific DNA Binding Protein Induced in Response to Ionizing Radiation”. ELife, January. eLife Sciences Publication. doi:10.7554/eLife.92621.1.
https://dx.doi.org/10.7554/eLife.92621.1
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  • Patrizia ALBERTI
  • Jean-Baptiste BOULÉ
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  • Jean-Paul CONCORDET
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  • Carine GIOVANNANGELI
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  • (-) Emmanuelle DELAGOUTTE

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