Entité de rattachement
Équipe SANTÉ


01 40 79 36 86

CNRS UMR 7196 / INSERM U1154

43, rue Cuvier - Case Postale 26

75231 Paris Cedex 05, France



  • Sharma Richa, Sahoo Sushree, Honda Masayoshi, Granger Sophie, Goodings Charnise, Sanchez Louis, Künstner Axel, Busch Hauke, Beier Fabian, Pruett-Miller Shondra, Valentine Marcus, Fernandez Alfonso, Chang Ti-Cheng, Géli Vincent, Churikov Dmitri et al., février 2022Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue. Blood vol. 139, n° 7, p. 1039-1051
  • Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, septembre 2021Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3’ toward 5’, a feature due to a 3’-end binding preference and to structuring of telomeric DNA. Nucleic Acids Research vol. 49, , dir. {Oxford University Press} p. 10735-10746
  • Chatain Jean, Blond Alain, Phan Anh Tuân, Saintomé Carole & Alberti Patrizia, juillet 2021GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Research , , dir. {Oxford University Press}
  • Ribeiro Jonathan, Dupaigne Pauline, Petrillo Cynthia, Ducrot Cécile, Duquenne Clotilde, Veaute Xavier, Saintomé Carole, Busso Didier, Guerois Raphaël, Martini Emmanuelle & Livera Gabriel, juin 2021The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex. DNA Repair vol. 102, , p. 103097
  • Aklilu Behailu, Peurois François, Saintomé Carole, Culligan Kevin, Kobbe Daniela, Leasure Catherine, Chung Michael, Cattoor Morgan, Lynch Ryan, Sampson Lauren, Fatora John & Shippen Dorothy, août 2020Functional Diversification of Replication Protein A Paralogs and Telomere Length Maintenance in Arabidopsis. Genetics vol. 215, n° 4, p. 989-1002
  • Fernandes Carlos AH, Morea Edna Gicela O, Dos Santos Gabriel A, da Silva Vitor L, Vieira Marina Roveri, Viviescas Maria Alejandra, Chatain Jean, Vadel Aurelie, Saintome Carole, Fontes Marcos Roberto M & others, 2020A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis. Biochimica et Biophysica Acta (BBA)-General Subjects vol. 1864, n° 7, p. 129607
  • Saintomé Carole & Delagoutte Emmanuelle, août 2018Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins. PLoS ONE vol. 13, n° 8, dir. {Public Library of Science} e0202138
  • Lancrey Astrid, Safa Layal, Chatain Jean, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, mars 2018The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimie vol. 146, , dir. {Elsevier} p. 68-72
  • Gerard-Hirne Tom, Thiebaut Frederic, Sachon Emmanuelle, Desert Alexandre, Drujon Thierry, Guerineau Vincent, Michel Benoit Y., Benhida Rachid, Coulon Stephane, Saintome Carole & Guianvarc’h Dominique, 2018Photoactivatable oligonucleotide probes to trap single-stranded DNA binding proteins: Updating the potential of 4-thiothymidine from a comparative study. Biochimie vol. 154, , dir. {Elsevier} p. 164-175
  • Saintomé C., Alberti Patrizia, Guinot N., Lejault P., Chatain J., Mailliet P., Riou Jean-Francois & Bugaut A., 2018Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures. Chemical Communications vol. 54, n° 15, dir. {Royal Society of Chemistry} p. 1897-1900