Entité de rattachement
Équipe GPA


01 40 79 48 32

CNRS UMR 7196 / INSERM U1154

43, rue Cuvier - Case Postale 26

75231 Paris Cedex 05, France


Responsabilités dans l'unité

Responsable PCR (Radioprotection)


  • Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, septembre 2021Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3’ toward 5’, a feature due to a 3’-end binding preference and to structuring of telomeric DNA. Nucleic Acids Research vol. 49, , dir. {Oxford University Press} p. 10735-10746
  • Rouis Oumayma, Broussard Cedric, Guillonneau Francois, Boulé Jean-Baptiste & Delagoutte Emmanuelle, janvier 2020Identification of hemicatenane-specific binding proteins by fractionation of Hela nuclei extracts. Biochemical Journal vol. 477, n° 2, dir. {Portland Press} p. 509-524
  • Saintomé Carole & Delagoutte Emmanuelle, août 2018Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins. PLoS ONE vol. 13, n° 8, dir. {Public Library of Science} e0202138
  • Lancrey Astrid, Safa Layal, Chatain Jean, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, mars 2018The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimie vol. 146, , dir. {Elsevier} p. 68-72
  • Solé Anna, Delagoutte Emmanuelle, Ciudad Carlos, Noé Véronique & Alberti Patrizia, février 2017Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes. Scientific Reports vol. 7, n° 1, dir. {Nature Publishing Group}
  • Safa Layal, Gueddouda Nassima Meriem, Thiébaut Frédéric, Delagoutte Emmanuelle, Petruseva Irina, Lavrik Olga, Mendoza Oscar, Bourdoncle Anne, Alberti Patrizia, Riou Jean-François & Saintomé Carole, 20165’ to 3’ Unfolding Directionality of DNA Secondary Structures by Replication Protein A. Journal of Biological Chemistry vol. 291, n° 40, dir. {American Society for Biochemistry and Molecular Biology} p. 21246-21256
  • Millet Armêl, Strauss Francois & Delagoutte Emmanuelle, octobre 2015Use of double-stranded DNA mini-circles to characterize the covalent topoisomerase-DNA complex. Scientific Reports vol. 5, n° 1, dir. {Nature Publishing Group}
  • Audry Julien, Maestroni Laetitia, Delagoutte Emmanuelle, Gauthier Tiphaine, Nakamura Toru, Gachet Yannick, Saintomé Carole, Geli Vincent & Coulon Stephane, 2015RPA prevents G-rich structure formation at lagging- strand telomeres to allow maintenance of chromosome ends. EMBO Journal vol. 34, , dir. {EMBO Press} p. 1942-1958
  • Safa Layal, Delagoutte Emmanuelle, Petruseva Irina, Alberti Patrizia, Lavrik Olga, Riou Jean-François & Saintomé Carole, août 2014Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability. Biochimie vol. 103, , p. 80-88
  • Delagoutte Emmanuelle & Baldacci Giuseppe, 20115’CAG and 5’CTG Repeats Create Differential Impediment to the Progression of a Minimal Reconstituted T4 Replisome Depending on the Concentration of dNTPs.. Mol Biol Int vol. 2011, , p. 213824