Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
CNRS UMR 7196 / INSERM U1154
43, rue Cuvier - Case Postale 26
75231 Paris Cedex 05, France
Responsabilités dans l'unité
Responsable PCR (Radioprotection)
Publications
2021
Chatain Jean, Hatem Georges, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, septembre 2021 — Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3’ toward 5’, a feature due to a 3’-end binding preference and to structuring of telomeric DNA. Nucleic Acids Researchvol. 49, , dir. {Oxford University Press}p. 10735-10746
Saintomé Carole & Delagoutte Emmanuelle, août 2018 — Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins. PLoS ONEvol. 13, n° 8, dir. {Public Library of Science}e0202138
Lancrey Astrid, Safa Layal, Chatain Jean, Delagoutte Emmanuelle, Riou Jean-François, Alberti Patrizia & Saintomé Carole, mars 2018 — The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units. Biochimievol. 146, , dir. {Elsevier}p. 68-72
Solé Anna, Delagoutte Emmanuelle, Ciudad Carlos, Noé Véronique & Alberti Patrizia, février 2017 — Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes. Scientific Reportsvol. 7, n° 1, dir. {Nature Publishing Group}
Safa Layal, Gueddouda Nassima Meriem, Thiébaut Frédéric, Delagoutte Emmanuelle, Petruseva Irina, Lavrik Olga, Mendoza Oscar, Bourdoncle Anne, Alberti Patrizia, Riou Jean-François & Saintomé Carole, 2016 — 5’ to 3’ Unfolding Directionality of DNA Secondary Structures by Replication Protein A. Journal of Biological Chemistryvol. 291, n° 40, dir. {American Society for Biochemistry and Molecular Biology}p. 21246-21256
Millet Armêl, Strauss Francois & Delagoutte Emmanuelle, octobre 2015 — Use of double-stranded DNA mini-circles to characterize the covalent topoisomerase-DNA complex. Scientific Reportsvol. 5, n° 1, dir. {Nature Publishing Group}
Delagoutte Emmanuelle & Baldacci Giuseppe, 2011 — 5’CAG and 5’CTG Repeats Create Differential Impediment to the Progression of a Minimal Reconstituted T4 Replisome Depending on the Concentration of dNTPs.. Mol Biol Intvol. 2011, , p. 213824