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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Chung L., Onyango D., Guo Z., Jia P., Dai H., Liu S., Zhou M., et al. 2015. “The FEN1 E359K Germline Mutation Disrupts the FEN1-WRN Interaction and FEN1 GEN Activity, Causing Aneuploidy-Associated Cancers”. Oncogene 34 (January): 902-11.
Piazza A., Serero A., Boule J. B., Legoix-Ne P., Lopes J., and Nicolas A. 2012. “Stimulation of Gross Chromosomal Rearrangements by the Human CEB1 and CEB25 Minisatellites in Saccharomyces Cerevisiae Depends on G-Quadruplexes or Cdc13”. Plos Genetics 8 (January): 17.
Lopes J., Piazza A., Bermejo R., Kriegsman B., Colosio A., Teulade-Fichou M. P., Foiani M., and Nicolas A. 2011. “G-Quadruplex-Induced Instability During Leading-Strand Replication”. Embo Journal 30 (January): 4033-46.
Piazza A., Boule J. B., Lopes J., Mingo K., Largy E., Teulade-Fichou M. P., and Nicolas A. 2010. “Genetic Instability Triggered by G-Quadruplex Interacting Phen-DC Compounds in Saccharomyces Cerevisiae”. Nucleic Acids Research 38 (January): 4337-48.
Ribeyre C., Lopes J., Boule J. B., Piazza A., Guedin A., Zakian V. A., Mergny J. L., and Nicolas A. 2009. “The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo”. Plos Genetics 5 (January). {Public Library of Science}: 14. doi:10.1371/journal.pgen.1000475.
https://dx.doi.org/10.1371/journal.pgen.1000475
Pavani Giulia, Fabiano Anna, Laurent Marine, Amor Fatima, Cantelli Erika, Chalumeau Anne, Maule Giulia, et al. 2021. “Correction of \beta-Thalassemia by CRISPR Cas9 Editing of the \alpha-Globin Locus in Human Hematopoietic Stem Cells”. Blood Advances 5 (March). {The American Society of Hematology}: 1137-53. doi:10.1182/bloodadvances.2020001996.
https://dx.doi.org/10.1182/bloodadvances.2020001996
Boisard Julie, Duvernois-Berthet Evelyne, Duval Linda, Schrével Joseph, Guillou Laure, Labat Amandine, Le Panse Sophie, Prensier Gérard, Ponger Loïc, and Florent Isabelle. 2022. “Marine Gregarine Genomes Reveal the Breadth of Apicomplexan Diversity With a Partially Conserved Glideosome Machinery”. BMC Genomics 23 (December). BioMed Central; {BioMed Central}: 485. doi:10.1186/s12864-022-08700-8.
https://dx.doi.org/10.1186/s12864-022-08700-8
Nahle Sarah, Lutet-Toti Camille, Namikawa Yuto, Piet Mh, Brion Alice, Peyroche Sylvie, Suzuki Michio, Marin Frédéric, and Rousseau Marthe. 2024. “Organic Matrices of Calcium Carbonate Biominerals Improve Osteoblastic Mineralization”. Marine Biotechnology 26 (June). Springer Verlag: 539-49. doi:10.1007/s10126-024-10316-w.
https://dx.doi.org/10.1007/s10126-024-10316-w
Le Mouël Jean-Louis, Lopes Fernando, Courtillot Vincent, Gibert Dominique, and Boulé Jean-Baptiste. 2023. “Is the Earth’s Magnetic Field a Constant? A Legacy of Poisson”. Geosciences 13 (July). MDPI: 202. doi:10.3390/geosciences13070202.
https://dx.doi.org/10.3390/geosciences13070202
Marcaggi Paikan. 2015. “Cerebellar Endocannabinoids: Retrograde Signaling from Purkinje Cells”. Cerebellum (London, England) 14 (June): 341-53. doi:10_1007/s12311-014-0629-5.
ISSN
1473-4222
https://dx.doi.org/10_1007/s12311-014-0629-5
Otsu Yo, Marcaggi Paikan, Feltz Anne, Isope Philippe, Kollo Mihaly, Nusser Zoltan, Mathieu Benjamin, et al. 2014. “Activity-Dependent Gating of Calcium Spikes by A-Type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites”. Neuron 84 (October): 137-51. doi:10_1016/j_neuron_2014_08_035.
ISSN
0896-6273
https://dx.doi.org/10_1016/j_neuron_2014_08_035
Chaumont Joseph, Guyon Nicolas, Valera Antoine M, Dugue Guillaume P, Popa Daniela, Marcaggi Paikan, Gautheron Vanessa, et al. 2013. “Clusters of Cerebellar Purkinje Cells Control Their Afferent Climbing Fiber Discharge”. Proceedings of the National Academy of Sciences of the United States of America 110 (October): 16223-28. doi:10_1073/pnas_1302310110.
ISSN
0027-8424
https://dx.doi.org/10_1073/pnas_1302310110
Marcaggi Paikan, Mutoh Hiroki, Dimitrov Dimitar, Beato Marco, and Knopfel Thomas. 2009. “Optical Measurement of MGluR1 Conformational Changes Reveals Fast Activation, Slow Deactivation, and Sensitization”. Proceedings of the National Academy of Sciences of the United States of America 106 (July): 11388-93. doi:10_1073/pnas_0901290106.
ISSN
0027-8424
https://dx.doi.org/10_1073/pnas_0901290106
Marcaggi Paikan, and Attwell David. 2005. “Endocannabinoid Signaling Depends on the Spatial Pattern of Synapse Activation”. Nature Neuroscience 8 (June): 776-81. doi:10_1038/nn1458.
ISSN
1097-6256
https://dx.doi.org/10_1038/nn1458
Marcaggi P, and Coles JA. 2001. “Ammonium in Nervous Tissue: Transport across Cell Membranes, Fluxes from Neurons to Glial Cells, and Role in Signalling”. Progress in Neurobiology 64 (June): 157-83. doi:10_1016/s0301-0082(00)00043-5.
ISSN
0301-0082
https://dx.doi.org/10_1016/s0301-0082(00)00043-5
Marcaggi P, and Coles JA. 2000. “A Cl(-) Cotransporter Selective for NH(4)(+) over K(+) in Glial Cells of Bee Retina”. The Journal of General Physiology 116 (August): 125-42. doi:10_1085/jgp_116_2_125.
ISSN
0022-1295
https://dx.doi.org/10_1085/jgp_116_2_125
Decombe Sheldon, Loll François, Caccianini Laura, Affannoukoué Kévin, Izeddin Ignacio, Mozziconacci Julien, Escudé Christophe, and Lopes Judith. 2021. “Epigenetic Rewriting at Centromeric DNA Repeats Leads to Increased Chromatin Accessibility and Chromosomal Instability”. Epigenetics & Chromatin 14 (July). BioMed Central. doi:10.1186/s13072-021-00410-x.
https://dx.doi.org/10.1186/s13072-021-00410-x
HAL ID
hal-03336457
Ho Shu, Lajaunie Rebecca, Lerat Marion, Le Mickael, Crépel Valérie, Loulier Karine, Livet Jean, Kessler Jean-Pierre, and Marcaggi Païkan. 2021. “A Stable Proportion of Purkinje Cell Inputs from Parallel Fibers Are Silent During Cerebellar Maturation”. Proceedings of the National Academy of Sciences of the United States of America 118 (November). National Academy of Sciences: e2024890118. doi:10.1073/pnas.2024890118.
https://dx.doi.org/10.1073/pnas.2024890118
HAL ID
hal-04981514
Mozziconacci Julien, and Laine Élodie. 2026. “Comment L’IA Apprend le Langage Secret de L’ADN, et Ce Que la Recherche Y gagne”. The Conversation Media Group [•2015-. ]. doi:10.64628/AAK.x45jqwerp.
https://dx.doi.org/10.64628/AAK.x45jqwerp
HAL ID
hal-05735955
Laine Élodie, and Mozziconacci Julien. 2026. “AlphaGenome, une Nouvelle Avancée en Intelligence Artificielle Pour Explorer Les effets Des mutations Génétiques”. The Conversation Media Group [•2015-. ]. doi:10.64628/AAK.vc7uw5w7p.
https://dx.doi.org/10.64628/AAK.vc7uw5w7p
HAL ID
hal-05735945
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