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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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    • GE2R _ Genome Editing, DNA double-strand break Repair and cellular Responses
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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Momose Tsuyoshi R, de Cian Anne, Shiba Kogiku, Inaba Kazuo, Giovannangeli Carine, and Concordet Jean-Paul. 2018. “High Doses of CRISPR Cas9 Ribonucleoprotein Efficiently Induce Gene Knockout With Low Mosaicism in the Hydrozoan Clytia Hemisphaerica through Microhomology-Mediated Deletion”. Scientific Reports 8 (December). {Nature Publishing Group}. doi:10.1038/s41598-018-30188-0.
https://dx.doi.org/10.1038/s41598-018-30188-0
Cannata Fabio, Brunet Erika, Perrouault Loïc, Roig Victoria, Ait-Si-Ali Slimane, Asseline Ulysse, Concordet Jean-Paul, and Giovannangeli Carine. 2008. “Triplex-Forming Oligonucleotide-Orthophenanthroline Conjugates for Efficient Targeted Genome Modification”. Proceedings of the National Academy of Sciences of the United States of America 105 (July). {National Academy of Sciences}: 9576-81. doi:10.1073/pnas.0710433105.
https://dx.doi.org/10.1073/pnas.0710433105
Mannioui Abdelkrim, Vauzanges Quentin, Fini Jean Baptiste, Henriet Esther, Sekizar Somya, Azoyan Loris, Thomas JeanLéon, et al. 2018. “The Xenopus Tadpole: An in Vivo Model to Screen Drugs Favoring Remyelination”. Multiple Sclerosis Journal 24 (July). {SAGE Publications}: 1421-32. doi:10.1177/1352458517721355.
https://dx.doi.org/10.1177/1352458517721355
Hassani Zahra, François Jean-Christophe, Alfama Gladys, Dubois Ghislaine Morvan, Paris Mathilde, Giovannangeli Carine, and Demeneix Barbara A. 2007. “A Hybrid CMV-H1 Construct Improves Efficiency of PEI-Delivered ShRNA in the Mouse Brain”. Nucleic Acids Research 35 (January). {Oxford University Press}: e65. doi:10.1093/nar/gkm152.
https://dx.doi.org/10.1093/nar/gkm152
Hassani Zahra, Lemkine Gregory F, Erbacher Patrick, Palmier Karima, Alfama Gladys, Giovannangeli Carine, Behr Jean-Paul, and Demeneix Barbara A. 2005. “Lipid-Mediated SiRNA Delivery Down-Regulates Exogenous Gene Expression in the Mouse Brain at Picomolar Levels”. The Journal of Gene Medicine 7 (February). {Wiley}: 198-207. doi:10.1002/jgm.659.
https://dx.doi.org/10.1002/jgm.659
Weber Leslie, Frati Giacomo, Felix Tristan, Hardouin Giulia, Casini Antonio, Wollenschlaeger Clara, Meneghini Vasco, et al. 2020. “Editing a \gamma-Globin Repressor Binding Site Restores Fetal Hemoglobin Synthesis and Corrects the Sickle Cell Disease Phenotype”. Science Advances 6 (February). {American Association for the Advancement of Science (AAAS)}: eaay9392. doi:10.1126/sciadv.aay9392.
https://dx.doi.org/10.1126/sciadv.aay9392
Garcin Edwige B, Gon Stéphanie, Sullivan Meghan, Brunette Gregory J, Cian Anne De, Concordet Jean-Paul, Giovannangeli Carine, et al. 2019. “Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells”. PLoS Genetics 15 (January). {Public Library of Science}: e1008355. doi:10.1371/journal.pgen.1008355.
https://dx.doi.org/10.1371/journal.pgen.1008355
Babin Loelia, Piganeau Marion, Renouf Benjamin, Lamribet Khadija, Thirant Cécile, Deriano Ludovic, Mercher Thomas, Giovannangeli Carine, and Brunet Erika. 2018. “Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells”. IScience 5 (January). {Elsevier}: 19-29. doi:10.1016/j.isci.2018.06.007.
https://dx.doi.org/10.1016/j.isci.2018.06.007
Blasimme Alessandro, Anegon Ignacio, Concordet Jean-Paul, deVos John, Dubart-Kupperschmitt Anne, Fellous Marc, Fouchet Pierre, et al. 2015. “Genome Editing and Dialogic Responsibility: ‘What’s in a Name?’”. American Journal of Bioethics 15 (December). {Taylor \& Francis (Routledge)}: 54-57. doi:10.1080/15265161.2015.1103811.
https://dx.doi.org/10.1080/15265161.2015.1103811
Gerard-Hirne Tom, Thiebaut Frederic, Sachon Emmanuelle, Desert Alexandre, Drujon Thierry, Guerineau Vincent, Michel Benoit Y., et al. 2018. “Photoactivatable Oligonucleotide Probes to Trap Single-Stranded DNA Binding Proteins: Updating the Potential of 4-Thiothymidine from a Comparative Study”. Biochimie 154 (January). {Elsevier}: 164-75. doi:10.1016/j.biochi.2018.08.007.
https://dx.doi.org/10.1016/j.biochi.2018.08.007
Geinguenaud Frédéric, Calandrini Vania, Teixeira José, Mayer Claudine, Liquier Jean, Lavelle Christophe, and Arluison Véronique. 2011. “Conformational Transition of DNA Bound to Hfq Probed by Infrared Spectroscopy”. Physical Chemistry Chemical Physics 13 (January). {Royal Society of Chemistry}: 1222-9. doi:10.1039/c0cp01084g.
https://dx.doi.org/10.1039/c0cp01084g
Lavelle Christophe, Berry Hugues, Beslon Guillaume, Ginelli Francisco, Giavitto Jean-Louis, Kapoula Zoi, Le Bivic André, et al. 2008. “From Molecules to Organisms: Towards Multiscale Integrated Models of Biological Systems”. Theoretical Biology Insights 1 (January). {Libertas Academica Ltd}: 13-22. https://hal.inria.fr/inria-00331281.
https://hal.inria.fr/inria-00331281
Lavelle Christophe. 2019. “La Formulation en Cuisine : Entre Chimie et Alchimie ou la Maitrise Des Molécules”. In Les Métamorphoses de L’aliment. https://hal.archives-ouvertes.fr/hal-03009758.
https://hal.archives-ouvertes.fr/hal-03009758
Recouvreux Pierre, Lavelle Christophe, Barbi Maria, Conde e Silva Natalia, Le Cam Eric, Victor Jean-Marc, and Viovy Jean-Louis. 2011. “Linker Histones Incorporation Maintains Chromatin Fiber Plasticity”. Biophysical Journal 100 (June). {Biophysical Society}: 2726-35. doi:10.1016/j.bpj.2011.03.064.
https://dx.doi.org/10.1016/j.bpj.2011.03.064
Lavelle Christophe, Praly Elise, Bensimon David, Le Cam Eric, and Croquette Vincent. 2011. “Nucleosome-Remodelling Machines and Other Molecular Motors Observed at the Single-Molecule Level”. FEBS Journal 278 (October). {Wiley}: 3596-3607. doi:10.1111/j.1742-4658.2011.08280.x.
https://dx.doi.org/10.1111/j.1742-4658.2011.08280.x
Lavelle Christophe. 2019. “Cuisiner/Pâtisser/Avec/le/Chocolat/:/Jeux/de/Textures”. In Les Goûts du Chocolat Dans le Monde. https://hal.archives-ouvertes.fr/hal-03009787.
https://hal.archives-ouvertes.fr/hal-03009787
Dupaigne Pauline, Lavelle Christophe, Justome Anthony, Lafosse Sophie, Mirambeau Gilles, Lipinski Marc, Piétrement Olivier, and Le Cam Eric. 2008. “Rad51 Polymerization Reveals a New Chromatin Remodeling Mechanism”. PLoS ONE 3 (November). {Public Library of Science}: e3643. doi:10.1371/journal.pone.0003643.
https://dx.doi.org/10.1371/journal.pone.0003643
Lavelle Christophe, and Prunell Ariel. 2007. “Chromatin Polymorphism and the Nucleosome Superfamily: A Genealogy”. Cell Cycle 6 (September). {Taylor \\& Francis}: 2113-9. https://hal.archives-ouvertes.fr/hal-00195692.
https://hal.archives-ouvertes.fr/hal-00195692
Busi Florent, Cayrol Bastien, Lavelle Christophe, LeDerout Jacques, PIETREMENT Olivier, Le Cam Eric, Geinguenaud Frédéric, Lacoste Jérôme, Régnier Philippe, and Arluison Véronique. 2014. “Auto-Assembly As a New Regulatory Mechanism of Noncoding RNA”. Cell Cycle 8 (October). {Taylor \\& Francis}: 952-54. doi:10.4161/cc.8.6.7905.
https://dx.doi.org/10.4161/cc.8.6.7905
PIETREMENT Olivier, Arluison Véronique, and Lavelle Christophe. 2020. “RNA Nanostructure Molecular Imaging”. In RNA Spectroscopy, 319-27. doi:10.1007/978-1-0716-0278-2.
https://dx.doi.org/10.1007/978-1-0716-0278-2
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