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Le laboratoire Structure et Instabilité des génomes UMR 7196 / U1154 est une unité mixte de recherche sous la co-tutelle du Muséum national d'Histoire naturelle, du Centre national de la Recherche Scientifique (CNRS), et de l’Institut national de la santé et de la recherche médicale (Inserm).
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UMR 7196 - U1154 - Structure et Instabilité des Génomes
UMR 7196 - U1154

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marquage yH2AX, 53BP1 et merge en tryptique ©L.Roger

GE2R

Genome Editing, DNA Repair and cellular Responses

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Structure du noyau cellulaire avec les nucléoles (vert) et les centromères (rouge)

ARChE

Repeated DNA, Chromatin, Evolution

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HEK293_GFP_tacgene_©alice.brion

TACGENE

TACGENE was created in 2011 within U1154–UMR7196, to facilitate the access of academic laboratories to genome editing techniques.

GPA

Genomics and Physiology of Adaptation

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Conférence

External seminars

Friday 11 PM in Biophysics Library
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©studioestrategia.com

External seminars

The external seminars correspond to the visiting researchers, who come to present their research work to us.

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©studioestrategia.com
Conférence

Internal seminar

monday at 9h30am
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Transformation de l'ADN

Presentation

Structure et Instabilité des Génomes

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©isnar-img.com

Teachings

Many teacher-researchers and professors of UMR 7196 participate in the following courses within the MNHN but also in other institutions.

Ms Anne-...

Theses and HDR

The theses and HDR that took place in the laboratory as well as those to come.

 

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G4_ G quadruplexes

SANTE

Structure of Nucleic Acids, Telomeres and Evolution

Remy Séverine, Tesson Laurent, Ménoret Séverine, Usal Claire, De Cian Anne, Thepenier Virginie, Thinard Reynald, Baron Daniel, Charpentier Marine, Renaud Jean-Baptiste, Buelow Roland, Cost Gregory J., Giovannangeli Carine, Fraichard Alexandre, Concordet Jean-Paul et al., August 2014 — Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases. Genome Research vol. 24, n° 8, dir. {Cold Spring Harbor Laboratory Press} p. 1371-1383
https://dx.doi.org/10.1101/gr.171538.113
Ménoret Séverine, Tesson Laurent, Rémy Severine, Usal Claire, Thépenier Virginie, Thinard Reynald, Ouisse Laure-Hélène, De Cian Anne, Giovannangeli Carine, Concordet Jean-Paul & Anegon Ignacio, August 2014 — Gene targeting in rats using transcription activator-like effector nucleases. Methods vol. 69, n° 1, dir. {Elsevier} p. 102-107
https://dx.doi.org/10.1016/j.ymeth.2014.02.027
Momose Tsuyoshi R, de Cian Anne, Shiba Kogiku, Inaba Kazuo, Giovannangeli Carine & Concordet Jean-Paul, December 2018 — High doses of CRISPR/Cas9 ribonucleoprotein efficiently induce gene knockout with low mosaicism in the hydrozoan Clytia hemisphaerica through microhomology-mediated deletion. Scientific Reports vol. 8, n° 1, dir. {Nature Publishing Group}
https://dx.doi.org/10.1038/s41598-018-30188-0
Cannata Fabio, Brunet Erika, Perrouault Loïc, Roig Victoria, Ait-Si-Ali Slimane, Asseline Ulysse, Concordet Jean-Paul & Giovannangeli Carine, July 2008 — Triplex-forming oligonucleotide-orthophenanthroline conjugates for efficient targeted genome modification.. Proceedings of the National Academy of Sciences of the United States of America vol. 105, n° 28, dir. {National Academy of Sciences} p. 9576-81
https://dx.doi.org/10.1073/pnas.0710433105
Mannioui Abdelkrim, Vauzanges Quentin, Fini Jean Baptiste, Henriet Esther, Sekizar Somya, Azoyan Loris, Thomas JeanLéon, Du Pasquier David, Giovannangeli Carine, Demeneix Barbara A., Lubetzki Catherine & Zalc Bernard, July 2018 — The Xenopus tadpole: an in vivo model to screen drugs favoring remyelination. Multiple Sclerosis Journal vol. 24, n° 11, dir. {SAGE Publications} p. 1421-1432
https://dx.doi.org/10.1177/1352458517721355
Hassani Zahra, François Jean-Christophe, Alfama Gladys, Dubois Ghislaine Morvan, Paris Mathilde, Giovannangeli Carine & Demeneix Barbara A, 2007 — A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain.. Nucleic Acids Research vol. 35, n° 9, dir. {Oxford University Press} e65
https://dx.doi.org/10.1093/nar/gkm152
Hassani Zahra, Lemkine Gregory F, Erbacher Patrick, Palmier Karima, Alfama Gladys, Giovannangeli Carine, Behr Jean-Paul & Demeneix Barbara A, February 2005 — Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels.. The Journal of Gene Medicine vol. 7, n° 2, dir. {Wiley} p. 198-207
https://dx.doi.org/10.1002/jgm.659
Weber Leslie, Frati Giacomo, Felix Tristan, Hardouin Giulia, Casini Antonio, Wollenschlaeger Clara, Meneghini Vasco, Masson Cecile, de Cian Anne, Chalumeau Anne, Mavilio Fulvio, Amendola Mario, Andre-Schmutz Isabelle, Cereseto Anna, El Nemer Wassim et al., February 2020 — Editing a \gamma-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype. Science Advances vol. 6, n° 7, dir. {American Association for the Advancement of Science (AAAS)} eaay9392
https://dx.doi.org/10.1126/sciadv.aay9392
Garcin Edwige B, Gon Stéphanie, Sullivan Meghan, Brunette Gregory J, Cian Anne De, Concordet Jean-Paul, Giovannangeli Carine, Dirks Wilhelm G, Eberth Sonja, Bernstein Kara A, Prakash Rohit, Jasin Maria & Modesti Mauro, 2019 — Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells. PLoS Genetics vol. 15, n° 10, dir. {Public Library of Science} e1008355
https://dx.doi.org/10.1371/journal.pgen.1008355
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